AMTK AutoLiquid Platform – Benchtop High-Precision Liquid Handling System for Nucleic Acid Purification
| Origin | Beijing, China |
|---|---|
| Manufacturer Type | Authorized Distributor |
| Regional Origin | Domestic (PRC) |
| Model | AMTK AutoLiquid Platform |
| Pricing | Available Upon Request |
Overview
The AMTK AutoLiquid Platform is a benchtop, high-precision liquid handling system engineered specifically for nucleic acid purification workflows in molecular biology laboratories. It operates on positive displacement and air displacement pipetting principles, supporting reproducible, low-volume liquid transfers with minimal carryover and cross-contamination risk. Designed for integration into PCR setup, library preparation for next-generation sequencing (NGS), and automated DNA/RNA extraction protocols, the platform delivers consistent performance across diverse sample matrices—including whole blood, saliva, tissue lysates, and cultured cells. Its compact footprint (25 cm × 25 cm base area) enables deployment in space-constrained biosafety cabinets or laminar flow hoods, making it suitable for handling hazardous reagents under controlled containment conditions.
Key Features
- High-accuracy liquid handling from 0.1 µL to 500 µL per channel, validated per ISO 8655 standards for volumetric accuracy and precision
- Modular, open-architecture design—supports bidirectional integration via standard RS-232, USB 2.0, and Ethernet interfaces with third-party instruments including thermal cyclers, plate readers, magnetic bead separators, and centrifuges
- Dual-mode pipetting capability: single-channel and 8-channel parallel dispensing, compatible with standard SBS-format 96-well and 384-well plates, tubes, and reservoirs
- Integrated anti-drip and tip-touch detection algorithms to minimize residual droplet formation and ensure reliable tip ejection
- Robust mechanical architecture featuring stepper-motor-driven Z-axis control and linear encoders for repeatable vertical positioning (±5 µm repeatability)
- Onboard calibration routine accessible through GUI, supporting user-performed volume verification using gravimetric or photometric methods
Sample Compatibility & Compliance
The AMTK AutoLiquid Platform accommodates a broad range of biological sample types relevant to nucleic acid isolation: viscous lysates, ethanol-containing wash buffers, chaotropic salt solutions, and magnetic bead suspensions. It supports both spin-column–based and magnetic bead–based purification chemistries from major vendors (e.g., QIAGEN, Thermo Fisher, Zymo Research). All fluidic pathways are constructed from chemically inert PTFE and medical-grade stainless steel, ensuring compatibility with DNase/RNase-free protocols. The system complies with ISO/IEC 17025 requirements for laboratory equipment validation and meets essential safety criteria outlined in IEC 61010-1 for electrical equipment used in laboratory environments. While not pre-certified for GMP manufacturing, it supports GLP-compliant operation when deployed with audit-trail-enabled software configurations.
Software & Data Management
Controlled via the AMTK LiquidStudio™ desktop application (Windows 10/11, 64-bit), the platform provides intuitive workflow programming without scripting expertise. Users define protocols through drag-and-drop step sequencing—covering aspiration, dispense, mixing, delay, and plate movement commands—with real-time preview and dry-run simulation. The software logs all executed actions with timestamps, operator ID, protocol version, and environmental metadata (e.g., ambient temperature, humidity if external sensor integrated). Export formats include CSV, PDF, and XML, facilitating traceability in regulated environments. Optional add-ons enable 21 CFR Part 11 compliance, including electronic signatures, role-based access control, and immutable audit trails.
Applications
- Automated nucleic acid extraction from clinical specimens (e.g., nasopharyngeal swabs, plasma, FFPE tissues) prior to qPCR or digital PCR analysis
- NGS library preparation: fragmentation, end-repair, A-tailing, adapter ligation, and size selection steps with precise reagent metering
- High-throughput genotyping assay setup across 96- or 384-well formats
- Cell-based assay automation—including transfection reagent dispensing, media exchange, and cytotoxicity endpoint sampling—under sterile hood conditions
- Reagent consolidation and serial dilution for QC standards in diagnostic kit manufacturing
FAQ
What pipette tips are compatible with the AMTK AutoLiquid Platform?
Standard universal-fit, low-retention, filtered tips (10–1000 µL range) from major suppliers (e.g., Eppendorf, Rainin, VWR) are supported. Tip compatibility is verified against ANSI/SBS-1-2004 dimensional specifications.
Can the system be validated for use in clinical diagnostics?
Yes—when operated with documented IQ/OQ/PQ protocols and paired with Part 11–enabled software, the platform supports validation in CLIA- and CAP-accredited labs for non-IVD nucleic acid prep workflows.
Is remote monitoring or cloud-based protocol sharing available?
Local network monitoring is supported via HTTP API; cloud connectivity requires on-premise gateway deployment due to data sovereignty and HIPAA/GDPR considerations. Protocol libraries may be shared internally via SMB file sharing or network-mounted drives.
Does the platform support magnetic bead separation modules?
Yes—through optional side-mount brackets and TTL-triggered I/O ports, it interfaces directly with commercially available magnetic separation racks (e.g., DynaMag, KingFisher-compatible units) for fully automated bead-based purification.
What maintenance schedule is recommended?
Daily tip ejector cleaning and weekly Z-axis rail lubrication; biannual calibration verification and annual full-system performance qualification per AMTK Technical Bulletin LB-2023-04.
