Truelab LRH-100CL / LRH-150CL / LRH-250CL Low-Temperature Biochemical Incubator

Overview

The Truelab LRH Series Low-Temperature Biochemical Incubators are engineered for precision-controlled environmental conditioning in life science laboratories, pharmaceutical QC environments, and clinical research facilities. Designed around a dual-purpose thermal architecture—capable of both refrigerated storage (down to −20 °C) and elevated temperature incubation (up to +65 °C)—these units support a broad spectrum of applications including microbial culture maintenance, serum and reagent stability testing, long-term biobanking of biological samples, and accelerated stability studies per ICH Q1 guidelines. The system employs a high-efficiency hermetic compressor coupled with an optimized R134a refrigeration circuit, ensuring stable low-temperature operation without ozone-depleting substances. Air circulation is managed via a JAKEL centrifugal blower and a laminar-flow baffle duct design, delivering uniform thermal distribution across the chamber—critical for reproducible assay outcomes and regulatory-compliant validation protocols.

Key Features

• Programmable PID temperature control with 0.1 °C resolution and ±0.5 °C uniformity at ambient-to-65 °C range; ±1 °C at −20 °C setpoint.
• Mirror-finish 304 stainless-steel interior with radius-corner construction for seamless cleaning and ISO 14644-compatible particulate control.
• Double-glazed, insulated observation door minimizes thermal load during visual inspection—no internal temperature perturbation observed during 30-second door opening under steady-state conditions.
• Modular airflow system featuring a low-noise, brushless DC circulation fan and asymmetric baffle geometry ensures <±0.8 °C spatial deviation across full chamber volume (verified per ASTM E2799-21).
• Standard 25 mm or optional 50 mm access port (left-side mounted) enables integration with external sensors, probes, or gas supply lines without compromising chamber integrity.
• Embedded microprocessor controller supports up to 99 multi-step programs, each comprising 30 segments with independent ramp/soak parameters—suitable for USP thermal cycling validation and WHO Annex 9 cold chain simulation.
• Compressor protection logic includes phase-loss detection, high-pressure cutoff, and adaptive start-up delay to extend service life beyond 15,000 operational hours.

Sample Compatibility & Compliance

The LRH series accommodates standard microbiological vessels—including Petri dishes, flasks, vials, cryoboxes, and multiwell plates—on three independently height-adjustable 304 stainless-steel shelves. Chamber dimensions allow vertical stacking of ISO-standard 100 mm Petri dishes (max. 12 layers per shelf) or upright placement of 500 mL Erlenmeyer flasks. Units comply with IEC 61010-1:2010 for laboratory equipment safety and meet EN 60335-2-86:2012 requirements for refrigerated incubators. Optional configurations support GLP/GMP audit readiness: RS485 Modbus RTU interface enables connection to LIMS or SCADA systems; USB data logging meets FDA 21 CFR Part 11 electronic record requirements when paired with validated software (sold separately). Humidity control (optional) utilizes a PTC-heated water reservoir and capacitive RH sensor (±3% RH accuracy), suitable for ISO 8573-1 Class 4 moisture-sensitive cultures.

Software & Data Management

All models include a built-in real-time clock and non-volatile memory retaining program settings and alarm history for ≥10,000 events. Optional RS485 or USB interfaces permit direct communication with Windows-based platforms using Truelab’s certified LabLink™ software—enabling automated data export to CSV, PDF report generation with timestamped metadata, and configurable alarm notifications via email or SMS gateway. Audit trail functionality records user login/logout, parameter changes, and alarm acknowledgments with immutable timestamps—fully traceable for FDA or EMA inspection. Firmware updates are delivered via secure HTTPS portal with SHA-256 signature verification.

Applications

• Long-term storage of heat-labile reagents (e.g., enzymes, antibodies, growth factors) at −20 °C per CLSI GP35-A4 recommendations.
• Controlled-temperature incubation of mesophilic bacteria (e.g., E. coli, S. aureus) and fungi (C. albicans) under ISO 7218:2017-compliant conditions.
• Stability testing of pharmaceutical intermediates per ICH Q5C guidelines, including freeze-thaw cycle simulation.
• Environmental stress testing of medical device packaging per ASTM F1980-22 accelerated aging protocols.
• Cell culture pre-conditioning prior to cryopreservation, maintaining viability through precise ramp-down profiles.
• Regulatory-compliant storage of clinical trial biospecimens aligned with ISBER Best Practices 4th Edition.

FAQ

What is the minimum operating temperature for the LRH-150CL model?

The LRH-150CL achieves a stable setpoint of −20 °C under standard laboratory conditions (ambient ≤30 °C, relative humidity ≤70%).
Can the incubator maintain humidity control without modification?

Humidity regulation is an optional feature requiring installation of the integrated water reservoir, PTC heater, and capacitive RH sensor—factory-configured upon order.
Is the unit compliant with FDA 21 CFR Part 11 for electronic records?

Yes—when equipped with RS485 interface and operated with validated LabLink™ software, full Part 11 compliance (audit trail, electronic signatures, record retention) is achievable.
What validation documentation is provided with shipment?

Each unit ships with Factory Acceptance Test (FAT) report, IQ/OQ protocol templates, and calibration certificate traceable to NIST standards.
Are custom chamber dimensions or power configurations available?

Truelab offers OEM engineering services for non-standard volumes (500–1000 L), 3-phase AC380V variants, and explosion-proof configurations—subject to lead-time and MOQ review.