CETONI neMESYS Ultra-High-Pressure Precision Syringe Pump

Overview

The CETONI neMESYS Ultra-High-Pressure Precision Syringe Pump is an engineered fluid delivery system designed for applications demanding extreme pressure resilience, nanoliter-level dosing accuracy, and pulse-free flow stability. Based on a high-torque, low-vibration stepper motor architecture coupled with precision-machined lead-screw mechanics, the neMESYS platform eliminates mechanical oscillation during plunger advancement—ensuring laminar, non-pulsating displacement of viscous or shear-sensitive media. Its operational principle relies on closed-loop position control of the syringe plunger, where encoder feedback continuously corrects positional deviation, enabling reproducible volumetric delivery across pressure gradients up to 890 bar (13,000 psi). This makes it suitable for high-pressure liquid chromatography (HPLC), supercritical fluid processing, microfluidic actuation, and preclinical drug formulation where inertial artifacts or pressure transients must be rigorously suppressed.

Key Features

• Ultra-high pressure capability: Rated up to 890 bar with stainless-steel syringes (10–250 mL), validated per DIN EN ISO 15848-2 for leak-tightness under sustained load
• Nanoliter-resolution dosing: Minimum controllable flow rate of 12.0 nL/min using a 10 mL syringe, scalable across six standardized stainless-steel syringe volumes
• Vibration-damped drive system: Patented motor-mounting geometry and inertia-compensated acceleration profiles prevent acoustic coupling into sensitive optical or electrochemical detection setups
• Integrated safety interlock: Pressure-triggered mechanical cutoff guard activates automatically upon exceeding user-defined thresholds, compliant with IEC 61508 SIL2 functional safety requirements
• Modular synchronization: Up to 16 neMESYS units can be daisy-chained via EtherCAT bus, enabling coordinated multi-channel gradient generation or parallel sample injection
• Real-time flow calibration: Onboard temperature-compensated volumetric correction algorithm adjusts for thermal expansion of both syringe barrel and fluid medium

Sample Compatibility & Compliance

The neMESYS accommodates standard Luer-lock and ISO 8535-1-compliant stainless-steel syringes ranging from 10 mL to 250 mL. All wetted surfaces are electropolished AISI 316L stainless steel, certified for compatibility with organic solvents, aqueous buffers, and corrosive reagents including TFA, HFIP, and supercritical CO₂. The system meets CE marking requirements under Machinery Directive 2006/42/EC and Electromagnetic Compatibility Directive 2014/30/EU. For regulated environments, firmware supports 21 CFR Part 11-compliant electronic signatures, operator-level access control, and immutable audit trails—including timestamped parameter changes, pressure events, and emergency stop activations.

Software & Data Management

CETONI provides native software suites for Windows (Qmix Elements) and LabVIEW (Qmix SDK), offering both GUI-driven operation and programmatic integration. Qmix Elements includes graphical timeline-based protocol editing, real-time pressure/flow monitoring with configurable alarms, and CSV/TXT export with metadata embedding (e.g., syringe ID, calibration date, ambient temperature). The SDK supports Python, MATLAB, and C++ bindings, enabling integration into automated QC workflows or custom LIMS interfaces. All data files adhere to ASTM E2500-17 guidelines for raw data integrity, with SHA-256 checksums appended to exported datasets.

Applications

• Ultra-high-pressure liquid chromatography (UHPLC) method development requiring sub-100 µL/min flow stability at >700 bar
• Microreactor feeding in continuous-flow synthesis under supercritical conditions
• Precision metering of radiopharmaceuticals or cytotoxic compounds in GMP-grade isolator environments
• Calibration of piezoelectric dispensers and MEMS-based fluidic actuators
• Long-duration infusion studies in preclinical pharmacokinetic models (e.g., rat IV bolus + maintenance infusion)
• High-viscosity biopolymer extrusion for 3D bioprinting scaffold fabrication

FAQ

What syringe sizes are supported, and how does maximum pressure vary with volume?
Six syringe volumes are supported: 10, 25, 60, 75, 100, and 250 mL—all constructed from AISI 316L stainless steel. Maximum rated pressure decreases with increasing volume: 890 bar (10 mL), 345 bar (25 mL), 130 bar (60 mL), 100 bar (75 mL), 85 bar (100 mL), and 35 bar (250 mL), per DIN 12880-2 burst testing protocols.
Is the system compatible with third-party control systems beyond LabVIEW and Windows?
Yes—via EtherCAT master interface, the neMESYS accepts generic CoE (CANopen over EtherCAT) commands, enabling integration with Beckhoff TwinCAT, Siemens S7-1500 PLCs, or custom FPGA-based controllers.
How is flow accuracy verified and maintained over time?
Each unit ships with NIST-traceable gravimetric calibration certificates. Users may perform routine verification using CETONI’s Qmix Calibration Assistant, which guides through weight-based flow rate validation against analytical balances meeting OIML R76 Class II specifications.
Does the pump support bidirectional fluid movement (infusion and withdrawal)?
Yes—the neMESYS operates in fully reversible mode with identical accuracy and pressure rating in both directions, critical for recirculation loops or wash-rinse cycles in analytical systems.