Preparative Liquid Chromatography
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| Brand | Tongtian |
|---|---|
| Model | S500 |
| Origin | Shanghai, China |
| Instrument Type | Medium-Pressure Preparative LC System |
| Flow Rate Range | 1–200 mL/min |
| Flow Accuracy | ≤ ±2% |
| Flow Precision (RSD) | ≤ 1% |
| Maximum Operating Pressure | 20 MPa |
| Wavelength Options | 254 nm, 280 nm, 313 nm, 365 nm, plus two additional user-selectable wavelengths within ±1 nm tolerance |
| Wavelength Reproducibility | 0.2 nm |
| Baseline Noise | 1 × 10⁻⁵ AU |
| Data Acquisition Rate | 20 Hz |
| Sample Cell Volume | 70 µL |
| Optical Path Length | 3 mm |
| Standard Loop Volume | 10 mL (optional: 2 mL, 5 mL, 20 mL) |
| Pump Type | Dual-head piston pump with inert wetted materials |
| Detector Light Source | Deuterium (D₂) lamp |
| Compliance | Designed for GLP-compliant laboratory environments |
| Brand | Tongtian |
|---|---|
| Origin | Shanghai, China |
| Model | S501 |
| Application Level | Laboratory Grade |
| Instrument Type | Medium-Low Pressure Preparative LC System |
| Flow Rate Range | 1–200 mL/min |
| Flow Accuracy | ≤2% |
| Flow Precision (RSD) | ≤1% |
| Maximum Operating Pressure | 20 MPa |
| Wavelength Range | ±1 nm |
| Wavelength Repeatability | 0.2 nm |
| Baseline Noise | 1 × 10⁻⁵ AU |
| Data Acquisition Frequency | 20 Hz |
| Brand | Truelab |
|---|---|
| Origin | Beijing, China |
| Model | LC-3020 |
| Instrument Type | High-Pressure Preparative HPLC System |
| Flow Rate Range | 0.01–9.99 mL/min (analytical mode) |
| Flow Accuracy | ±0.14% (1 mL/min, deionized water, RT) |
| Flow Precision | 0.03% RSD (1 mL/min, deionized water, RT) |
| Max Pressure | 0–45 MPa (analytical) |
| Wavelength Range | 190–700 nm |
| Wavelength Accuracy | ±1 nm |
| Wavelength Repeatability | ±1 nm |
| Baseline Noise | 2×10⁻⁵ AU (254 nm, 1 mL/min, methanol) |
| Drift | 1×10⁻⁴ AU/h (254 nm, 1 mL/min, methanol) |
| Detection Limit | 4.7×10⁻⁹ g/mL (naphthalene, 254 nm, 1 mL/min, methanol) |
| Data Acquisition Rate | 5 Hz |
| Gradient Accuracy | ±1% |
| Detector Optical Path | 10 mm (standard), optional 2 mm / 1.25 mm / 0.5 mm flow cells |
| Pump Architecture | Dual-piston serial configuration with electronic pressure pulsation suppression |
| Control Interface | RS-232 and RS-485 |
| Software | Fully remote-controllable chromatography workstation with instrument parameter setting, method development, data acquisition, peak integration, and report generation |
| Brand | Unimicro Technologies |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | Original Equipment Manufacturer (OEM) |
| Product Category | Domestic |
| Model | EasySep-3220/3248 |
| Application Level | Laboratory-Scale |
| Instrument Type | Medium- to Low-Pressure Preparative LC System |
| Flow Rate Range | 0.1–200 mL/min |
| Maximum Operating Pressure | 200 psi |
| Brand | Vemex YMC |
|---|---|
| Origin | Japan |
| Model | K-Prep FC750 |
| Application Level | Industrial-Scale Preparation |
| Instrument Type | Medium- to Low-Pressure Preparative LC System |
| Flow Rate Range | 1–750 mL/min |
| Flow Accuracy | ±2% (at ≥75 mL/min) |
| Flow Precision | ≤0.5% RSD |
| Maximum Operating Pressure | 10 MPa |
| Wavelength Resolution | 1 nm |
| Data Acquisition Rate | 0.5 s |
