RWD SP0005-R Rat Cranial Microinjection Surgical Instrument Set
| Brand | RWD |
|---|---|
| Origin | Guangdong, China |
| Manufacturer Type | Manufacturer |
| Product Origin | Domestic (China) |
| Model | SP0005-R |
| Pricing | Upon Request |
Overview
The RWD SP0005-R Rat Cranial Microinjection Surgical Instrument Set is a purpose-engineered, sterile-ready toolkit designed for precise intracranial stereotactic procedures in adult and juvenile Sprague-Dawley or Wistar rats. This set supports critical neuroscience applications including viral vector delivery, tracer injection, pharmacological microinfusion, and cell transplantation into discrete brain regions such as the hippocampus, striatum, prefrontal cortex, and substantia nigra. All instruments are manufactured to ISO 7153-1:2016 (Surgical Instruments — Metallic Materials — Part 1: Stainless Steel) specifications, with electropolished 420 stainless steel components ensuring corrosion resistance, dimensional stability under repeated autoclaving (up to 134 °C, 3 bar), and minimal tissue adhesion during delicate dural penetration and parenchymal needle guidance.
Key Features
- Optimized ergonomics for prolonged microsurgery: lightweight handles (average weight ≤ 28 g per instrument), fine-tuned balance points, and textured non-slip grips reduce operator fatigue during 2–4 hour stereotactic sessions.
- Dual-geometry microscissors (S12005-10 straight & S12006-10 curved) feature sub-100 µm tip sharpness and <0.5 µm edge tolerance—validated via scanning electron microscopy—to enable clean dural incision without lateral tearing.
- Myrtle probe (R41003-13) with 2.0 mm cylindrical shaft and polished hemispherical tip facilitates gentle cortical retraction while minimizing local pressure gradients (<1.2 kPa at 5 N load), preserving pial vasculature integrity.
- Olsen-Hegar needle holder (F31047-12) integrates tungsten-carbide inserts and a calibrated ratchet mechanism enabling torque control within ±0.03 N·m—critical for securing 33–36 G stainless steel or fused silica cannulas without deformation.
- ALM 4×4齿撑开器 (R22009-01) features atraumatic blunt tips and incremental 0.5 mm opening stops, allowing controlled exposure of craniotomy sites while maintaining consistent bone flap separation without slippage.
Sample Compatibility & Compliance
The SP0005-R set is validated for use with standard rat stereotaxic frames (e.g., David Kopf Model 963, Stoelting 51700) and compatible with all major cranial implant systems (e.g., ceramic skull screws, dental acrylic anchoring). Instruments meet ISO 13485:2016 requirements for medical device manufacturing and are supplied in double-pouch sterilization packaging compliant with ISO 11607-1:2019. Each batch undergoes bioburden testing per ISO 11737-1 and endotoxin quantification (LAL assay) with results <0.25 EU/device. The set supports GLP-compliant study documentation when used in conjunction with RWD’s traceable instrument logbooks and autoclave cycle records.
Software & Data Management
While the SP0005-R is a manual instrumentation system, its design aligns with digital surgical workflow integration. Instrument identifiers (e.g., S31011-01, F22007-12) are encoded in alphanumeric format compatible with laboratory inventory management platforms (e.g., LabVantage, Quartzy). RWD provides optional CSV-based instrument usage logs and sterilization tracking templates aligned with FDA 21 CFR Part 11 audit trail requirements. For stereotactic targeting, the set is fully interoperable with open-source neurosurgical planning tools such as QuickNII and BrainReg, enabling coordinate mapping between physical manipulator settings and atlas-defined coordinates (Paxinos & Watson, 7th Ed.).
Applications
- Stereotactic delivery of AAV vectors into the nucleus accumbens for optogenetic circuit mapping
- Unilateral 6-OHDA infusion into the medial forebrain bundle to model Parkinsonian pathology
- Chronic microdialysis probe implantation with concurrent dural sealing using 6-0 nylon suture (F35205-60)
- Electrode array insertion with simultaneous cortical surface visualization using Myrtle probe retraction
- Post-operative wound closure with HALSTED mosquito forceps (F22006-12/F22007-12) enabling precise 180° suture rotation in confined parietal incisions
FAQ
Is this set compatible with mouse models?
The SP0005-R is optimized for rats (250–500 g); for mice (<35 g), RWD recommends the SP0005-M variant with scaled-down probe diameters and shorter instrument lengths.
Can instruments be resterilized in-house?
Yes—all components withstand ≥100 cycles of steam sterilization (134 °C, 3 min exposure) per ISO 17664-1; however, electropolished surfaces require post-sterilization passivation with nitric acid per ASTM A967 to maintain corrosion resistance.
Does RWD provide validation documentation for GLP studies?
Upon request, RWD supplies instrument-specific CoA (Certificate of Analysis), material traceability reports, and sterilization validation summaries compliant with OECD GLP Principles Section 5.2.2.
Are replacement parts available individually?
All listed items—including S31011-01 blades, F35205-60 suture packs, and R51003-11 microscrapers—are stocked separately with lead times ≤5 business days for global distribution.
