Yarong RE-5210A & RE-5210AA 10L Automatic Lifting Rotary Evaporator

Overview

The Yarong RE-5210A and RE-5210AA are heavy-duty, 10-liter capacity rotary evaporators engineered for high-efficiency solvent removal, concentration, and recovery under controlled reduced-pressure conditions. Based on the fundamental principle of thin-film evaporation—where a rotating flask generates a uniform, high-surface-area liquid film while immersed in a thermostatically regulated water bath—the system enables rapid, gentle, and reproducible evaporation of heat-sensitive compounds. Designed for sustained operation in demanding environments—including pharmaceutical process development, fine chemical synthesis, natural product isolation, and academic research labs—the RE-5210 series integrates mechanical robustness with precision thermal and rotational control. Both models operate within a vacuum range of −0.01 to −0.095 MPa (≤399.9 Pa absolute), supporting low-boiling-point solvent removal without thermal degradation. The RE-5210AA variant adds an integrated vacuum controller, programmable time settings, and full-color LCD interface for enhanced operational autonomy and data traceability.

Key Features

• Automated vertical lift mechanism with 180 mm stroke range, enabling precise, repeatable positioning of the evaporation flask relative to the water bath—critical for process scalability and operator safety.
• High-efficiency vertical dual-return condenser with large-diameter (75 mm) ground-glass法兰 interface, optimized for rapid vapor condensation and minimal solvent carryover across wide boiling point ranges (e.g., acetone, ethyl acetate, dichloromethane, and higher-boiling solvents up to ~180 °C).
• PID-controlled digital temperature regulation (ambient to 99 °C, ±1 °C stability) with real-time display; RE-5210AA includes programmable ramp-hold profiles and temperature logging capability.
• Variable-speed drive using industrial-grade imported frequency converter, delivering smooth, low-vibration rotation from 0 to 138 rpm with digital speed readout—ensuring consistent film formation and evaporation kinetics.
• One-piece seamless stainless steel water bath with 3000 W heating power, corrosion-resistant construction, and uniform thermal distribution across the full immersion zone.
• Modular valve-integrated feed and discharge system: front-mounted valve-type addition tube and collection flask valve allow continuous solvent feeding and rapid, drip-free collection bottle exchange without breaking vacuum.

Sample Compatibility & Compliance

The RE-5210A/AA accommodates standard 10 L round-bottom flasks (ISO KF-75 or DIN 29842 compatible) and 5 L collection flasks, supporting aqueous, organic, and mixed-phase solutions commonly encountered in API purification, botanical extract concentration, polymer solution processing, and QC sample preparation. All wetted surfaces—including condenser tubing, vapor ducts, and flask interfaces—are constructed from borosilicate glass (Duran®-grade equivalent) and 304 stainless steel, ensuring chemical resistance to acids, bases, and halogenated solvents. While not certified to IEC 61010-1 or UL 61010B out-of-the-box, the system complies with general laboratory safety requirements for Class II equipment and may be validated per internal SOPs aligned with ISO/IEC 17025, USP , or GMP Annex 15 guidelines when used in regulated environments. Vacuum performance meets ASTM E2912–22 criteria for pressure stability during extended evaporation cycles.

Software & Data Management

The RE-5210A operates via hardware-based digital controls with LED displays for temperature and speed. The RE-5210AA upgrades to a full-color TFT LCD touchscreen interface supporting multi-parameter configuration: setpoint temperature, rotation speed, vacuum target, and timer-based auto-shutdown (up to 99 h 59 min). All operating parameters are logged internally with timestamped entries (non-volatile memory, ≥10,000 records), exportable via USB port in CSV format for audit trail generation. The built-in vacuum controller maintains setpoint pressure within ±0.5% of target across variable load conditions—enabling compliance with FDA 21 CFR Part 11 requirements when paired with validated electronic record systems. Optional RS-485 Modbus RTU output allows integration into centralized lab automation platforms (e.g., LabVantage, Thermo Fisher SampleManager).

Applications

• Concentration of thermolabile natural extracts (e.g., curcuminoids, flavonoids, essential oils) without oxidative decomposition.
• Removal of reaction solvents (THF, DMF, DMSO) post-catalytic coupling or peptide synthesis under inert atmosphere (N₂ or Ar purge compatible).
• Recovery and recycling of high-purity solvents in pilot-scale pharmaceutical manufacturing (batch sizes up to 8 L working volume).
• Drying of nanoparticle suspensions and polymer solutions prior to lyophilization or rheological characterization.
• Preparative-scale fractional distillation support when coupled with optional fractional condenser kits and temperature-gradient baths.

FAQ

What is the maximum recommended working volume for the 10 L flask?
For optimal film formation and bumping prevention, the recommended fill level is 40–60% of flask capacity—i.e., 4–6 L for routine operation. Up to 8 L may be processed under low-viscosity, low-foaming conditions with reduced rotation speed (≤60 rpm) and gradual vacuum ramping.
Is the system compatible with corrosive solvents such as HCl-containing mixtures or concentrated HNO₃?
No. While the condenser and flask are borosilicate glass, the vacuum controller, seals, and gaskets are not chemically rated for strong mineral acids. Use only with organic solvents, water, alcohols, and mild aqueous buffers. For acidic applications, specify optional PTFE-coated valves and Viton-free sealing kits.
Can the RE-5210AA be integrated into a GLP-compliant laboratory information management system (LIMS)?
Yes—via its Modbus RTU interface and timestamped internal log files. Full 21 CFR Part 11 compliance requires supplemental validation of user access controls, electronic signature workflows, and audit trail integrity, which must be performed per site-specific IQ/OQ protocols.
What maintenance intervals are recommended for long-term reliability?
Inspect and replace silicone vacuum tubing every 6 months; clean condenser interior quarterly with ethanol or acetone; verify PID calibration annually using NIST-traceable thermometers; lubricate lift mechanism linear guides biannually with food-grade silicone grease.
Does the unit include a chiller connection for condenser cooling?
No—standard configuration uses ambient air or tap-water cooling. A recirculating chiller (e.g., −10 to +20 °C output) can be connected via standard 10 mm quick-connect fittings to the condenser inlet/outlet ports, significantly improving condensation efficiency for low-boiling solvents (e.g., diethyl ether, pentane).