Varian 4000 GC-MS/MS
| Origin | Canada |
|---|---|
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported Instrument |
| Model | 4000 |
| Price Range | USD 42,000 – 70,000 (FOB) |
| Product Category | Chromatography System |
| Operational Age | 4–5 Years |
| Warranty | 6 Months Limited Hardware Warranty |
Overview
The Varian 4000 GC-MS/MS is a dual-stage quadrupole mass spectrometry system coupled with a high-performance gas chromatograph, originally engineered by Varian, Inc. (now part of Agilent Technologies). Designed for targeted quantitative analysis and structural confirmation in complex matrices, this instrument employs electron ionization (EI) and optional chemical ionization (CI) sources, combined with tandem mass spectrometry (MS/MS) scanning modes—including selected reaction monitoring (SRM), multiple reaction monitoring (MRM), and product ion scans. Its architecture supports robust separation of volatile and semi-volatile organic compounds, followed by highly selective detection and quantification at sub-part-per-trillion levels. The system is widely deployed in environmental testing laboratories, food safety QA/QC facilities, forensic toxicology units, and pharmaceutical impurity profiling workflows where regulatory-grade data integrity and method reproducibility are mandatory.
Key Features
- Gas chromatograph equipped with electronic pressure control (EPC), programmable temperature vaporizing (PTV) or split/splitless injectors, and oven temperature range from 4 °C above ambient to 450 °C
- Dual-quadrupole mass spectrometer featuring RF-only collision cell for efficient fragmentation and high transmission efficiency
- Mass range: 10–1000 m/z with unit mass resolution and <1 amu mass accuracy (calibrated)
- Scan speeds up to 10,000 Da/sec, enabling fast chromatographic peak characterization across narrow elution windows
- Integrated tune report generation supporting daily performance verification per ASTM D5845 and EPA Method 8270D requirements
- Refurbished hardware includes fully replaced ion source components, detector assembly, and vacuum system service (turbo-molecular pump and backing pump inspected and validated)
Sample Compatibility & Compliance
The Varian 4000 GC-MS/MS accepts standard 1/4″ or 1/8″ GC columns (e.g., DB-5ms, HP-5MS, Rtx-5Sil MS) and supports derivatized and underivatized analytes including pesticides, PAHs, PCBs, phthalates, flame retardants, and residual solvents. It complies with analytical method standards including US EPA SW-846 Methods 8260, 8270, and 8082; ISO 17025-accredited laboratories routinely validate its use for GLP-compliant studies. All refurbished units undergo full IQ/OQ protocol execution—documented per GAMP5 guidelines—and include traceable calibration certificates aligned with NIST-traceable reference standards.
Software & Data Management
Controlled via Varian MS Workstation v6.9.x or compatible OpenLab CDS (with appropriate licensing bridge), the system supports audit-trail-enabled acquisition, processing, and reporting functions compliant with FDA 21 CFR Part 11 requirements when configured with electronic signatures and role-based access controls. Raw data files (.D format) are fully compatible with third-party quantitation platforms including Chromeleon, MassHunter Quant, and ACD/Labs Spectrus. Each refurbished unit ships with validated software installation media, license transfer documentation (where permitted), and configuration templates for common regulatory methods.
Applications
- Quantitative residue analysis in soil, water, and biota per EU Directive 2002/63/EC and SANTE/11813/2017
- Confirmatory identification of banned substances in doping control laboratories (WADA-accredited protocols)
- Impurity profiling and genotoxic impurity screening in API manufacturing (ICH Q3A/Q3B)
- Volatile organic compound (VOC) speciation in indoor air and workplace exposure assessments (NIOSH Method 2549)
- Forensic toxicology screening for drugs of abuse and metabolites in blood and urine matrices
FAQ
Is this instrument eligible for extended warranty or service contracts?
Yes—SpectraLab Scientific offers optional post-warranty support plans, including annual PM contracts with remote diagnostics, priority spare parts allocation, and on-site engineer dispatch within 48 business hours.
Can the system be upgraded to support newer software versions or additional detectors?
Hardware limitations restrict upgrades beyond MS Workstation v6.9.x; however, compatibility with Agilent’s MassHunter via interface adapter is technically feasible with prior validation.
What documentation accompanies the refurbished unit?
Each shipment includes full refurbishment report, IQ/OQ summary, calibration certificate, EPC and MS tune logs, and original Varian technical manuals in English.
Are consumables and spare parts still available?
Yes—standard GC inlet liners, septa, gold-plated ion source components, and quadrupole rods remain commercially available through authorized Agilent and third-party OEM suppliers.
Does the instrument meet current laboratory accreditation requirements?
When operated within documented specifications and maintained per manufacturer-recommended intervals, the Varian 4000 GC-MS/MS satisfies ISO/IEC 17025 clause 5.5.2 for equipment suitability and ongoing fitness-for-purpose assessment.
