HOGON MT-V6 Multi-Channel Automatic Potentiometric Titrator
| Brand | HOGON |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | Direct Manufacturer |
| Product Category | Domestic |
| Model | MT-V6 |
| Instrument Type | General-Purpose Potentiometric Titrator |
| Application Scope | Universal |
| pH Range | 0.000–14.000, Resolution: 0.001 pH |
| mV Measurement Range | ±2000.0 mV, Resolution: 0.1 mV |
| mV Accuracy | ±0.1 mV |
| Titration Precision | 1 µL (20 mL burette, standard), 0.5 µL (10 mL burette, optional) |
| Temperature Range | 0–100 °C, Accuracy: ±0.5 °C |
Overview
The HOGON MT-V6 Multi-Channel Automatic Potentiometric Titrator is a modular, high-precision electrochemical analysis platform engineered for rigorous quantitative titrimetric analysis across regulated and research-intensive environments. It operates on the fundamental principle of potentiometric endpoint detection—measuring the potential difference between a reference electrode and an indicator electrode as titrant is incrementally delivered—enabling precise stoichiometric determination in acid-base, redox, precipitation, complexometric, and non-aqueous titrations. Unlike single-channel systems, the MT-V6 integrates up to six independent titration channels within a single chassis, each equipped with dedicated micro-stepper-driven burettes, isolated fluidic pathways, and synchronized electrode signal acquisition. This architecture eliminates cross-contamination risk and supports true parallel analysis—critical for laboratories handling high-throughput QC workflows in pharmaceutical, chemical, food, battery electrolyte, and environmental testing applications. The instrument’s core measurement engine complies with ISO 8655-3 (burette accuracy), ASTM E2087 (potentiometric titration practice), and USP (titrimetric assays), ensuring data integrity aligned with GLP and GMP expectations.
Key Features
- Multi-mode endpoint detection: Simultaneous support for potentiometric (mV/pH), photometric (absorbance at selectable wavelengths), and visual colorimetric titration—enabling method flexibility without hardware reconfiguration.
- True parallel multi-channel operation: Six independently controlled titration stations with individual burette calibration, electrode positioning, and real-time mV/pH monitoring; no shared valves or manifolds.
- High-fidelity fluid handling: Standard 20 mL glass burette with 1 µL dispensing resolution (0.005% of full scale); optional 10 mL burette achieves 0.5 µL resolution; all burettes feature PTFE-coated pistons and integrated air-gap compensation.
- Dual-range electrode interface: Measures -2000.0 to +2000.0 mV with 0.1 mV resolution and 0.001 pH resolution over 0.000–14.000 pH range; auto-ranging analog-to-digital conversion minimizes quantization error.
- Integrated auxiliary automation: Onboard peristaltic pumps for automatic solvent preparation, indicator dosing, sample dissolution, post-titration line flushing, and waste evacuation—reducing manual intervention to <5 minutes per batch.
- Modular expandability: Compatible with HOGON-AS-TR16 robotic autosampler (16-position, temperature-controlled tray) for unattended 24/7 operation; supports optional thermometric and conductometric modules via standardized I/O ports.
Sample Compatibility & Compliance
The MT-V6 accommodates aqueous, non-aqueous (e.g., glacial acetic acid, DMF), and mixed-solvent matrices without modification—validated for use with perchloric acid, tetrabutylammonium hydroxide, silver nitrate, EDTA, and ceric sulfate titrants. Electrode compatibility includes combination pH electrodes, double-junction reference electrodes, platinum redox sensors, silver/silver chloride, and custom ion-selective probes. All firmware and data handling comply with FDA 21 CFR Part 11 requirements: electronic signatures, role-based access control (four-tier user hierarchy), immutable audit trails (timestamped operator ID, parameter changes, method edits, result exports), and cryptographic PDF report generation with embedded digital signatures. Data export protocols include HL7, ASTM E1384, and direct SQL insertion for LIMS/MES integration (e.g., LabWare, Thermo Fisher SampleManager, Siemens Opcenter).
Software & Data Management
The instrument runs HOGON TitrOS v3.2—a Windows-based application supporting method development, validation, and execution. It features ICH Q2(R2)-aligned uncertainty estimation tools, dynamic equivalence point algorithms (1st/2nd derivative, Gran plot, inflection point search), and customizable reporting templates compliant with ISO/IEC 17025 documentation requirements. Raw data (mV vs. volume, pH vs. time, absorbance kinetics) are stored in vendor-neutral HDF5 format with metadata tagging (operator, SOP ID, calibration certificate IDs, ambient temperature/humidity). All reports include embedded calibration logs, reagent lot traceability, and statistical summaries (RSD%, recovery %, spike recovery)—exportable as PDF/A-2u or CSV. Audit trail files are write-once, read-many (WORM) and retained for ≥30 years per configurable retention policy.
Applications
- Pharmaceutical QC: USP/EP-compliant assays for active pharmaceutical ingredients (APIs), including Karl Fischer water content (via coulometric mode), sulfonamide quantification (dead-stop titration), aluminum adjuvant titration in vaccine formulations, and residual catalyst analysis in synthetic intermediates.
- Battery materials: Quantification of HF and acidic impurities in LiPF6 electrolytes; chloride ion detection in lithium cobalt oxide precursors (potentiometric AgNO3 titration); moisture content in solid-state electrolyte powders.
- Food & beverage: Total acidity (TA) in fruit juices (AOAC 942.15), peroxide value in edible oils (AOCS Cd 8-53), sodium chloride in processed meats (Volhard method), and antioxidant capacity (DPPH/ABTS redox titration).
- Environmental testing: COD determination (ISO 6060), cyanide speciation (ASTM D4374), fluoride in drinking water (TISAB-buffered potentiometry), and heavy metal chelation (EDTA back-titration).
- Chemical manufacturing: Acid number (ASTM D974), base number (ASTM D2896), saponification value (ISO 3657), and epoxide content (HCl-acetic anhydride hydrolysis).
FAQ
Does the MT-V6 support Good Manufacturing Practice (GMP) compliance for pharmaceutical production?
Yes. It meets Annex 11 (EU GMP), FDA 21 CFR Part 11, and PIC/S PE 009-16 requirements through validated software, four-level user permissions, full audit trail logging, electronic signatures, and tamper-evident PDF reports.
Can I validate individual titration channels separately?
Yes. Each channel maintains independent calibration records, verification logs, and performance qualification (PQ) data—supporting IQ/OQ/PQ documentation per ASTM E2500.
Is remote monitoring and control possible?
The system supports secure TLS 1.2–encrypted remote desktop access and RESTful API integration for status polling, method upload, and result retrieval via corporate network or VPN.
What electrode maintenance protocols are recommended for long-term stability?
HOGON recommends daily storage in 3 M KCl solution, weekly cleaning with enzymatic detergent for proteinaceous samples, and quarterly reference junction inspection using impedance spectroscopy diagnostics built into TitrOS.
How does the MT-V6 handle viscous or particulate-laden samples?
Optional heated sample holders (up to 80 °C) and ultrasonic-assisted dissolution modules prevent clogging; all fluid paths use 1.6 mm ID PTFE tubing rated for >500 cP viscosity and 50 µm particle tolerance.
