BOXUN BSC-250 Temperature and Humidity Controlled Chamber

Overview

The BOXUN BSC-250 Temperature and Humidity Controlled Chamber is an upright environmental test chamber engineered for precision stability testing, accelerated aging studies, and long-term condition-controlled storage in pharmaceutical, biotechnology, food science, and materials research laboratories. It operates on a dual-parameter control principle—simultaneous regulation of air temperature and relative humidity via independent but coordinated refrigeration, heating, and humidification subsystems. The chamber employs a forced-air convection architecture with a centrifugal blower and proprietary airflow channeling to ensure uniform thermal and hygric distribution across the working volume. Its operational envelope—10–60°C at 50–90% RH—is aligned with ICH Q1A(R2) guidelines for long-term and accelerated stability testing of drug substances and products, as well as ASTM D4332 and ISO 2231 for conditioning of polymeric and textile specimens prior to mechanical evaluation.

Key Features

• Microprocessor-based digital controller with high-resolution LCD interface displaying real-time temperature, humidity, elapsed time, and setpoint; supports user-defined alarm thresholds and audible/visual over-temperature alerts.
• Integrated refrigeration system using internationally certified hermetic compressors and R134a-free refrigerant, compliant with EU F-Gas Regulation (EU) No 517/2014 and EPA SNAP program requirements.
• Patented non-energy-intensive auto-defrost cycle that activates only when frost accumulation is detected—minimizing thermal disturbance during extended uninterrupted operation.
• Finned electric humidifier with external 5-liter water reservoir enabling >72-hour continuous humidification without manual refilling; humidity sensor utilizes calibrated进口 capacitive RH transducer (±2% RH accuracy traceable to NIST standards).
• Stainless steel interior (mirror-finish 304 SS) with four height-adjustable load-bearing shelves; cold-rolled steel exterior with electrostatic epoxy-polyester coating for corrosion resistance.
• Dual-layer tempered glass observation window with anti-fog coating; two Φ30 mm (ID) / Φ60 mm (OD) access ports fitted with silicone gaskets for sensor insertion or cable routing under sealed conditions.
• RS-485 serial interface supporting Modbus RTU protocol for integration into centralized lab monitoring systems; data logging compatible with third-party SCADA platforms.

Sample Compatibility & Compliance

The BSC-250 accommodates standard ISO/IEC 17025-compliant sample configurations—including open petri dishes, capped vials, blister packs, and sealed pouches—without compromising chamber integrity or parameter stability. Its internal geometry (510 × 450 × 1100 mm) allows placement of up to four ISO-standard 250 mL Erlenmeyer flasks per shelf while maintaining ≥80 mm clearance from walls and ceiling for optimal air exchange. The chamber meets essential safety and performance criteria outlined in GB/T 10586–2018 (Chinese national standard for environmental test chambers), and its control architecture supports audit-ready operation under GLP and GMP frameworks—particularly when paired with optional PC monitoring software featuring 21 CFR Part 11–compliant electronic signatures, user access levels, and immutable audit trails.

Software & Data Management

The embedded controller stores up to 100 programmable profiles (30 segments × 99 cycles), each with independent ramp/soak parameters for temperature and humidity. All settings—including setpoints, alarms, and timer states—are retained after power interruption via non-volatile memory with automatic recovery logic. When connected via RS-485, the unit exports timestamped CSV-formatted datasets (T/°C, RH/%, status flags) at user-selectable intervals (1–60 min). Optional PC software provides graphical trend analysis, deviation reporting against ICH-defined limits, and PDF export of compliance-certified test reports. Thermal printer integration enables hard-copy archival of real-time curves meeting ISO/IEC 17025 documentation requirements.

Applications

• Pharmaceutical stability testing per ICH Q1A(R2), including long-term (25°C/60% RH), intermediate (30°C/65% RH), and accelerated (40°C/75% RH) protocols.
• Moisture sorption isotherm determination for excipients and active pharmaceutical ingredients (APIs) using gravimetric or dynamic vapor sorption (DVS)-correlated conditioning.
• Packaging permeability assessment under controlled climatic stress (e.g., evaluating barrier performance of blister foils or sachet laminates).
• Textile and polymer conditioning prior to tensile, tear, or abrasion testing per ASTM D1776 and ISO 139.
• Biological reagent storage validation, including lyophilized enzyme and antibody formulations requiring defined hygrothermal environments.
• Electronics component pre-conditioning for reliability screening (e.g., JEDEC J-STD-033 moisture sensitivity level (MSL) bake-out simulation).

FAQ

What is the maximum allowable ambient temperature for stable operation?
The BSC-250 is rated for continuous use in rooms maintained at ≤30°C and ≤70% RH ambient conditions. Operation above these limits may reduce cooling capacity and extend time-to-setpoint.
Can the chamber maintain 10°C at 90% RH?
Yes—within its specified operating envelope (10–60°C / 50–90% RH), the system dynamically balances refrigeration and humidification to achieve simultaneous low-temperature/high-humidity setpoints without condensation on samples.
Is calibration certificate included with shipment?
A factory calibration report (traceable to national metrology institutes) is provided. Full ISO/IEC 17025-accredited calibration services are available upon request.
How does the auto-defrost function avoid temperature overshoot?
Defrost cycles activate only during off-compressor periods and utilize residual heat from the evaporator coil—eliminating need for heater activation and preventing thermal spikes in the chamber cavity.
What is the warranty coverage?
Standard 24-month parts-and-labor warranty; extended service plans covering compressor, controller, and humidity system are available.