| Compliance | GMP-Compliant Design, IQ/OQ-Ready, CSV-Aligned Software Architecture |
| Brand | Waters |
|---|---|
| Origin | USA |
| Manufacturer Type | Authorized Distributor |
| Product Category | Imported Instrument |
| Model | Analytical to Semi-Preparative HPLC Purification |
| Application Level | Laboratory Grade |
| Instrument Type | Medium-to-Low Pressure Preparative Liquid Chromatography |
| Flow Rate Capability | Up to 300 mL/min |
| Detection Options | UV-Vis PDA, ELSD, or Analog-Signal-Compatible Detectors |
| Fraction Collection | Waters Fraction Collector III |
| Column Technology | Optimized Bed Density (OBD) Columns |
| Software Platform | Empower Chromatography Data System (CDS) |
| Compliance Support | 21 CFR Part 11 Ready, GLP/GMP-Aware Workflow Design |
| Sample Load Range | Microgram-to-Milligram Scale |
| Brand | Waters |
|---|---|
| Origin | USA |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | AutoPurification |
| Application Level | Laboratory Grade |
| Instrument Type | High-Pressure Preparative Liquid Chromatography |
| UV/Vis Detection | Standard Configurable |
| MS Compatibility | Native HPLC/MS Integration |
| Fraction Collection | Automated, Signal-Triggered (UV, ELSD, MS, Analog) |
| Software Platform | FractionLynx™ |
| Column Technology | Optimized Bed Density (OBD) Columns |
| Scalability | Analytical-to-Preparative Upgrade Path |
| Automation Capability | Unattended Operation |
| Sample Throughput | Multi-hundred-sample Batch Processing |
| Loading Capacity | Milligram-to-Gram Scale Purification |
| Brand | Waters |
|---|---|
| Origin | USA |
| Model | 1525EF |
| Instrument Type | High-Pressure Semi-Preparative HPLC System |
| Application Level | Laboratory-Grade |
| Configuration | Dual-Flow Path Architecture (Analytical + Semi-Prep) |
| Sample Throughput | Single to High-Volume Batch Processing |
| Brand | Waters |
|---|---|
| Origin | USA |
| Model | Investigator SFC System |
| Application Level | Laboratory Grade |
| Instrument Type | Semi-Preparative Supercritical Fluid Chromatography System |
| Flow Rate Range | Up to 15 mL/min |
| Column Capacity | Up to 10 analytical columns or 6 preparative columns |
| Integrated Autosampler | Waters Alias |
| Software Platform | SuperChrom |
| Optional Detectors | 2998 Photodiode Array (PDA) Detector, 2424 Evaporative Light Scattering (ELS) Detector |
| Dimensions (H×L×W) | 92 cm × 98 cm × 68 cm |
| Regulatory Compliance | Designed for GLP/GMP-aligned workflows |
| Brand | Waters |
|---|---|
| Origin | USA |
| Model | Prep 100q SFC |
| Application Level | Laboratory Grade |
| Instrument Type | High-Pressure Preparative SFC System |
| Flow Rate Range | Up to 100 mL/min |
| Mobile Phase | CO₂-based supercritical fluid (co-solvent compatible) |
| Fraction Collection | Automated open-loop collection with UV- or MS-triggered modes |
| Compliance | Designed for GLP/GMP-aligned workflows |
| Separation Mode | Chiral and achiral preparative separations |
| Sample Scale | Milligram- to gram-scale purification |
| Brand | Waters |
|---|---|
| Origin | USA |
| Model | Prep 150 |
| Application Level | Laboratory-grade |
| Instrument Type | High-pressure preparative LC |
