Thermo Scientific EXTREVA ASE Accelerated Solvent Extractor and Concentrator
| Brand | Thermo Fisher |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | Authorized Distributor |
| Product Origin | Domestic (China) |
| Model | EXTREVA ASE Accelerated Solvent Extractor and Concentrator |
| Pricing | Available Upon Request |
Overview
The Thermo Scientific EXTREVA ASE Accelerated Solvent Extractor and Concentrator is an integrated, fully automated sample preparation platform engineered for high-efficiency extraction and inline concentration of solid and semi-solid matrices. Leveraging accelerated solvent extraction (ASE®) technology—based on the application of elevated temperature and pressure to enhance solute solubility and mass transfer—the system performs sequential extraction, in-cell cleanup (where applicable), and solvent evaporation in a single, unattended workflow. Unlike conventional off-line workflows requiring manual transfer between extraction and concentration instruments, the EXTREVA ASE eliminates intermediate handling steps, reducing analyst exposure to hazardous solvents and minimizing contamination risk. Designed for compliance-driven laboratories, it supports method development and routine analysis across environmental, food safety, pharmaceutical, and forensic applications where reproducibility, traceability, and regulatory alignment are critical.
Key Features
- Fully integrated extraction–concentration workflow: Performs ASE extraction, optional in-cell filtration or sorbent-based cleanup, and nitrogen-assisted solvent evaporation without manual intervention.
- Parallel processing capability: Simultaneous extraction of up to four samples per run, significantly increasing daily throughput without compromising precision.
- Gas-assisted dynamic extraction mode: Reduces solvent consumption by 5–100 mL per sample versus static ASE protocols, contributing to lower operational costs and reduced chemical waste generation.
- Multi-solvent flexibility: Supports up to six independently programmable solvent channels—including dedicated wash solvents—enabling robust method optimization and cross-method cleaning without manual solvent swaps.
- Precision fluidic control: Integrated mass flow sensors and pressure-regulated delivery ensure consistent solvent delivery rates and extraction kinetics across runs.
- 2D barcode tracking: Integrated scanner reads sample tube barcodes to auto-populate run parameters, link metadata to raw data files, and enforce sample integrity throughout the workflow.
Sample Compatibility & Compliance
The EXTREVA ASE accommodates standard ASE extraction cells (11–100 mL), compatible with a broad range of solid and semi-solid matrices—including soils, sediments, plant tissues, animal feed, polymer composites, and food products. It operates within defined pressure (up to 20 MPa) and temperature (room temperature to 200 °C) ranges appropriate for thermally stable analytes. The system complies with ASTM D7656 (standard test method for determination of polycyclic aromatic hydrocarbons in soil using ASE), EPA Method 3545A, and ISO 14507 for organic contaminant extraction. Data acquisition and audit trail functionality align with GLP and GMP requirements when interfaced with Thermo Scientific Chromeleon CDS, supporting 21 CFR Part 11-compliant electronic records and signatures where configured.
Software & Data Management
Instrument operation, method programming, and real-time monitoring are managed via the intuitive EXTREVA Control Software—compatible with Windows-based workstations. All run logs, including cell identification, solvent sequences, temperature/pressure profiles, and evaporation endpoints, are timestamped and stored locally or exported in CSV/XML format. When connected to Chromeleon CDS, extraction metadata is embedded directly into chromatographic sequence tables, enabling end-to-end traceability from sample intake to analytical detection. Audit trails record user actions, parameter changes, and system events with immutable timestamps, satisfying FDA and EMA data integrity expectations for regulated environments.
Applications
- Environmental analysis: Extraction of PAHs, PCBs, pesticides, and dioxins from soil, sludge, and sediment per EPA and ISO standards.
- Food safety testing: Recovery of mycotoxins, fat-soluble vitamins, pesticide residues, and plasticizers from cereals, dairy powders, and processed meats.
- Pharmaceutical quality control: Isolation of active pharmaceutical ingredients (APIs) and degradation products from solid dosage forms and excipients.
- Forensic toxicology: Efficient recovery of drugs of abuse and metabolites from biological matrices prior to LC-MS/MS analysis.
- Materials science: Leaching studies of additives (e.g., flame retardants, antioxidants) from polymers and composites.
FAQ
Is the EXTREVA ASE compatible with third-party concentrators or only Thermo Scientific evaporators?
The system integrates exclusively with its built-in nitrogen-assisted evaporation module; external concentrators are not supported to maintain method integrity and regulatory compliance.
Can the instrument perform extraction and concentration in separate batches?
Yes—users may configure standalone extraction-only or concentration-only modes for method development or troubleshooting purposes.
What validation documentation is provided with the system?
Factory-verified IQ/OQ documentation is supplied, including pressure calibration certificates, temperature uniformity reports, and solvent delivery accuracy verification data.
Does the system support remote monitoring or integration with LIMS?
Via Chromeleon CDS API and OPC UA connectivity options, the EXTREVA ASE supports scheduled status queries and event-triggered LIMS updates for sample lifecycle synchronization.
How is carryover mitigated between runs?
Automated cell and fluidic path rinsing with designated wash solvents—programmable per method—ensures <0.1% carryover for high-sensitivity applications when validated per ICH Q2(R2) guidelines.
