LOGAN C&D 360 Laboratory Coating System
| Brand | LOGAN |
|---|---|
| Origin | USA |
| Model | C&D 360 |
| Coating Method | Dual-Edge Doctor Blade |
| Drive Mode | Manual or CNC-Controlled |
| Blade Adjustment | Motorized Vertical Lift |
| Substrate Handling | Flatbed with Vacuum Hold-Down |
| Thickness Control Range | 25–1,000 µm (adjustable via micrometer and CNC interface) |
| Display | 7-inch TFT Touchscreen with Multi-Language UI (English, Spanish, Chinese, German) |
| Optional Accessories | Integrated Hot-Air Drying Module (40–120 °C), Activated Carbon Odor Adsorption Unit, Exhaust Ventilation with Thermal Management |
Overview
The LOGAN C&D 360 Laboratory Coating System is an engineered precision platform for controlled, reproducible thin-film deposition of viscous pharmaceutical formulations onto flexible substrates. Designed specifically for preclinical and formulation development labs, it employs a dual-edge doctor blade geometry operating under Couette-type shear conditions to achieve laminar, low-turbulence material transfer. Unlike roller-based or slot-die systems, the C&D 360 utilizes static blade-to-substrate clearance control—eliminating mechanical resonance and enabling sub-5 µm thickness repeatability across 100–300 mm wide webs. Its core function is the uniform application of pressure-sensitive adhesives (PSAs), hydrogels, polymer matrices, and solvent-based suspensions used in transdermal patches, medicated plasters, buccal films, and topical delivery membranes. The system operates within ISO 13485-aligned cleanroom-compatible environments and supports full traceability required for GLP-compliant documentation.
Key Features
- Dual-edge doctor blade assembly with independent vertical motorized lift—enabling rapid blade repositioning without manual recalibration
- Vibration-damped cast-iron base frame with precision-ground granite surface plate (flatness ≤ ±1.5 µm over 300 mm)
- Integrated vacuum hold-down system (−60 kPa nominal) for consistent substrate tension and edge registration on release liners, PET, aluminum foil, and nonwovens
- 7-inch capacitive touchscreen HMI with intuitive parameter mapping: coating speed (0.1–100 mm/s), gap setting (0.025–1.0 mm), dwell time, and drying zone temperature (if equipped)
- Multi-language firmware supporting English, Spanish, German, and Simplified Chinese—fully compliant with ICH E6(R3) training documentation standards
- Modular accessory architecture: hot-air drying module (PID-controlled, 40–120 °C), activated carbon filtration for volatile organic compound (VOC) capture, and thermally managed exhaust ducting
Sample Compatibility & Compliance
The C&D 360 accommodates substrates ranging from 50 mm to 300 mm in width and up to 1.2 mm in thickness—including silicone-coated release papers, polyester films, ethylene-vinyl acetate (EVA) sheets, and electrospun nanofiber mats. It supports Newtonian and shear-thinning formulations with viscosities from 100 to 500,000 mPa·s (measured at 25 °C, 10 s⁻¹). All wet-contact components are electropolished 316L stainless steel or PTFE-coated aluminum, meeting USP Class VI biocompatibility requirements. The system is compatible with ASTM D1337 (adhesive shear strength), ISO 2527 (pressure-sensitive tape testing), and FDA 21 CFR Part 11-ready data logging when paired with LOGAN’s optional LMS-Cloud software suite.
Software & Data Management
When configured with the LOGAN LMS-Cloud interface (v4.2+), the C&D 360 records timestamped operational metadata—including blade position, linear velocity, vacuum pressure, ambient temperature/humidity, and user ID—into encrypted SQLite databases with SHA-256 hashing. Audit trails comply with ALCOA+ principles and support automated PDF report generation per batch. Raw parameter sets can be exported as CSV or XML for integration into LIMS platforms (e.g., LabWare, Thermo Fisher SampleManager). Firmware updates are delivered via secure HTTPS OTA protocol with cryptographic signature verification.
Applications
- Transdermal patch development: precise deposition of matrix-type or reservoir-type drug-in-adhesive layers
- Buclizine, fentanyl, or rotigotine formulation screening under variable drying kinetics
- Topical film dosage forms (e.g., oral dissolving films) requiring <50 µm thickness control
- Medical device coatings: antimicrobial silver-polymer blends on wound contact layers
- QC release testing of commercial patch lots using identical process parameters as GMP manufacturing lines
- Stability studies involving accelerated aging of coated substrates under controlled RH/temperature cycles
FAQ
What substrate widths does the C&D 360 support?
Standard operation supports 50–300 mm web widths; custom tooling kits extend capability to 400 mm upon request.
Is the dual-edge blade geometry adjustable in real time during coating?
Yes—the motorized Z-axis lift allows dynamic gap modulation between 0.025 and 1.0 mm with 0.5 µm resolution, logged synchronously with motion data.
Can the system meet FDA 21 CFR Part 11 requirements?
Fully compliant when deployed with LMS-Cloud v4.2+, including electronic signatures, role-based access control, and immutable audit trails.
Does the optional drying module support inert atmosphere processing?
Nitrogen purge compatibility is available as a factory-installed option (N₂ flow rate: 5–20 L/min, O₂ < 0.1% v/v).
What maintenance intervals are recommended for the vacuum system and blade assembly?
Vacuum pump oil replacement every 500 operational hours; blade edge inspection and recalibration recommended after every 50 coating runs or 200 hours—whichever occurs first.
