Waters 2707 Autosampler

Overview

The Waters 2707 Autosampler is a precision-engineered, compact sample introduction system designed for integration with high-performance liquid chromatography (HPLC) and liquid chromatography–mass spectrometry (LC-MS) platforms. Based on the proven syringe-driven, low-dead-volume injection architecture, it delivers consistent, accurate, and highly reproducible sample delivery across diverse analytical workflows. Its modular design supports both standard loop-based and needle-wash configurations, enabling robust operation in regulated environments where carryover minimization, injection precision (<0.25% RSD for peak area), and long-term stability are critical. The system operates under full electronic control via Waters Empower™ or MassLynx™ software, ensuring traceable method execution and compliance-ready data handling.

Key Features

• High-precision syringe-based injection mechanism with programmable draw-and-dispense cycles, supporting volumes from 0.1 µL to 100 µL (with optional extended range)
• Integrated needle wash station with dual-solvent capability (aqueous/organic) to reduce cross-contamination and carryover (<0.005% typical for standard peptides)
• Temperature-controlled sample tray (4–40 °C) for thermally sensitive analytes and enhanced stability during unattended runs
• Robust carousel-style vial rack accommodating up to 120 × 2-mL vials or customizable plate formats (96-well, 384-well)
• Modular architecture compatible with Waters Alliance®, ACQUITY UPLC®, and Xevo® LC-MS systems — fully validated for seamless hardware handshake and status reporting
• Refurbishment includes full mechanical recalibration, fluidic path replacement (tubing, seals, rotor seal), firmware update to latest stable release, and IQ/OQ documentation package

Sample Compatibility & Compliance

The Waters 2707 supports aqueous, organic, and mixed-solvent samples without degradation of sealing integrity or plunger performance. It complies with ISO 9001-certified refurbishment protocols and meets baseline requirements for GLP and GMP environments when operated within validated methods. While not inherently 21 CFR Part 11-compliant as standalone hardware, its native integration with Empower 3 (with Audit Trail, Electronic Signatures, and User Access Control enabled) satisfies FDA-regulated data integrity standards. All refurbished units undergo rigorous leak testing, carryover verification (per USP guidance), and injection repeatability assessment per ASTM E260-19 Annex A1.

Software & Data Management

The autosampler communicates bidirectionally with Waters instrument control software (ICS) through standard RS-232 or Ethernet interfaces. Method parameters—including injection volume, wash cycle count, dwell time, and tray position mapping—are stored within the sequence file and preserved across instrument reboots. Raw status logs (including error codes, motor steps, and valve actuation timestamps) are accessible for troubleshooting and root-cause analysis. For laboratories implementing electronic lab notebooks (ELN) or LIMS, the system supports export of audit-trail-enabled run reports in CSV and PDF formats, with metadata embedded per ALCOA+ principles.

Applications

• Pharmaceutical QC/QA: Assay, dissolution, and stability-indicating assays per ICH Q2(R2) guidelines
• Biopharmaceutical characterization: Peptide mapping, mAb subunit analysis, and glycan profiling requiring low-nL precision
• Environmental testing: EPA Method 8330B (PAHs), 8082 (PCBs), and 548 (pesticides) compliant sample introduction
• Clinical research: Therapeutic drug monitoring (TDM) and biomarker quantification in plasma/serum matrices
• Academic core facilities: High-throughput screening support with automated calibration bracketing and internal standard spiking

FAQ

Is this unit eligible for extended warranty or service contracts?

Yes — all refurbished Waters 2707 units include a 12-month parts-and-labor warranty; optional 24- or 36-month comprehensive service plans are available upon request.
Does the refurbishment include validation documentation?

Each unit ships with an IQ/OQ summary report, including mechanical verification, injection precision data, carryover test results, and firmware version log.
Can the 2707 be integrated with non-Waters HPLC systems?

While optimized for Waters platforms, third-party integration is possible via TTL trigger signals and analog voltage output — however, full method synchronization requires custom scripting or middleware.
What consumables are included with the system?

Standard shipment includes one set of rotor seal, syringe assembly, needle, and wash vials; additional kits (e.g., PEEK tubing, septa, vial caps) are available separately.
Is remote diagnostics supported?

Yes — when connected to a local network and configured with Waters Connect™, remote health monitoring and predictive maintenance alerts are enabled.