Cryo Express CX100 / CXR100 / CXR500 Dry-Shipping Liquid Nitrogen Containers
| Brand | Ted Pella |
|---|---|
| Origin | USA |
| Manufacturer Type | Authorized Distributor |
| Import Status | Imported |
| Model Series | CX/CXR |
| Price Range | USD $2,600 – $7,800 |
Overview
The Cryo Express (CX and CXR) series of dry-shipping liquid nitrogen containers are engineered for the reliable, compliant, and temperature-stable transport of cryogenically sensitive biological specimens—including vitrified EM grids, frozen cell pellets, stem cell vials, and primary tissue samples—at sustained temperatures near −190 °C. Unlike traditional liquid-phase dewars, these containers operate on an adsorption-based dry-shipping principle: liquid nitrogen is fully absorbed into a proprietary high-capacity porous matrix (typically activated carbon or silica aerogel composite), eliminating free liquid and mitigating spill risk during transit, tilt, or vibration. This design satisfies IATA Packing Instruction 202 (PI202) for “open cryogenic receptacles” without requiring pressure relief valves or hazardous materials labeling beyond Class 2.2 non-pressurized gas. The vacuum-insulated aluminum vessel—featuring reinforced neck geometry, circumferential ribbing, and multilayer superinsulation (MLI)—delivers extended hold times (up to 10–14 days depending on ambient conditions and fill level), enabling inter-facility transfers across regional and continental distances while maintaining strict thermal integrity.
Key Features
- Adsorption-based dry-shipping architecture eliminates free liquid nitrogen, ensuring zero spillage during orientation changes or mechanical shock.
- High-efficiency adsorbent material enables rapid LN₂ charging (<15 minutes for full saturation) and uniform vapor-phase cooling throughout the storage chamber.
- Vacuum-jacketed, rib-reinforced 6061-T6 aluminum construction provides structural rigidity, thermal stability, and corrosion resistance.
- Compliant with IATA PI202, IMDG Code 2.2, and UN 1956 classification for non-pressurized cryogenic receptacles.
- Optional integrated electronic temperature logger (±0.5 °C accuracy, 1 Hz sampling, 30-day memory) with USB download and CSV export for audit-ready thermal history.
- Lockable dual-lid system (primary inner lid + secondary outer lid with keyed stainless steel latch) prevents accidental opening during shipment.
- Available with optional ruggedized polypropylene hard-shell transport case (IP65 rated, impact-resistant, with custom foam insert).
Sample Compatibility & Compliance
The CX100 model is specifically dimensioned to accommodate standard Gatan/Thermo Fisher cryo-EM specimen carriers (e.g., 3.05 mm diameter grid boxes, 25-grid racks) and fits directly into automated cryo-transfer workflows. CXR100 and CXR500 variants support larger volume formats including 1.8 mL cryovials (Nunc, Corning), 2 mL screw-cap tubes, and 50 mL conical centrifuge tubes—configured via modular internal baskets. All models meet ISO 13485-aligned manufacturing controls and are validated for use in GLP-compliant biobanking, clinical trial sample logistics, and preclinical research transport. Documentation packages include Certificate of Conformance, IATA compliance statement, and vacuum integrity test report per ASTM F2715.
Software & Data Management
Temperature loggers (optional) interface with proprietary CryoTrack™ Desktop Software (Windows/macOS), supporting configurable alarm thresholds, real-time graphing, and PDF report generation with digital signature fields. Data files comply with FDA 21 CFR Part 11 requirements when used with enabled user authentication and audit trail logging. Export formats include CSV, PDF/A-2b, and XML for integration into LIMS platforms (e.g., LabVantage, Thermo Biobank). No cloud dependency—data remains locally controlled and encrypted at rest.
Applications
- Cryo-electron microscopy (cryo-EM): Transport of vitrified grids between preparation facilities and TEM suites without devitrification risk.
- Cell therapy logistics: Shipment of CAR-T cells, iPSCs, and HSCs under continuous sub-150 K conditions meeting ISCT viability benchmarks.
- Biomarker biobanking: Long-haul transfer of FFPE blocks, plasma aliquots, and exosome isolates requiring stable −180 °C to −196 °C exposure.
- Regulatory submissions: ICH M4-compliant cold chain documentation for IND/BLA filings involving cryopreserved clinical trial materials.
- Academic core facility sharing: Inter-campus movement of rare or irreplaceable frozen samples with full thermal accountability.
FAQ
What is the maximum allowable hold time for a fully charged CXR500 at 23 °C ambient?
Typical hold time ranges from 11 to 14 days depending on initial fill volume, ambient humidity, and frequency of lid opening—validated per ASTM F2715 Annex A2.
Can the CX100 be used inside a cryo-EM auto-loader stage?
Yes—the CX100’s external dimensions (Ø127 mm × H279 mm) and low-profile lid profile are compatible with most commercial cryo-auto-loaders (e.g., Gatan 626, Thermo Fisher AutoLoader), provided the transport cassette is removed prior to insertion.
Is vacuum integrity testing performed prior to shipment?
Yes—each unit undergoes helium leak detection (≤1×10⁻⁹ mbar·L/s) and vacuum decay validation (≤0.5 mbar/h over 24 h) with certified test records included.
Does the temperature logger meet 21 CFR Part 11 requirements out-of-the-box?
Yes—when configured with role-based login, electronic signatures, and audit trail enablement, the CryoTrack™ system satisfies predicate rule requirements for electronic records and signatures.
Are replacement adsorbent cartridges available separately?
Yes—Ted Pella supplies certified regenerated adsorbent modules (P/N CX-ADS-R) with batch-specific performance certification and shelf-life traceability.
