JINTENG Stainless Steel Triple-Filter Assembly with Silicone Stopper

Overview

The JINTENG Stainless Steel Triple-Filter Assembly with Silicone Stopper is a precision-engineered vacuum-driven filtration system designed for high-integrity sample preparation in regulated and research laboratory environments. Based on the principle of gravity-assisted or vacuum-assisted membrane filtration, this assembly enables simultaneous processing of up to three independent samples under identical pressure differentials—ensuring inter-sample comparability and minimizing operator-induced variability. Constructed entirely from ASTM A240 316L stainless steel (except silicone stoppers), the unit complies with material biocompatibility and corrosion resistance requirements essential for pharmaceutical, biotech, and environmental testing workflows. Its modular architecture supports seamless integration into existing lab vacuum networks and accommodates standard 47 mm or 50 mm diameter membrane filters—making it suitable for particulate analysis, microbial enumeration (e.g., membrane filtration for total viable count), endotoxin testing, and clarification of aqueous or mildly organic solutions.

Key Features

• Triple-position stainless steel filter manifold with individually sealable ports and integrated silicone stoppers for rapid, leak-free sample isolation
• 316L stainless steel construction throughout: filter heads, support rods, base plate, and collection funnels—certified per ASTM A240 and passivated per ASTM A967
• Precision-machined deep-hole bores with Ra ≤ 0.4 µm surface finish to eliminate sample retention and facilitate complete liquid drainage
• Aluminum alloy clamping mechanism with calibrated torque retention—ensures consistent sealing force across all filter positions without over-tightening
• Autoclavable at 121°C for 30 minutes (sterilization compatible with ISO 17665-1); silicone stoppers are removable and replaceable for separate dry-heat or flame sterilization
• No dead-volume design: vertical alignment of funnel, filter head, and collection vessel minimizes residual hold-up volume (< 0.2 mL per channel)

Sample Compatibility & Compliance

The assembly accepts all commercially available 47 mm or 50 mm membrane filters—including mixed cellulose ester (MCE), polyethersulfone (PES), nylon, polytetrafluoroethylene (PTFE), and track-etched polycarbonate—enabling method flexibility across diverse analytes (e.g., bacteria, yeast, particulates ≥ 0.22 µm, suspended solids). It conforms to USP Sterility Tests and Bacterial Endotoxins Test requirements when used with certified low-endotoxin membranes and validated protocols. The system supports GLP-compliant documentation through traceable filter lot numbers and standardized vacuum pressure logging. While not an FDA-cleared device, its materials and dimensional tolerances align with ISO 8573-1 (compressed air purity) and ISO 14644-1 (cleanroom compatibility for Class 5–7 environments).

Software & Data Management

This is a manually operated, non-electronic filtration system; no embedded firmware or software is included. However, it is fully compatible with digital vacuum controllers (e.g., KNF N860.3FT.18 or Vacuubrand PC 3001 Vario) that provide real-time pressure monitoring, programmable ramp profiles, and audit-trail-capable data export (CSV/Excel) compliant with FDA 21 CFR Part 11 when paired with validated electronic lab notebooks (ELNs) such as LabArchives or Benchling. Filter usage logs, sterilization cycles, and maintenance records can be maintained in accordance with ISO/IEC 17025:2017 clause 7.9 (handling of equipment records).

Applications

• Microbial recovery and enumeration per ISO 7218, AOAC 977.27, and EPA Method 1603
• Pharmaceutical water system monitoring (PW, WFI) per USP and EU Annex 1
• Suspended solids quantification in environmental water per ISO 11923
• Pre-filtration of HPLC mobile phases and sample extracts to protect analytical columns
• Clarification of cell culture supernatants and fermentation broths prior to downstream chromatography
• Validation of filter integrity via bubble point or diffusion tests (ASTM F838-22)

FAQ

Can this unit be used with aggressive solvents such as acetone or chloroform?
Yes—316L stainless steel offers broad chemical resistance; however, verify compatibility of selected membrane and silicone stopper materials separately.
Is the silicone stopper certified for USP Class VI biocompatibility?
Standard stoppers meet ISO 10993-5 cytotoxicity requirements; Class VI certification is available upon request with specific lot documentation.
What vacuum pressure range is recommended for optimal flow rate and membrane integrity?
Operational range: 20–60 kPa (absolute); maintain ≤ 50 kPa for PTFE membranes and ≤ 40 kPa for low-pressure-rated MCE membranes.
How often should the O-rings and silicone stoppers be replaced?
Replace after 10 autoclave cycles or every 6 months of routine use—whichever occurs first—to ensure seal integrity.
Does the assembly include calibration certificates or material test reports (MTRs)?
MTRs for 316L components are provided with each shipment; calibration is not applicable as no measuring function is integrated.