METTLER TOLEDO XPE105 Advanced Analytical Balance

Overview

The METTLER TOLEDO XPE105 Advanced Analytical Balance is a high-precision weighing instrument engineered for laboratories requiring traceable, reproducible mass measurement at the 0.01 mg readability level. Built upon METTLER TOLEDO’s proprietary electromagnetic force compensation (EMFC) technology, the XPE105 delivers metrologically sound results under dynamic environmental conditions. Its core architecture separates the load cell and electronics into a thermally isolated rear compartment—minimizing thermal drift from operator proximity or ambient fluctuations. This design, combined with integrated Internal Temperature Control (ITC), ensures stable performance without external climate stabilization. The balance is developed in full alignment with Good Weighing Practice (GWP®), METTLER TOLEDO’s science-based framework for selecting, qualifying, calibrating, and operating weighing equipment in regulated environments—including pharmaceutical QC, reference material certification, and method validation labs.

Key Features

• SmartGrid™ Weighing Pan System: A perforated stainless-steel grid pan allows solid or liquid spills to pass through directly into a removable, dishwasher-safe drip tray—preventing contamination of internal mechanisms and preserving weighing accuracy during routine handling.
• StatusLight™ Visual Feedback System: A tri-color LED indicator provides real-time operational readiness: green (fully calibrated, level, and verified), yellow (pending scheduled TestManager verification), or red (error condition requiring intervention—e.g., imbalance, draft shield open, or sensor fault).
• Active Electrostatic Detection & Neutralization: Integrated electrostatic sensors identify surface charge on samples or containers; optional ionizer module (available as accessory) automatically neutralizes static up to ±2 kV, eliminating drift and particle dispersion—critical for low-mass powders, APIs, and nanomaterials.
• proFACT Advanced Auto-Calibration: Dual internal calibration masses enable temperature-compensated recalibration at user-defined intervals or triggered by ΔT thresholds—ensuring long-term traceability without manual intervention.
• Tool-Free Draft Shield & Modular Cleaning: Full glass draft shield detaches in <3 seconds without tools; all components—including pan, shield, and base—meet DIN EN ISO 15223-1 dishwasher safety standards for automated decontamination in GLP/GMP settings.

Sample Compatibility & Compliance

The XPE105 accommodates standard analytical vessels (vials, crucibles, weighing boats) up to 140 mm in diameter and 250 mm in height under the draft shield. Its minimum weight of 14 mg (per USP at k = 2) supports quantification of high-potency compounds and micro-dosed formulations. The balance complies with ISO/IEC 17025:2017 (clause 6.4.3 on equipment suitability), satisfies the uncertainty budget requirements of EURACHEM/CITAC Guide CG4, and enables formal GWP® qualification documentation. It supports audit-ready operation in FDA-regulated facilities when paired with LabX software configured for 21 CFR Part 11 compliance—including electronic signatures, role-based access control, and immutable audit trails for all calibration, testing, and weighing events.

Software & Data Management

LabX laboratory software serves as the central platform for SOP-driven weighing workflows, uncertainty calculation, and electronic record management. Preconfigured templates guide users through multi-step procedures (e.g., loss-on-drying, density determination, or formulation checks) directly on the XPE105’s capacitive touchscreen. All raw data—including timestamps, operator IDs, environmental logs (temperature/humidity), and calibration history—are captured automatically and stored in a secure SQL database. LabX generates PDF reports compliant with ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate + Complete, Consistent, Enduring, Available) and exports to LIMS or ERP systems via ODBC or REST API. Audit trail review functionality meets Annex 11 and PIC/S PI 041 requirements for electronic records in quality-critical processes.

Applications

• Pharmaceutical quality control: assay testing, content uniformity, residual solvent analysis sample preparation
• Reference standard weighing in metrology labs accredited to ISO/IEC 17025
• Chemical synthesis: stoichiometric reagent dosing and catalyst mass verification
• Materials science: precise loading of nanocomposites, battery electrode slurries, or thin-film precursors
• Food & beverage R&D: nutrient fortification dosing and allergen cross-contamination studies
• Environmental testing: filter weighing for PM2.5/PM10 gravimetric analysis per EPA Method IO-4.2

FAQ

What is the minimum weight requirement for reliable measurement on the XPE105?
The validated minimum weight is 14 mg (k = 2, based on repeatability per USP ). This value is dynamically updated in LabX if environmental conditions or usage patterns affect performance.
Does the XPE105 support external ionization for static elimination?
Yes—the balance detects electrostatic interference and can trigger an optional METTLER TOLEDO ESD-1000 ionizer via digital I/O interface; full integration is managed within LabX workflow logic.
How is traceability maintained across calibration and verification cycles?
All internal calibrations and TestManager verifications are timestamped, digitally signed, and archived with metadata (operator, environment, result, pass/fail status); reports include uncertainty budgets per GUM (JCGM 100:2008).
Can the XPE105 be integrated into a fully automated lab infrastructure?
Yes—it supports Ethernet/IP, RS232, and USB device mode for direct connection to robotic arms, dispensing systems, or central LIMS; LabX also provides OPC UA server capability for Industry 4.0 interoperability.
Is the SmartGrid pan compatible with corrosive or volatile solvents?
The 316L stainless-steel grid pan and PTFE-coated drip tray resist common organic solvents and mild acids; prolonged exposure to strong oxidizers (e.g., aqua regia) requires manual cleaning per METTLER TOLEDO Technical Note TN-2023-017.