| Pump Configuration | Binary or Quaternary (low-pressure solvent selection or high-pressure gradient mixing up to 150 mL/min) |
| Detector Options | 2489 UV/Vis or 2998 Photodiode Array (PDA) |
| Column Compatibility | Up to 50 mm internal diameter |
| Sample Load Range | Milligram- to gram-scale purification |
| Software | ChromScope™ for method development, fraction simulation, and GLP-compliant data handling |
| Compliance | Designed to support 21 CFR Part 11–ready workflows with audit trail and electronic signature capability (when configured with appropriate IT infrastructure) |
| Brand | Waters |
|---|---|
| Origin | USA |
| Instrument Type | Preparative Supercritical Fluid Chromatography (SFC) System |
| Model Variants | 80, 200, 350 |
| Application Level | Laboratory-Scale Purification |
| Regulatory Context | Designed for GLP-compliant workflows and compatible with FDA 21 CFR Part 11–enabled software environments |
| Compliance Framework | Supports ASTM D7894–21 (Standard Guide for SFC Method Development), ISO 17025–2017 (Testing Laboratory Competence), and USP <621> Chromatography guidelines |
| Software Platform | SuperChrom v3.x (with audit trail, electronic signatures, and method versioning) |
| Detection | UV-Vis absorbance detection (dual-wavelength capability) |
| Fraction Collection | Automated, timed or peak-triggered, with solvent compatibility up to 100% CO₂-expanded liquids and polar modifiers (e.g., methanol, ethanol, isopropanol) |
| Back Pressure Control | Active Automatic Back Pressure Regulator (ABPR) with ±0.2 bar pressure stability |
| Solvent Delivery | Dual-pump architecture — primary CO₂ pump (supercritical phase delivery) and auxiliary modifier pump (liquid-phase co-solvent gradient) |
| System Architecture | Modular, rack-mounted configuration with integrated safety interlocks, CO₂ phase monitoring, and real-time density compensation |
| Brand | Agela |
|---|---|
| Origin | Tianjin, China |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Domestic |
| Model | WHALE HP |
| Application Level | Laboratory-Scale |
| Instrument Type | High-Pressure Preparative LC System |
| Flow Rate Range | 300–1000 mL/min |
| Flow Accuracy | ±3% |
| Pressure Rating | 10 MPa (pump max: 5 MPa) |
| UV-Vis Detection | PDA with 200–800 nm scanning range |
| Fraction Collection | 6-position valve-based collector + 1 solvent recovery channel |
| Column Compatibility | DAC columns (100–200 mm i.d.) or Flash cartridges (800–5000 g) |
| Sample Loading | Integrated liquid loading module, up to 1000 mL/min |
| Data Acquisition | Real-time spectral scanning and peak-triggered collection |
| Solvent Recovery Mode | Spectral purity assessment-enabled solvent reuse |
| Collection Modes | Full collection, peak collection, manual trigger, time-window collection |
| Brand | Wufeng |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | Authorized Distributor |
| Product Origin | Domestic (China) |
| Model | LC-100P |
| Price Range | USD 14,000–28,000 (FOB Shanghai) |
| Application Level | Laboratory-Scale Purification |
| Instrument Type | High-Pressure Preparative HPLC System |
| Flow Rate Range | 0.01–120 mL/min |
| Flow Accuracy | ±2% of set value |
| Flow Precision (RSD) | ≤0.2% |
| Maximum Operating Pressure | 42 MPa |
| Wavelength Range | 190–680 nm |
