Tailin HTY-ADS01 Automated Weight-Based Dilution System

Overview

The Tailin HTY-ADS01 Automated Weight-Based Dilution System is a precision-engineered laboratory instrument designed for reproducible, traceable, and operator-independent dilution of microbiological or environmental samples in compliance with standard methods including ISO 6887-1, ISO 7218, USP <61>/<62>, and Chinese Pharmacopoeia Chapter 1105/1106. Unlike volumetric dilutors relying on fixed-dispense volumes, the HTY-ADS01 employs real-time gravimetric feedback control: it continuously monitors mass change during liquid addition via a high-stability integrated load cell, dynamically terminating dispensing once the target weight-based dilution ratio is achieved. This closed-loop weight-triggered architecture eliminates cumulative volumetric errors from temperature drift, viscosity variation, or meniscus misreading—ensuring consistent dilution accuracy (>98%) across diverse sample matrices (e.g., food homogenates, soil suspensions, clinical swab eluates). Its compact benchtop footprint (38 × 24 × 28 cm) and 13 kg mass support deployment in ISO Class 5–8 cleanrooms, QC labs, and GLP-compliant microbiology testing suites.

Key Features

• Integrated high-resolution load cell (±0.1 g accuracy) with automatic tare compensation and thermal drift compensation algorithms
• Dual independent peristaltic pump modules (Pump A, Pump B, or synchronized A+B operation) using FDA-compliant silicone tubing for chemical resistance and low carryover
• Three dispensing modes: weight-triggered (primary), proportional (fixed % of sample mass), and handheld pipette mode for manual intervention or calibration verification
• 10.1-inch full-color capacitive touchscreen with chemically strengthened tempered glass, supporting glove-compatible operation and multi-language UI (English, Chinese, Spanish)
• Role-based access control with configurable password levels (Operator, Technician, Administrator) enabling audit-ready user accountability
• Built-in balance calibration routine and handheld dispenser volume verification protocol compliant with ISO/IEC 17025 clause 6.4.10
• Rapid-cycle operation: completes single-step serial dilution (e.g., 1:10, 1:100) in under 15 seconds, including bag tare, liquid addition, and stabilization

Sample Compatibility & Compliance

The HTY-ADS01 accommodates standard Stomacher®-compatible homogenization bags (up to 2000 g total loaded mass) and supports viscous, particulate-laden, or foaming samples without clogging due to its positive-displacement peristaltic pumping mechanism. It meets mechanical safety requirements per IEC 61010-1 and electromagnetic compatibility (EMC) per IEC 61326-1. Data integrity aligns with FDA 21 CFR Part 11 principles through electronic signature support, immutable audit trails (user ID, timestamp, action, parameter values), and encrypted local storage of ≥10,000 dilution records. The system is validated for use in pharmaceutical microbiological testing (ICH Q5C, Annex 1), food safety laboratories (ISO/IEC 17025 accredited workflows), and environmental monitoring per EPA Method 1681.

Software & Data Management

Firmware v3.2+ includes embedded SQLite database with export capability to CSV or PDF via USB port. All dilution events are timestamped with millisecond resolution and logged with contextual metadata: operator ID, sample ID, dilution factor, actual achieved mass ratio, pump runtime, ambient temperature/humidity (optional sensor input), and pass/fail status against ±2% tolerance thresholds. Remote diagnostics and firmware updates are supported via secure HTTPS connection (TLS 1.2+). Audit trail reports comply with ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available) for regulatory inspections.

Applications

• Preparation of serial dilutions for aerobic plate counts (APC), coliform enumeration, and pathogen enrichment per ISO 4833-1, ISO 16649-2, and AOAC Official Methods
• Standardized dilution of environmental swabs, rinse waters, and biofilm samples prior to membrane filtration or MPN analysis
• QC release testing of sterile products and non-sterile pharmaceuticals per USP <1111>
• Automated dilution workflows in contract testing laboratories requiring ISO/IEC 17025 traceability and multi-client data segregation
• Research applications requiring high-reproducibility dilution series for dose-response assays or microbial growth kinetics

FAQ

What standards does the HTY-ADS01 comply with for regulatory submissions?

It supports compliance with ISO/IEC 17025, FDA 21 CFR Part 11, EU Annex 11, and pharmacopeial methods including USP <61>, <62>, <1111>, and Ph. Eur. 2.6.12.
Can the system be integrated into a LIMS environment?

Yes—CSV exports and optional RS-232/USB CDC virtual COM port enable bidirectional communication with major LIMS platforms via custom or vendor-provided drivers.
How often must the integrated balance be calibrated?

Daily user-performed verification using certified test weights is recommended; full recalibration by authorized service personnel is required annually or after impact events.
Is tubing replacement a user-serviceable task?

Yes—peristaltic pump heads feature tool-free roller access, and tubing change procedures are guided step-by-step on-screen with visual indicators.
Does the system support multi-step serial dilutions without manual intervention?

No—HTY-ADS01 performs single-step weight-based dilution per cycle; serial dilutions require sequential operator-initiated runs with auto-recall of prior parameters.