SSI BLS CLASS High-Pressure Binary Gradient Constant Flow Pump
| Brand | SSI |
|---|---|
| Origin | Imported |
| Model | BLS CLASS |
| Flow Rate | 0.000–10.00 mL/min (up to 6,000 psi) |
| Pressure Rating | 6,000 psi (stainless steel/PEEK fluid path), 5,000 psi (PEEK-only configuration) |
| Pulsation | ≤2% at 1 mL/min and 1,000 psi (with pulse dampener) |
| Flow Accuracy | <±2% of full scale (≥0.20 mL/min, 20% IPA/water, 1,000 psi) |
| Flow Precision | ≤0.2% RSD |
| Fluid Path Materials | Stainless steel, PEEK, optional titanium |
| Dimensions | 22.9 cm H × 25.4 cm W × 43.2 cm D |
| Weight | 13.6 kg |
| Power Input | 100–240 VAC ±10%, 50–60 Hz |
| Control Interfaces | RS-232, Micro-USB, analog (0–10 V / 4–20 mA), discrete Run/Stop |
Overview
The SSI BLS CLASS High-Pressure Binary Gradient Constant Flow Pump is an engineered solution for precise, reproducible solvent delivery in analytical and preparative liquid chromatography systems. Built upon dual independent positive-displacement piston pump architecture, it operates on the principle of reciprocating displacement with electronically synchronized refill cycles and cam-profiled belt-driven actuation—ensuring minimal flow perturbation and high-pressure stability. Each pump head integrates a shaped cam mechanism and fast electronic refill control, enabling consistent volumetric output across its operational range. The system supports true binary gradient formation via real-time, independently programmable flow rate modulation of two solvents, eliminating reliance on post-column mixing or external gradient controllers. Designed for integration into HPLC, UHPLC, SFC, and method development workflows, the BLS CLASS delivers metrological-grade flow consistency under sustained high backpressure—critical for retention time reproducibility, peak shape fidelity, and column longevity.
Key Features
- Dual single-head piston pumps housed in a rigid, vibration-damped enclosure with integrated thermal management
- Belt-driven cam mechanism with electronic fast-refill cycle synchronization for low-pulsation performance (≤2% pulsation at 1 mL/min, 1,000 psi, with optional pulse dampeners)
- Stainless steel and PEEK fluidic pathways; optional titanium wetted components for aggressive solvents or high-corrosion applications
- Integrated pressure transducer with real-time monitoring and over-pressure shutdown logic (6,000 psi max rating)
- Prime-Purge valves per channel, bulkhead-mounted outlet filters, and a low-volume, high-pressure mixing chamber (≤15 µL dead volume)
- Leak detection system with drip tray sensor and automatic pump halt upon fluid accumulation
- Modular Gradient Control Board featuring embedded firmware, non-volatile method storage, and autonomous operation post-download
Sample Compatibility & Compliance
The BLS CLASS accommodates a broad range of mobile phases—including aqueous buffers, organic modifiers (acetonitrile, methanol, THF), supercritical CO₂ (in SFC configurations), and corrosive solvents (e.g., TFA, HFIP)—when configured with compatible wetted materials. All fluidic components meet USP Class VI biocompatibility standards where applicable. The system supports GLP/GMP-aligned workflows through audit-trail-capable method logging, timestamped event records (valve actuations, pressure excursions, leak alerts), and configurable user access levels. While not pre-certified to FDA 21 CFR Part 11, the control board architecture permits implementation of electronic signature and data integrity controls when deployed within validated environments compliant with ISO/IEC 17025, ASTM E2500, or ICH Q2(R2).
Software & Data Management
The embedded SSI Gradient Control Board hosts a Windows-compatible GUI application for intuitive method design—including linear, stepwise, and multi-segment gradient profiles; flow ramping; timed valve switching; and conditional event triggers (e.g., “pause if pressure > 5,500 psi”). Methods are compiled and downloaded directly to onboard flash memory, enabling stand-alone execution without continuous PC connection. Communication interfaces include RS-232 (ASCII command protocol), Micro-USB (for firmware updates and diagnostics), analog voltage/current inputs for external process synchronization, and discrete digital I/O for integration with PLCs or system controllers. All status parameters—flow rate, pressure, valve position, temperature, and error codes—are accessible via serial query commands for SCADA or LIMS integration.
Applications
- Method development and optimization in reversed-phase, hydrophilic interaction (HILIC), and ion-pairing chromatography
- Preparative LC purification requiring stable flow under variable backpressure (e.g., column switching, fraction collection)
- Supercritical fluid chromatography (SFC) with CO₂/co-solvent binary gradients
- Multi-dimensional LC (LC×LC) where precise inter-system timing and flow coordination are essential
- Automated dissolution testing and continuous-flow reaction monitoring systems
- Calibration and verification of flow meters and pressure sensors in metrology laboratories
FAQ
What is the maximum operating pressure for PEEK-only fluid paths?
The BLS CLASS supports up to 5,000 psi when configured exclusively with PEEK tubing, seals, and pump heads.
Can the system operate without a connected computer after method upload?
Yes—the Gradient Control Board retains methods in non-volatile memory and executes them autonomously, including gradient profiling, valve sequencing, and leak response.
Is analog control supported for external process integration?
Yes—0–10 VDC and 4–20 mA inputs allow direct flow setpoint modulation from DCS or PLC systems.
How is flow accuracy verified during qualification?
Accuracy is validated per ASTM D3236 using gravimetric measurement of dispensed mass over time, with certified reference standards traceable to NIST SRM 2820.
Are replacement parts and service documentation available globally?
SSI provides OEM-certified spare kits (piston seals, check valves, dampeners), calibration certificates, and technical bulletins through authorized distributors in EMEA, APAC, and the Americas.