| Wavelength Accuracy | ±1 nm |
| Wavelength Repeatability | 0.1 nm |
| Baseline Noise | 2 × 10⁻⁵ AU (at 254 nm, 50 mL/min, methanol) |
| Baseline Drift | 2 × 10⁻⁴ AU/h (at 254 nm, 50 mL/min, methanol) |
| Data Acquisition Rate | 20 Hz |
| Communication Interface | RS-232 or USB |
| GLP Compliance Features | Deuterium lamp usage time logging, real-time lamp hour tracking, audit-ready operation logs |
| Brand | Yamazen |
|---|---|
| Origin | Japan |
| Manufacturer Type | Authorized Distributor (Global) |
| Product Category | Imported Instrument |
| Model | AI-580S |
| Application Level | Laboratory-Scale Purification |
| Instrument Type | Medium-Low Pressure Preparative HPLC System |
| Flow Rate Range | 0–80 mL/min |
| Flow Accuracy | RSD ≤ 1% (n = 6) |
| Flow Precision | RSD ≤ 1% (n = 6) |
| Maximum Operating Pressure | 1.0 MPa |
| Wavelength Range (UV Detector Options) | 254 nm fixed, or 190–380 nm / 190–600 nm variable |
| Wavelength Repeatability | ≤ ±0.1 nm |
| Baseline Noise | ≤ 1 × 10⁻⁵ AU |
| Data Acquisition Rate | 20 Hz |
| Brand | Yamazen |
|---|---|
| Origin | Japan |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | AI-700X |
| Application Level | Laboratory Grade |
| Instrument Type | Medium-Low Pressure Preparative LC |
| Flow Rate Options | 150 mL/min, 200 mL/min, 350 mL/min, 400 mL/min |
| Flow Accuracy | RSD₆ ≤ 1% |
| Flow Precision | RSD₆ ≤ 1% |
| Maximum Operating Pressure | 1.5 MPa |
| Wavelength Range | ±1 nm |
| Wavelength Repeatability | ≤0.1 nm |
| Baseline Noise | ≤1 × 10⁻⁵ AU |
| Data Acquisition Frequency | 20 Hz |
| Brand | Yamazen |
|---|---|
| Origin | Japan |
| Model | AKROS |
| Application Level | Laboratory Grade |
| Instrument Type | Medium-Low Pressure Preparative LC |
| Flow Rate Range | 0–80 mL/min |
| Flow Accuracy | RSD₆ ≤ 1% |
| Flow Precision (Repeatability) | RSD₆ ≤ 1% |
| Maximum Operating Pressure | 1.0 MPa |
| Wavelength Range | ±1 nm |
| Wavelength Repeatability | ≤0.1 nm |
| Baseline Noise | ≤1 × 10⁻⁵ AU |
| Data Acquisition Rate | 20 Hz |
| Brand | Yamazen |
|---|---|
| Origin | Japan |
| Model | W-Prep 2XY |
| Application Level | Laboratory Grade |
| Instrument Type | Medium-Low Pressure Preparative LC |
| Flow Rate Range | 0–80 mL/min |
| Flow Accuracy | RSD ≤ 1% (n = 6) |
| Flow Precision | RSD ≤ 1% (n = 6) |
| Maximum Operating Pressure | 1.0 MPa |
| Wavelength Range Options | 254 nm fixed / 190–380 nm / 190–600 nm |
| Wavelength Reproducibility | ≤ 0.1 nm |
| Baseline Noise | ≤ 1 × 10⁻⁵ AU |
| Data Acquisition Rate | 20 Hz |
| Brand | YMC |
|---|---|
| Origin | Japan |
| Model | DAU-50 |
| Maximum Operating Pressure | 10 MPa |
| Internal Diameter | 50 mm |
| Column Length | 700 mm |
| Bed Length Range | 100–400 mm |
| Axial Compression Mechanism | Hydraulic/Pneumatic Piston with Continuous Dynamic Load |
| Optional Slurry Delivery System Capacity | 2 L |
| Instrument Type | Medium-Low Pressure Preparative Liquid Chromatography System |
| Application Level | Laboratory-Scale Purification |
| Brand | YMC |
|---|---|
| Origin | Japan |
| Model | K-Prep EX |
| Application Level | Industrial-Scale Preparation |
| Instrument Type | Medium-to-Low Pressure Preparative LC System |
| Flow Rate Range | 30–3000 mL/min (EX03KG) |
