METTLER TOLEDO XPE Micro Analytical Balance
| Brand | METTLER TOLEDO |
|---|---|
| Origin | Switzerland |
| Model | XPE Micro Analytical Balance |
| Maximum Capacity | 100 g |
| Readability | 0.001 mg (1 µg) |
| Minimum Weight (USP <41>) | 1.4 mg (typical) |
| Repeatability | ≤ ±0.001 g (≤ ±1 mg) |
| Internal Calibration | Automatic, motorized |
| Weighing Pan | SmartGrid™ grid design with ErgoClip™ sample handling accessories |
Overview
The METTLER TOLEDO XPE Micro Analytical Balance is a high-precision weighing instrument engineered for trace-level mass determination in regulated laboratory environments. Utilizing electromagnetic force compensation (EMFC) technology, the XPE series delivers exceptional stability and resolution down to 1 µg (0.001 mg) across multiple models—ranging from 22 g to 100 g maximum capacity. Designed specifically for applications demanding compliance with pharmacopeial standards—including USP , , and EP 2.1.6—the balance integrates real-time environmental monitoring, automatic internal adjustment, and hardware-based drift compensation to ensure consistent metrological performance under dynamic lab conditions. Its robust monolithic sensor architecture minimizes mechanical hysteresis and thermal drift, while the hermetically sealed transducer protects against particulate contamination and humidity-induced signal noise.
Key Features
- SmartGrid™ Weighing Pan: A precision-machined stainless-steel grid structure that reduces air turbulence and accelerates stabilization time by up to 30% compared to conventional solid pans—critical for low-mass, high-sensitivity measurements.
- ErgoClip™ Sample Handling System: Modular, tool-free clamping fixtures enabling direct dosing into target vessels (e.g., volumetric flasks, HPLC vials, or crucibles) without intermediate transfer—reducing static charge accumulation and cross-contamination risk.
- LevelControl™ Integrated Leveling System: Built-in dual-axis inclinometer with visual LED guidance and automatic tilt compensation; eliminates manual bubble-level dependency and ensures gravitational vector alignment within ±0.2°.
- MinWeigh™ Function: Real-time calculation of minimum weight per USP based on current repeatability and readability—displayed dynamically during operation and logged with audit trail metadata.
- AutoCal™ Motorized Internal Calibration: Temperature- and time-triggered recalibration using certified internal weights; supports scheduled verification intervals aligned with ISO/IEC 17025 and GLP documentation requirements.
- StaticDetect™ Technology: Integrated ionization monitoring that identifies electrostatic interference in real time and prompts user-initiated discharge protocols—essential for accurate weighing of powders, polymers, and low-conductivity solvents.
Sample Compatibility & Compliance
The XPE platform accommodates a broad spectrum of sample types—including hygroscopic solids, volatile organics, fine pharmaceutical powders, catalyst nanoparticles, and reference standards—without compromising repeatability or linearity. All models comply with international regulatory frameworks: full traceability to SI units via PTB/NIST-traceable calibration certificates; conformity with OIML R76-1 (Class I), ISO 9001, and ISO/IEC 17025 accreditation guidelines; and built-in support for FDA 21 CFR Part 11-compliant electronic records (user authentication, audit trail, electronic signatures). Optional GxP validation packages include IQ/OQ/PQ protocols, risk assessments (ICH Q9), and raw data export in .csv/.xlsx formats with embedded metadata timestamps.
Software & Data Management
XPE balances operate natively with METTLER TOLEDO’s LabX® software—a centralized, server-based platform enabling remote configuration, method deployment, and automated report generation. LabX enforces role-based access control (RBAC), provides full electronic audit trails compliant with ALCOA+ principles, and supports seamless integration with LIMS, ERP, and ELN systems via OPC UA or RESTful APIs. All weighing events—including tare, gross, net, and statistical summaries—are timestamped, digitally signed, and archived with immutable hash verification. Optional OneClick™ reporting generates PDF/Excel reports pre-formatted to meet ISO 17025 clause 7.8 and USP analytical instrument qualification templates.
Applications
- Quantitative preparation of reference standards and certified reference materials (CRMs) in metrology labs
- Weighing of active pharmaceutical ingredients (APIs) during formulation development and batch release testing
- Residue-on-ignition (ROI) and loss-on-drying (LOD) determinations per USP
- Micro-dosing of catalysts and nanomaterials in R&D synthesis workflows
- Calibration of pipettes and volumetric glassware per ISO 8655-6
<liGravimetric analysis for ICP-MS calibration standards and elemental impurity testing (ICH Q3D)
FAQ
What is the smallest sample mass reliably measurable on the XPE series?
The minimum weight is dynamically calculated per USP and typically ranges from 1.4 mg to 2.4 mg depending on model and environmental conditions—displayed in real time via MinWeigh™.
Does the XPE support GLP/GMP audit requirements?
Yes: full 21 CFR Part 11 compliance is enabled via LabX software, including electronic signatures, audit trail review tools, and secure user management with password policies and session timeouts.
How frequently must internal calibration be performed?
AutoCal™ triggers automatically at user-defined intervals (e.g., every 2 hours) or upon temperature change >1.5 °C—configurable to align with internal SOPs and ISO/IEC 17025 clause 6.5.2.
Can the XPE interface directly with a LIMS system?
Yes: native OPC UA connectivity and configurable ASCII/CSV output enable bidirectional data exchange with major LIMS platforms without middleware.
Is the SmartGrid pan compatible with corrosive or abrasive samples?
The SmartGrid pan is constructed from 316L stainless steel with electropolished surface finish—resistant to common laboratory acids, bases, and solvents per ASTM B117 salt-spray testing (≥96 h).
