Non-Invasive Rat Tail Arterial Blood Pressure Measurement System DSWY-1 by SCChengyi
| Brand | SCChengyi |
|---|---|
| Origin | Sichuan, China |
| Manufacturer Type | Authorized Distributor |
| Country of Origin | China |
| Model | DSWY-1 |
| Pricing | Available Upon Request |
| Sensor Included | Yes |
Overview
The SCChengyi DSWY-1 Non-Invasive Rat Tail Arterial Blood Pressure Measurement System is a dedicated physiological monitoring instrument engineered for longitudinal, stress-minimized blood pressure assessment in conscious, restrained Sprague-Dawley, Wistar, or Lewis rats (typically 200–400 g). It operates on the principle of volume-pressure recording (oscillometric method) combined with tail-cuff occlusion and controlled pneumatic inflation/deflation. A calibrated piezoresistive pressure transducer integrated into the tail cuff assembly detects pulsatile arterial wall motion during gradual cuff deflation; systolic, mean, and diastolic pressures are derived algorithmically from the amplitude envelope of oscillometric waveforms. Designed for repeated daily measurements over weeks, the system avoids surgical cannulation, thereby eliminating infection risk, vascular damage, and postoperative recovery confounders—critical for chronic pharmacological, metabolic, or hypertension studies requiring high inter-session reproducibility.
Key Features
- Integrated high-sensitivity piezoresistive pressure sensor with temperature-compensated signal conditioning circuitry for stable baseline drift performance across ambient lab conditions (18–26 °C)
- Automated, programmable inflation/deflation protocol with adjustable cuff pressure range (0–300 mmHg) and ramp rate (5–20 mmHg/s), optimized for rat tail artery compliance
- Dedicated restraint tube with ventilated design and adjustable head fixation to minimize animal movement artifacts without inducing hyperthermia
- Real-time analog output (0–5 V DC) compatible with third-party data acquisition systems (e.g., PowerLab, ADInstruments; Spike2, CED) for synchronized ECG or locomotor activity integration
- Modular hardware architecture supporting firmware updates via USB interface; no proprietary dongles or locked software licenses
- CE-marked electrical safety compliance (EN 61000-6-2, EN 61000-6-4) and RoHS-conformant component sourcing
Sample Compatibility & Compliance
The DSWY-1 is validated for use with male and female rats aged 8–24 weeks and weighing 180–450 g. Tail diameter range: 4.5–7.2 mm. Not intended for mice, hamsters, or non-rodent species due to cuff geometry and pressure algorithm calibration constraints. All measurement protocols adhere to the ARRIVE 2.0 guidelines for reporting animal research and support adherence to NIH Office of Laboratory Animal Welfare (OLAW) standards. Data collection workflows can be structured to meet GLP-compliant documentation requirements—including operator ID logging, session timestamps, and raw waveform export—facilitating audit readiness for preclinical contract research organizations (CROs).
Software & Data Management
The system includes PC-based acquisition software (Windows 10/11, 64-bit) featuring configurable measurement templates, automatic outlier rejection based on pulse amplitude variance (>25% deviation), and batch export in CSV and MATLAB (.mat) formats. Audit trail functionality records all parameter modifications, session start/end times, and user logins—enabling alignment with FDA 21 CFR Part 11 expectations where electronic records are subject to regulatory review. Raw oscillometric waveforms are stored losslessly at ≥1 kHz sampling rate, permitting retrospective re-analysis using custom algorithms. No cloud storage or telemetry transmission is performed; all data reside locally unless explicitly exported by the user.
Applications
- Antihypertensive drug efficacy screening across dose-response curves (e.g., ACE inhibitors, calcium channel blockers)
- Longitudinal monitoring of spontaneous hypertension development in SHR or Dahl salt-sensitive models
- Assessment of autonomic modulation following vagal nerve stimulation or beta-adrenergic challenge
- Validation of telemetry-derived BP trends in parallel cohort studies requiring cost-effective cross-verification
- Metabolic syndrome studies involving diet-induced obesity and insulin resistance, where repeated restraint stress must be standardized and minimized
- Neurovascular coupling investigations integrating BP with laser Doppler flowmetry or fNIRS signals
FAQ
Is the DSWY-1 suitable for unrestrained or home-cage measurements?
No. The system requires brief, standardized restraint (typically 5–8 minutes per session) to ensure consistent tail positioning and thermal stabilization. Unrestrained measurements are not supported.
Does the device provide direct mean arterial pressure (MAP) calculation?
Yes. MAP is computed in real time using the standard oscillometric algorithm (weighted integral of the oscillometric envelope), not estimated from systolic/diastolic interpolation.
Can the pressure sensor be recalibrated in-house?
Yes. The system includes a NIST-traceable calibration routine accessible via service mode; users may verify zero offset and gain using a certified dead-weight tester (recommended annually).
Is ISO 13485 certification available for this instrument?
The DSWY-1 is classified as a research-use-only (RUO) device under IVD Directive 98/79/EC Annex II; it is not manufactured under an ISO 13485 quality management system, as it is not intended for clinical diagnostic application.
What is the typical warm-up time before first measurement?
A 10-minute thermal equilibration period is recommended after system power-on to stabilize sensor offset and ambient air temperature within the restraint module.
