EYELA N-1100D-W Rotary Evaporator

Overview

The EYELA N-1100D-W Rotary Evaporator is a precision-engineered, compact benchtop system designed for efficient solvent removal, concentration, and gentle sample recovery under reduced pressure. Based on the fundamental principle of rotary evaporation—where reduced pressure lowers the boiling point of solvents while controlled heating and continuous rotation increase surface area and mass transfer—the N-1100D-W delivers reproducible performance in synthetic chemistry, natural product isolation, pharmaceutical development, and quality control laboratories. Its vertical dual-layer coiled condenser architecture optimizes thermal exchange efficiency without requiring excessive bench space, making it especially suitable for laboratories with spatial constraints yet demanding rigorous process control and contamination minimization.

Key Features

• Compact vertical condenser design: Engineered with an optimized coil geometry that increases effective cooling surface area by 30% (0.146 m² total) compared to conventional straight-tube configurations—enabling high condensation efficiency even at elevated evaporation rates up to 18 mL/min.
• Two-stage manual lift mechanism: Combines a primary 100 mm smooth-thread lifting system with an auxiliary 150 mm telescopic slide extension at the upper housing—allowing precise positioning of small-volume flasks or buffer vessels relative to the vapor path without reconfiguration.
• Dual-material vacuum sealing: Standard PTFE/fluoroelastomer composite gasket ensures long-term chemical resistance against aggressive organic solvents (e.g., chloroform, THF, acetone) and maintains stable vacuum integrity below 400 Pa (3 mmHg).
• Thermally protected heating bath: 1 kW immersion heater with microprocessor-based ON-OFF control and ±1.5°C accuracy (water bath) supports stable temperature regulation across the full range of RT+5°C to 90°C—critical for thermolabile compound handling.
• Integrated anti-backflow protection: Built-in check valve prevents solvent backflow into the evaporation flask during vacuum release or pump shutdown, reducing cross-contamination risk and improving operational safety.
• Modular compatibility: Designed for seamless integration with EYELA’s NVC-series vacuum controllers (optional), enabling automated pressure ramping and endpoint detection to enhance yield consistency and reduce operator intervention.

Sample Compatibility & Compliance

The N-1100D-W accommodates standard ground-glass jointed glassware including 1 L pear-shaped evaporation flasks (29/38 taper) and 1 L spherical receiving flasks (S35/20). With optional adapters, it supports volumetric capacities up to 3 L. All wetted components—including seals, condenser tubing, and rotary shaft—are chemically inert to common laboratory solvents per ASTM D471 and ISO 1817 standards. The unit complies with IEC 61010-1:2010 for electrical safety in laboratory equipment and incorporates dual redundant safety systems: a thermal fuse and a dedicated dry-run prevention sensor that deactivates heating if bath fluid level falls below operational threshold. While not certified for GMP manufacturing environments, its repeatable temperature/vacuum profiles support GLP-aligned documentation workflows when paired with external data loggers.

Software & Data Management

The N-1100D-W operates as a standalone instrument with no embedded software or network interface. Temperature setpoint and real-time bath temperature are displayed digitally via a membrane keypad interface; all parameters are manually entered and retained through power cycles. For regulated environments requiring audit trails (e.g., FDA 21 CFR Part 11 compliance), users may integrate third-party environmental monitoring systems using analog output signals (if equipped with optional analog interface module) or employ time-synchronized external logging of vacuum, temperature, and rotation data. EYELA provides calibration certificates traceable to JIS Z 8000 series standards upon request.

Applications

• Solvent removal from reaction mixtures post-Suzuki coupling or Grignard synthesis
• Concentration of natural extracts (e.g., plant alkaloids, essential oils) without thermal degradation
• Recovery and recycling of low-boiling solvents such as diethyl ether, pentane, and dichloromethane
• Preparative-scale purification prior to HPLC or crystallization steps
• Removal of residual solvents from polymer solutions or nanoparticle dispersions
• Routine QC testing in pharmaceutical stability studies requiring consistent evaporation endpoints

FAQ

What is the maximum recommended flask size for the N-1100D-W?

The standard configuration supports a 1 L pear-shaped flask (29/38); however, the system is mechanically rated for flasks up to 3 L with appropriate support stands and balanced rotation.
Can the N-1100D-W be used with oil baths?

Yes—its temperature range extends to 90°C in water and higher ranges (up to 180°C) in compatible silicone or mineral oil media when configured as the N-1100D-WD variant; temperature accuracy degrades to ±3.0°C under oil-bath conditions.
Is the condenser removable for cleaning?

The vertical double-layer condenser is fixed-integrated but accessible via front-panel disassembly; PTFE-lined internal surfaces resist residue buildup and permit routine rinsing with compatible solvents.
Does the unit include a vacuum pump?

No—vacuum generation requires an external diaphragm or rotary vane pump; optimal performance is achieved with pumps capable of sustaining ≤100 Pa base pressure.
How often should the PTFE/fluoroelastomer seal be replaced?

Under typical usage (daily operation, moderate solvent exposure), replacement is recommended every 6–12 months or immediately upon visible compression set, cracking, or vacuum leakage exceeding 10 Pa/min drift.