Leici ZDY-502 Karl Fischer Moisture Analyzer
| Brand | Leici |
|---|---|
| Origin | Shanghai, China |
| Model | ZDY-502 |
| Titration Method | Fully Automatic |
| Type | Volumetric & Coulometric Karl Fischer Moisture Analyzer |
| Moisture Measurement Range | 0.1 mg to 250 mg (equivalent to 0.1 mg – 100% w/w water content) |
| Resolution | 0.1 mg |
| Accuracy | < ±0.75% RSD |
| Minimum Dispensing Increment | 1/20,000 |
| Titration Control Precision | 1/12,000 |
| Polarization Current Accuracy | 1 μA ± 0.2 μA |
| Repeatability | ±0.5% |
| Power Supply | (220 ± 22) V, (50 ± 1) Hz |
| Dimensions (W×D×H) | 340 × 400 × 400 mm |
| Weight | 10 kg |
Overview
The Leici ZDY-502 Karl Fischer Moisture Analyzer is a dual-mode benchtop instrument engineered for precise and reproducible quantitative determination of water content in solid, liquid, and gaseous samples using both volumetric and coulometric Karl Fischer titration principles. Designed in accordance with ISO 8533, ASTM E203, and USP <921> guidelines, the ZDY-502 delivers trace-level moisture quantification across pharmaceutical intermediates, polymers, petrochemicals, food ingredients, and battery electrolytes. Its hybrid architecture enables seamless switching between volumetric titration (for samples containing >100 ppm water) and coulometric titration (for ultra-trace analysis down to sub-ppm levels), ensuring method flexibility without hardware reconfiguration. The system employs a dual-platinum electrode polarization detection system with real-time current monitoring to identify endpoint stability per ICH Q5C and EP 2.5.10 requirements, minimizing false endpoints caused by side reactions or electrode passivation.
Key Features
- Fully automated fluid handling: integrated reagent dosing, waste aspiration, KF solvent mixing, and self-cleaning cycles—eliminating manual intervention and reducing analyst exposure to toxic pyridine-free reagents;
- Dual-mode operation: configurable as volumetric or coulometric analyzer via software selection—no mechanical modification required;
- Integrated anti-spill and anti-backflow protection: patented drip cup overflow sensor and vacuum-controlled waste bottle interface prevent sample contamination and environmental leakage;
- Multi-unit reporting: results exportable in mg, mg/L, % (w/w), % (w/v), and ppm—automatically normalized to sample mass or volume entered pre-analysis;
- GLP-compliant data integrity: 200-method storage capacity with timestamped audit trails, user access levels, and electronic signature support aligned with FDA 21 CFR Part 11 readiness;
- Robust endpoint detection: adaptive polarization current thresholding (1 μA and 50 μA ranges) with ±0.2 μA baseline stability control ensures high repeatability across matrix-varied samples;
- Modular connectivity: native RS-232 and USB interfaces enable direct integration with LIMS, thermal printers, or host PCs running Leici’s validated KF Control Suite v3.2.
Sample Compatibility & Compliance
The ZDY-502 accommodates a broad spectrum of sample types—including hygroscopic powders (e.g., lithium cobalt oxide), viscous oils (e.g., transformer oil), low-volatility solvents (e.g., NMP), and volatile organics (e.g., acetone)—via programmable injection protocols and optional oven coupling (not included). All wet chemistry modules comply with IEC 61010-1 safety standards for laboratory equipment. The instrument’s firmware implements mandatory GLP functions: method versioning, operator ID logging, calibration history retention, and immutable raw data archiving. Validation documentation supports IQ/OQ/PQ execution per GMP Annex 15 and ISO/IEC 17025 accreditation frameworks.
Software & Data Management
Leici KF Control Suite provides a bilingual (English/Chinese) GUI with intuitive workflow navigation, real-time titration curve visualization, and dynamic endpoint prediction algorithms. Data files are stored in encrypted .kfd binary format with embedded metadata (sample ID, analyst, date/time, method parameters, raw current vs. time traces). Export options include CSV, PDF reports (with customizable templates), and direct database push to SQL-based LIMS via ODBC. Audit trail records capture all critical events—including parameter edits, result overrides, and user logins—with SHA-256 hashing for tamper evidence. Software updates are delivered via signed firmware packages verified at boot time.
Applications
- Pharmaceutical QC: residual moisture testing of lyophilized APIs per USP <921>;
- Battery materials: water quantification in cathode precursors (NCM, LFP) where ≤20 ppm H2O is critical for cell longevity;
- Polymer manufacturing: moisture control in PET resin prior to extrusion to prevent hydrolytic degradation;
- Fuel quality assurance: ASTM D6304 compliance for water in diesel and jet fuel;
- Food safety labs: verification of moisture limits in dried dairy powders and cereal flours;
- Electronics: moisture screening of conformal coatings and encapsulants prior to solder reflow.
FAQ
Does the ZDY-502 support both volumetric and coulometric titration in a single instrument?
Yes—the instrument automatically configures its electrochemical cell and dosing system based on the selected method mode within the software interface.
Is the system compliant with 21 CFR Part 11 for electronic records?
It supports core Part 11 requirements including role-based access control, audit trails, and electronic signatures when used with validated KF Control Suite configurations.
Can the ZDY-502 be connected to a laboratory information management system (LIMS)?
Yes—via RS-232 or USB serial emulation, enabling automated result transfer using ASTM E1384 or HL7-compatible protocols.
What maintenance routines are recommended for long-term accuracy?
Daily electrode cleaning with methanol, weekly calibration verification using certified water standards (e.g., Hydranal 1.00 mg/mL), and biannual pump tubing replacement per maintenance logbook.
Is oven heating integrated or optional?
Oven coupling is an external accessory (ZDY-OV100); the base ZDY-502 operates at ambient temperature but accepts heated sample gas streams from compatible ovens.
