Newport NP Series Supercritical Fluid Extraction System
| Brand | Newport |
|---|---|
| Origin | USA |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | NP Series |
| Price | USD $150,000 |
| Max Temperature | 200 °C |
| Number of Channels | 3 |
| Extraction Vessel Volume | 20 L |
| Max Operating Pressure | 68.9 MPa |
| CO₂ Mass Flow Rate | 1 kg/min |
| Extraction Range | Configurable |
Overview
The Newport NP Series Supercritical Fluid Extraction (SFE) System is an engineered platform for precision extraction using supercritical carbon dioxide (scCO₂) as the primary solvent. Based on fundamental thermodynamic principles, scCO₂ exhibits tunable solvation power—modulated via precise control of pressure and temperature—enabling selective isolation of target compounds from complex matrices such as botanicals, polymers, pharmaceuticals, and foodstuffs. This system operates within the critical region of CO₂ (Tc = 31.1 °C, Pc = 7.38 MPa), with full operational range extending to 200 °C and 68.9 MPa (10,000 psi), supporting both laboratory-scale process development and pilot-scale feasibility studies. Its modular architecture integrates three independent fluidic channels—two extraction vessels and one separation vessel—allowing sequential or parallel operation under identical or differentiated process conditions. Designed in accordance with ASME Section VIII Div. 1 for pressure containment and compliant with OSHA 1910.109 and NFPA 70E electrical safety standards, the NP Series meets foundational requirements for GLP-compliant laboratories and pre-GMP process validation environments.
Key Features
- Modular dual-extraction vessel configuration: Standard 10 L and 20 L vessels; optional parallel operation with configurable secondary vessel sizes (1 L, 2 L, 5 L, or 10 L)
- Dual-separation vessel capability: Primary separator (0.75 L) with integrated heat exchanger and Kämmer™ back-pressure regulator; optional secondary separator with automatic reflux control for liquid CO₂ flow modulation
- Coriolis mass flow metering: High-accuracy, temperature-compensated measurement and closed-loop control of CO₂ mass flow up to 1 kg/min
- SFT-patented electro-pneumatic CO₂ flow regulator: Ensures stable, reproducible flow delivery independent of upstream pressure fluctuations
- Compact, mobile cart-based chassis: Fully assembled on a wheeled stainless-steel frame with integrated utility routing (electrical, pneumatic, CO₂ supply)
- ASME-certified pressure components: All vessels, valves, and tubing fabricated from ASTM A240 316L stainless steel with full traceability and coded component identification for serviceability
Sample Compatibility & Compliance
The NP Series accommodates solid, semi-solid, and powdered samples—including plant biomass, spent coffee grounds, polymer films, and nutraceutical powders—within standardized basket inserts compatible with 10 L and 20 L extraction vessels. Separation efficiency is optimized across a wide polarity spectrum via adjustable pressure/temperature gradients and optional co-solvent (entrainer) injection. The system conforms to multiple regulatory frameworks: pressure equipment adheres to ASME BPVC Section VIII Div. 1 and PED 2014/68/EU; electrical design complies with NEC Article 500 (Class I, Division 2) and NFPA 70E arc-flash hazard mitigation guidelines; structural integrity satisfies OSHA 1910.109 for high-pressure chemical processing. While not inherently 21 CFR Part 11–compliant, the SFT-NPX-10 control option provides audit-trail logging, user-level access control, and electronic signature support—enabling alignment with FDA-regulated analytical method development workflows.
Software & Data Management
The optional SFT-NPX-10 control system employs National Instruments cRIO real-time programmable automation controllers (PACs) running LabVIEW Real-Time OS. It delivers deterministic, millisecond-level control over all critical parameters—vessel temperature (±0.5 °C), pressure (±0.1 MPa), and CO₂ mass flow (±0.5% FS)—with synchronized data acquisition at 10 Hz. The 15-inch resistive touchscreen HMI supports multi-tier user authentication (operator, engineer, administrator), parameter lockout, and version-controlled recipe management. Process data—including time-stamped pressure/temperature profiles, flow transients, and alarm history—are logged to internal SSD storage and exportable in CSV or TDMS format. Integration with third-party SCADA systems is supported via OPC UA and Modbus TCP protocols, facilitating centralized monitoring in networked lab environments.
Applications
- Phytochemical isolation: Selective decaffeination, curcuminoid recovery, and terpene fractionation from botanical feedstocks
- Pharmaceutical excipient purification: Residual solvent removal from API intermediates and polymer-based drug carriers
- Food-grade lipid extraction: Omega-3 concentration from fish oil, tocopherol recovery from soy lecithin
- Polymer processing: Supercritical impregnation of antimicrobial agents into medical device substrates
- Environmental sample cleanup: PCB and PAH extraction from soil/sediment prior to GC-MS analysis
- Process scale-up correlation: Direct translation of NP-series operating parameters to industrial-scale SFE systems (e.g., 100–500 L vessels) due to identical control architecture and thermodynamic modeling framework
FAQ
What CO₂ supply infrastructure is required?
Liquid CO₂ must be supplied from certified high-purity (≥99.995%) cylinders or bulk tanks equipped with dip-tube withdrawal. Minimum inlet pressure: 5 MPa; dew point: ≤−40 °C.
Is training provided for system operation and maintenance?
Yes—Newport-certified field engineers deliver on-site installation qualification (IQ), operational qualification (OQ), and comprehensive operator training covering startup/shutdown sequences, preventive maintenance, and emergency response procedures.
Can the system operate continuously for extended durations?
Yes—the NP Series supports unattended 72-hour runs when configured with CO₂ recirculation and automated pressure/temperature ramping; thermal stability is maintained via PID-controlled heating jackets and active cooling loops.
Are replacement parts available with documented traceability?
All ASME-coded pressure components carry permanent laser-etched serial numbers and material test reports (MTRs); spare parts inventory is maintained in North America with standard lead time of 5 business days.
Does the system support GMP documentation packages?
Upon request, Newport supplies full DQ/IQ/OQ documentation templates aligned with ISO 9001:2015 and ASTM E2500-13, including calibration certificates, FAT/SAT records, and risk assessment summaries per ICH Q9.