| Flow Accuracy | ±2% (at ≥300 mL/min for EX03KG |
| Flow Precision | 0.5% RSD |
| Maximum Operating Pressure | 10 MPa |
| Wavelength Range | 195–600 nm |
| Wavelength Repeatability | ±1 nm |
| UV/VIS Detector | Fixed-wavelength or scanning, 1 nm resolution |
| Fraction Collection | 5-channel valve-switched system with drain line |
| Solvent Selection | 4-channel (2 × 2 configuration) |
| Control Interface | FA PC-based control (non-hazardous area), PLC-integrated architecture |
| Software Compliance | Developed per MHLW Japan’s “Guideline on Validation of Computerized Systems (CSV)” |
| Electrical Supply | 3-phase AC 200 V, 50/60 Hz (4.0–23 kW depending on model) |
| Construction Materials | High-purity SUS316 stainless steel tubing (ID: 7.5 mm to 22.1 mm), explosion-proof rated enclosures (ATEX / IECEx / Class I Div 1 compliant) |
| Brand | YMC |
|---|---|
| Origin | Japan |
| Model | K-Prep FC |
| Application Level | Industrial Preparative |
| Instrument Type | Medium-Low Pressure Preparative LC |
| Flow Rate Range | 1–750 mL/min |
| Flow Rate Reproducibility | ≤±2% (≥75 mL/min) |
| Maximum Pressure | 10 MPa |
| Wavelength Range | 195–600 nm |
| Gradient Capability | Isocratic & Gradient (FC750G / FC1500G variants) |
| Detection | UV/VIS |
| Pump Technology | Dual-plunger linear cam, pulse-free delivery |
| Column ID Compatibility | φ50–φ150 mm |
| Software Compliance | CSV-aligned per MHLW Japan “Guideline on Computerized Systems in GxP Environments” |
| Regulatory Alignment | Supports IQ/OQ protocols |
| Brand | YMC |
|---|---|
| Origin | Japan |
| Model | K-Prep LAB |
| Application Level | Laboratory-scale |
| Instrument Type | Medium-to-Low Pressure Preparative LC System |
| Flow Rate Range | 1–100 mL/min (LAB-100S/G) / 1–300 mL/min (LAB-300S/G) |
| Flow Accuracy | ±2% (≥10 mL/min for LAB-100 |
| Maximum Operating Pressure | 15 MPa (LAB-100 series) / 10 MPa (LAB-300 series) |
| UV Detection Wavelength Range | 195–370 nm |
| Gradient Capability | Dual-pump high-precision gradient formation |
| Sample Loop Capacity | 50 mL or 100 mL (configurable) |
| Injection Volume | Up to 25 mL via syringe (expandable with pump-assisted loading) |
| System Control | PC-based PLC-integrated software with audit trail |
| Compliance | Designed for GLP/GMP environments per FDA 21 CFR Part 11 and ISO/IEC 17025-aligned validation protocols |
| Column ID Compatibility | 20–200 mm |
| Packing Particle Size Support | 5–10 µm |
| Dead Volume | Minimized via motor-driven ball valves and low-ID stainless steel/FEP fluidic pathways |
| Power Supply | AC 100–240 V, 50/60 Hz |
| Power Consumption | 0.6 kW (single-pump) / 1.1 kW (dual-pump) |
| Brand | YMC |
|---|---|
| Origin | Japan |
| Model | LC-Forte/R |
| Application Level | Laboratory-scale |
| Instrument Type | Medium- to Low-Pressure Preparative LC System |
| Flow Rate Range | 0.1–50.00 mL/min |
| Flow Accuracy | ±2% (at ≥5 mL/min) |
| Flow Precision | ≤0.5% RSD |
| Maximum Pressure | 30 MPa |
| Wavelength Range | 190–400 nm (programmable, 1 nm step) |
| Wavelength Repeatability | ±0.5 nm |
| Baseline Noise | ≤1.3 × 10⁻⁴ AU (254 nm, 1 s response) |
| Data Acquisition Rate | 0.5 s per point |
| Detection Modes | UV-Vis (triple-wavelength simultaneous), optional RI detection |