HPLC Online Degasser Series HDG-04 / DG-03 / DG-02
| Origin | Shanghai, China |
|---|---|
| Manufacturer Type | Authorized Distributor |
| Product Origin | Domestic (China) |
| Model | HDG-04 / DG-03 / DG-02 |
| Price | USD 1,380 (FOB Shanghai) |
| Channels | 2 (HDG-02), 3 (DG-03), 4 (HDG-04) |
| Degassing Efficiency | ≤1.8 ppm O₂ at 1 mL/min, ≤4.0 ppm O₂ at 5 mL/min (inlet: 8 ppm O₂, 25°C) |
| Vacuum Pressure | −0.085 MPa (absolute) |
| Max Flow per Channel | 10 mL/min |
| Solvent Volume per Channel | 12 mL |
| Dimensions (W×D×H) | 150 × 340 × 180 mm |
Overview
The HPLC Online Degasser Series HDG-04 / DG-03 / DG-02 is an engineered vacuum-based degassing solution designed for integration into high-performance liquid chromatography (HPLC) and ultra-high-performance liquid chromatography (UHPLC) systems. It operates on the principle of membrane-assisted vacuum degassing: solvent streams pass through proprietary hydrophobic microporous PTFE tubing housed within a sealed, continuously evacuated chamber. The pressure differential across the membrane enables dissolved gases—including oxygen, nitrogen, and carbon dioxide—to diffuse selectively from the liquid phase into the vacuum space, where they are removed by a maintenance-free diaphragm vacuum pump. This physical separation mechanism preserves solvent composition integrity, eliminates volatile loss, and prevents chemical alteration—critical for gradient elution, electrochemical detection, fluorescence quantification, and low-UV absorbance measurements. Unlike offline batch degassers or helium sparging, this system delivers continuous, real-time gas removal without solvent exposure to atmosphere, ensuring stable baseline performance and minimizing retention time drift.
Key Features
- Vacuum-driven membrane degassing architecture with integrated diaphragm pump and automatic pressure regulation—no manual intervention required after initial setup.
- Chemically inert PTFE degassing channels resistant to acetonitrile, methanol, THF, aqueous buffers, and aggressive mobile phases (pH 1–12).
- Hermetically sealed fluid path design prevents solvent evaporation, vapor leakage, and operator exposure—compliant with OSHA and CLP hazard communication standards.
- Modular channel configuration: HDG-02 (dual-channel), DG-03 (triple-channel), HDG-04 (quad-channel); all share identical per-channel specifications and mounting footprint.
- Standard 1/16″ stainless steel compression fittings and PEEK tubing interfaces ensure plug-and-play compatibility with Agilent, Waters, Shimadzu, Thermo Fisher, and other major HPLC/UHPLC platforms.
- Low dead volume per channel (12 mL) minimizes solvent waste and equilibration time during method development or gradient switching.
Sample Compatibility & Compliance
The HDG/DG series accommodates all common HPLC solvents and binary/ternary mobile phase mixtures, including water/acetonitrile, water/methanol, and buffered systems containing ammonium acetate or formic acid. It maintains consistent degassing performance across flow rates from 0.1 to 10 mL/min per channel and ambient temperatures from 15°C to 35°C. The device meets ISO 9001 manufacturing controls and conforms to IEC 61010-1 for electrical safety in laboratory equipment. Its sealed operation supports GLP-compliant workflows by eliminating unrecorded solvent handling steps; when paired with audit-trail-enabled CDS software (e.g., Empower, Chromeleon), it contributes to 21 CFR Part 11 readiness through documented system interconnection and operational continuity.
Software & Data Management
While the HDG/DG series operates autonomously without host software dependency, its vacuum status LED and pressure sensor output (0–5 V analog signal) enable integration into centralized lab monitoring systems via optional PLC or DAQ modules. No firmware updates or driver installation are required. All models support remote pump shutdown via dry-contact relay (accessory kit available), facilitating synchronized shutdown during instrument idle states or emergency protocols. Log files generated by connected CDS platforms may include timestamped degasser activation events when interfaced via digital I/O—supporting traceability for QA/QC audits.
Applications
- Baseline stabilization in UV-Vis and photodiode array (PDA) detection, especially below 220 nm where dissolved oxygen induces scattering noise.
- Enabling reproducible electrochemical detection (ECD) by eliminating oxygen-induced background current fluctuations.
- Maintaining fluorescence detector sensitivity by preventing quenching effects from molecular oxygen.
- Supporting robust method transfer between laboratories using identical degassing conditions—critical for regulatory submissions under ICH Q2(R2).
- Reducing bubble formation in low-pressure mixing modules and autosampler needle seats, improving injection precision (RSD < 0.3%).
FAQ
What is the maximum allowable backpressure downstream of the degasser?
The unit is rated for inlet pressures up to 0.6 MPa (6 bar); however, sustained backpressure >0.2 MPa may reduce degassing efficiency due to decreased transmembrane diffusion gradient.
Can the degasser be used with tetrahydrofuran (THF) or chlorinated solvents?
Yes—PTFE membranes and 316 stainless steel wetted parts provide full compatibility with THF, dichloromethane, and chloroform; verify pump oil compatibility if using extended THF exposure.
Is routine maintenance required for the vacuum pump?
No. The oil-free diaphragm pump requires no lubrication or filter replacement and is rated for >10,000 hours of continuous operation.
How does flow rate affect residual oxygen concentration?
Degassing efficiency is inversely proportional to flow rate: at 1 mL/min, residual O₂ is ≤1.8 ppm; at 5 mL/min, ≤4.0 ppm (tested per ASTM D8079-20 using luminescent dissolved oxygen probe).
Does the unit comply with electromagnetic compatibility (EMC) directives?
Yes—certified to EN 61326-1:2013 for laboratory measurement and control equipment, including radiated and conducted emissions testing.
