Organomation N-EVAP Series Nitrogen Evaporator

Overview

The Organomation N-EVAP Series Nitrogen Evaporator is an engineered solution for controlled, gentle solvent removal in analytical and preparative laboratories. It operates on the principle of inert gas-assisted surface evaporation: a stream of nitrogen (or compressed air) is directed tangentially across the surface of heated liquid samples, accelerating solvent volatilization while minimizing thermal degradation and oxidation of analytes. Unlike vacuum-based concentrators, the N-EVAP system maintains atmospheric pressure—eliminating foaming, bumping, or cross-contamination risks common in volatile or viscous matrices. Designed specifically for batch processing in regulated environments, it supports reproducible concentration of 50–800 mL sample volumes down to ≤5 mL final volume, with typical solvent recovery exceeding 98% under optimized flow and temperature conditions. Its architecture prioritizes thermal stability, chemical resistance, and operator accessibility—making it suitable for routine use in pharmaceutical QC, clinical toxicology, environmental analysis, and academic research labs.

Key Features

• Modular water bath heating system with precise PID-controlled temperature regulation (0–80 °C), ensuring uniform thermal distribution and minimal sample-to-sample variation.
• Adjustable gas dispersion manifold with individually calibrated needle valves and integrated flow meters (0–10 L/min total range), enabling per-channel flow control and real-time monitoring—critical for method transfer and SOP compliance.
• Rotatable sample rack design allows full frontal access to all positions during operation, reducing handling time and improving ergonomics during multi-step workflows.
• Chemically resistant construction: stainless steel base, anodized aluminum support structures, and optional acid-resistant epoxy coating for extended service life when processing aggressive solvents (e.g., HCl, TFA, or HF-containing extracts).
• Dual configuration options: 12-position and 24-position models accommodate standard test tubes (up to 29 mm OD), centrifuge tubes, conical vials, and culture tubes without adapter modification.
• No dry-block heating option included in this series; water bath ensures consistent, low-gradient heating ideal for thermolabile compounds such as steroids, pesticides, and nucleic acid derivatives.

Sample Compatibility & Compliance

The N-EVAP Series accommodates a broad spectrum of sample containers—including borosilicate glass tubes, polypropylene centrifuge vials, and PTFE-lined screw-cap vials—without requiring custom fixtures. Its open-bath geometry facilitates rapid setup and visual monitoring of evaporation endpoints. From a regulatory standpoint, the instrument meets general laboratory equipment requirements under ISO/IEC 17025:2017 for method validation support. While not intrinsically 21 CFR Part 11-compliant (as it lacks electronic audit trail functionality), its analog controls and mechanical repeatability align with GLP/GMP principles when paired with documented SOPs and manual logbook entries. It is routinely employed in workflows supporting USP , EPA Method 502.2, and ASTM D7089 for residual solvent analysis and extractables profiling.

Software & Data Management

The N-EVAP Series operates via analog controls and does not include embedded software, data logging, or network connectivity. This design choice reflects its role as a dedicated, low-maintenance benchtop tool rather than a digitally integrated platform. Temperature setpoints and gas flow rates are manually adjusted using calibrated dials and analog flow meters. For laboratories requiring traceable process records, integration with external environmental monitoring systems (e.g., Vaisala viewLinc or DeltaTrak) is feasible via optional PT100 probe outputs (available upon request). All units ship with a NIST-traceable calibration certificate for temperature and flow verification at point of installation.

Applications

• Pre-concentration of aqueous and organic extracts prior to GC-MS, LC-MS/MS, or ICP-MS analysis.
• Residual solvent removal in API purification and formulation development per ICH Q3C guidelines.
• Sample cleanup in clinical toxicology (e.g., benzodiazepine screening in urine) and forensic drug testing.
• Environmental sample preparation for PAHs, PCBs, and organochlorine pesticide analysis per EPA SW-846 methods.
• High-throughput lipidomics and metabolomics workflows where parallel processing of 12–24 biological replicates is required.
• Standard addition calibration curve preparation with minimized analyte loss during solvent exchange steps.

FAQ

Can the N-EVAP be used with solvents other than methanol, acetonitrile, or ethyl acetate?
Yes—provided compatibility with wetted materials (stainless steel, anodized aluminum, silicone O-rings) is confirmed. Chlorinated solvents (e.g., chloroform, DCM) are compatible; hydrofluoric acid or hot concentrated sulfuric acid are not.
Is dry-block heating available for higher temperature operation?
No—the N-EVAP Series exclusively uses water bath heating. For applications requiring >80 °C, Organomation offers the Dry-Block N-EVAP variant (separate model line) rated up to 130 °C.
What maintenance is required for long-term reliability?
Routine cleaning of the water bath reservoir and periodic inspection of gas tubing integrity are recommended. Needle valves should be exercised monthly to prevent stiction; no scheduled calibration is required beyond annual NIST-traceable verification.
Does Organomation provide application support for method development?
Yes—application scientists offer free consultation on gas flow optimization, temperature ramping strategies, and container selection for specific analyte classes, supported by published method notes and white papers.
Are replacement parts and service kits available globally?
Yes—all consumables (gas manifolds, sample racks, O-rings) and field-replaceable assemblies are stocked through authorized distributors and backed by a 2-year limited warranty.