Supelco Visiprep DL 12-Port Manual Solid Phase Extraction System (Model 57044)

Overview

The Supelco Visiprep DL 12-Port Manual Solid Phase Extraction System (Model 57044) is a precision-engineered vacuum manifold platform designed for reproducible, high-throughput sample cleanup prior to chromatographic or spectroscopic analysis. Operating on the principle of liquid-phase adsorption chromatography, the system enables selective retention and elution of analytes from complex aqueous or partially organic matrices using disposable SPE cartridges. Its DL (Dual-Lock) architecture eliminates cross-contamination between adjacent ports by isolating each sample pathway—preventing carryover even when processing heterogeneous samples in parallel. Unlike conventional vacuum manifolds with shared vacuum channels, the Visiprep DL employs individual PTFE-lined stainless steel solvent delivery needles and patented spiral-flow control valves per port, ensuring independent flow regulation without channel interference. This design supports method robustness across environmental, pharmaceutical, food safety, and clinical toxicology laboratories where regulatory traceability and inter-sample integrity are critical.

Key Features

• Dual-Lock (DL) isolation technology: Physically separates each of the 12 sample pathways to eliminate cross-contamination during sequential or simultaneous processing.
• 12 independent spiral-flow control valves: Precision-machined polypropylene valves with PTFE seals enable fine-tuned, repeatable flow rates (1–6 mL/min range) without manual clamp adjustment or external regulators.
• Chemically inert wetted materials: Borosilicate glass reservoir chamber resists solvent-induced fogging, cracking, or discoloration; all fluid-contact surfaces consist of PTFE, polypropylene, or 316 stainless steel.
• Modular collection platform: Interchangeable polypropylene collection racks accommodate multiple vessel formats—including 1–10 mL volumetric flasks, 10 mm and 16 mm test tubes, autosampler vials, and scintillation vials—without adapter reconfiguration.
• Ergonomic vacuum interface: Integrated vacuum gauge and pressure-regulating valve with 1/4″ OD barbed fitting ensures stable, controllable vacuum levels; compatible with oil-free diaphragm pumps (e.g., Gast DOA-P504-BN or equivalent).
• Tool-free assembly: Lid-mounted valves and pre-installed PTFE transfer lines reduce setup time; removable feet allow stable benchtop placement of the lid during cartridge loading or solvent exchange.

Sample Compatibility & Compliance

The Visiprep DL 57044 accommodates standard 1 mL, 3 mL, and 6 mL SPE cartridges (including Supelco ENVI™, LC-18, and C18 variants) as well as stacked-cartridge configurations using optional adapters (e.g., Supelco 57020-U). It supports low-viscosity aqueous samples up to 6 mL per port; for larger volumes (≥100 mL), optional large-volume sampling tubes (57275 or 57272) integrate directly with the manifold’s inlet ports. All components meet USP Class VI biocompatibility requirements and are certified free of detectable leachables under ICH Q5C guidelines. The system is routinely validated in laboratories adhering to FDA 21 CFR Part 11 (when paired with compliant data loggers), ISO/IEC 17025:2017 (Section 7.2.2, sampling procedures), and EPA Method 500 series for drinking water analysis.

Software & Data Management

As a manually operated platform, the Visiprep DL 57044 does not incorporate embedded firmware or digital controls. However, its mechanical design supports full integration into auditable sample preparation workflows. Each valve position is mechanically indexed and identifiable via engraved port numbering, enabling direct correlation with laboratory notebook entries or LIMS sample IDs. When used with calibrated vacuum pumps equipped with analog/digital pressure output (e.g., Gast DOA-P504-BN with optional transducer), vacuum level logs can be recorded externally for GLP audit trails. Optional buffer bottles (57120-U) provide physical protection against pump contamination and serve as secondary containment for waste solvents—supporting OSHA 29 CFR 1910.1200 hazard communication compliance.

Applications

• Environmental analysis: Cleanup of pesticides, PAHs, and pharmaceutical residues from surface water, wastewater, and soil extracts prior to GC-MS or LC-MS/MS.
• Pharmaceutical QC: Isolation of active pharmaceutical ingredients (APIs) and degradants from tablet dissolution media or plasma ultrafiltrates.
• Food safety testing: Removal of lipids, pigments, and organic acids from milk, juice, and meat homogenates before aflatoxin or mycotoxin quantification.
• Clinical toxicology: Selective enrichment of opioids, benzodiazepines, and stimulants from urine or serum using mixed-mode cation-exchange (MCX) or hydrophilic-lipophilic balance (HLB) sorbents.
• Forensic chemistry: High-recovery extraction of cannabinoids and synthetic cathinones from oral fluid or hair digests under ISO 17025-accredited protocols.

FAQ

Is the Visiprep DL 57044 compatible with non-Supelco SPE cartridges?
Yes—the system accepts any standard 1–6 mL cylindrical SPE cartridge with industry-standard dimensions (e.g., Waters, Phenomenex, Agilent). Adapter kits (e.g., 57020-U) support dual-cartridge stacking or non-standard geometries.
What vacuum pump specifications are recommended?
A dry, oil-free diaphragm pump with ≥20 L/min free-air displacement and ultimate vacuum ≤70 kPa is required. The Gast DOA-P504-BN (25 L/min) is factory-validated; GM-0.33A (20 L/min) serves as an economical alternative.
How is cross-contamination prevented during multi-port operation?
Each port features an isolated PTFE-lined stainless steel needle and dedicated spiral valve—no shared vacuum channels exist between positions. Even if one port stalls or overflows, adjacent channels remain unaffected.
Can the system handle acidic or basic eluents?
Yes—PTFE, borosilicate glass, and polypropylene components resist corrosion from pH 1–13 solutions, including 0.1% phosphoric acid, 0.1 M NaOH, and ammonium acetate buffers.
Is documentation provided for IQ/OQ validation?
Supelco supplies a Certificate of Conformance and dimensional drawings. Users perform operational qualification using standardized test cartridges and gravimetric recovery checks per USP Analytical Instrument Qualification guidelines.