Hanuo HN-30K Handheld High-Shear Homogenizer

Overview

The Hanuo HN-30K Handheld High-Shear Homogenizer is an engineered solution for rapid, reproducible sample disruption and dispersion in research and quality control laboratories. Based on rotor-stator shear principle, the device generates intense hydrodynamic cavitation and mechanical shear forces within the narrow gap between a rotating probe tip and stationary sleeve—effectively disrupting cellular membranes, emulsifying immiscible phases, and deagglomerating nanoparticles. Its compact form factor and ergonomic grip enable precise control during direct immersion into sample vessels ranging from microcentrifuge tubes to 250 mL beakers. Designed for routine use in life science and industrial R&D settings, the HN-30K delivers consistent performance across biological tissues (e.g., liver, muscle, mammary gland), suspension-based nanomaterials, oil-in-water emulsions, and viscous cosmetic formulations—achieving complete homogenization in as little as 10–30 seconds under optimized conditions.

Key Features

• Ergonomic handheld design with balanced weight distribution (0.7 kg) for extended single-hand operation without operator fatigue.
• Variable speed control (8,000–35,000 rpm) with instant response and stable torque delivery, minimizing sample splashing and thermal degradation.
• Two standardized stainless-steel probe options: 6 mm probe for low-volume applications (0.1–50 mL); 10 mm probe for higher throughput (1–250 mL), both autoclavable at 121 °C for GLP-compliant workflows.
• High-efficiency brushless motor with thermal protection circuitry ensures long service life and consistent rotational accuracy over repeated duty cycles.
• Quick-release probe coupling mechanism enables tool-free disassembly within seconds for thorough cleaning and cross-contamination prevention.
• IP30-rated housing provides protection against vertically falling solid objects, supporting safe benchtop use in standard laboratory environments.

Sample Compatibility & Compliance

The HN-30K accommodates a broad spectrum of sample matrices—including soft and fibrous animal tissues, bacterial cell pellets, polymer dispersions, pigment suspensions, and surfactant-stabilized emulsions. Its rotor-stator geometry is compatible with common labware such as Eppendorf tubes, glass vials, conical centrifuge tubes, and small beakers. While not certified to IEC 61000-6-3 or UL 61010-1 for clinical diagnostics, the instrument meets general safety requirements for Class II laboratory equipment per EN 61010-1:2010. It supports adherence to internal SOPs aligned with ISO/IEC 17025 quality management systems and facilitates traceable processing when used in conjunction with documented protocols for tissue lysis (per ASTM D7215-16) or nanoparticle dispersion (per ISO/TS 80004-5:2011).

Software & Data Management

The HN-30K operates as a standalone analog-controlled instrument without embedded firmware or digital connectivity. All operational parameters—including speed setting, duration, and probe type—are manually recorded by the user. For auditability in regulated environments (e.g., pharmaceutical QC labs), integration with external timing devices and electronic lab notebooks (ELNs) is recommended. The absence of onboard memory or network interfaces eliminates data integrity risks associated with unvalidated software; this architecture aligns with FDA 21 CFR Part 11 principles where manual entry and procedural controls are sufficient for non-critical process steps.

Applications

• Biological sample preparation: rapid lysis of mammalian tissues, microbial cells, and plant material prior to nucleic acid extraction or protein isolation.
• Nanomaterial processing: uniform dispersion of carbon nanotubes, metal oxides, and quantum dots in aqueous or organic media.
• Pharmaceutical formulation development: stabilization of nanoemulsions, liposomes, and self-emulsifying drug delivery systems (SEDDS).
• Food & dairy testing: homogenization of milk fat globules, yogurt suspensions, and infant formula simulants for particle size analysis.
• Environmental analysis: extraction of contaminants from sediment slurries or biofilm samples prior to GC-MS or ICP-MS detection.
• Chemical synthesis support: intensification of heterogeneous catalytic reactions and polymerization initiation in small-scale batch reactors.

FAQ

What is the maximum continuous operating time per cycle?
The HN-30K is rated for intermittent use—up to 60 seconds per activation followed by ≥30 seconds of cooling. Continuous operation beyond 90 seconds may trigger thermal cutoff.
Can the probe be sterilized using ethylene oxide (EtO)?
Yes, both 6 mm and 10 mm stainless-steel probes are compatible with EtO sterilization per ISO 11135; however, repeated exposure may affect surface passivation—autoclaving remains the preferred method.
Is the HN-30K suitable for high-viscosity samples (>500 mPa·s)?
It is optimized for low-to-medium viscosity liquids (<200 mPa·s). For viscous pastes or gels, pre-dilution or use of the 10 mm probe at lower speeds (≤15,000 rpm) is advised to avoid motor overload.
Does the unit include calibration documentation?
No factory calibration certificate is supplied, as speed verification requires external tachometric measurement. Users should perform periodic speed validation using a handheld optical tachometer per ISO/IEC 17025 Clause 6.5.
What mounting accessories are available?
An optional H-type adjustable stand (sold separately) allows fixed-angle positioning and height adjustment between 150–400 mm, enabling hands-free operation during repetitive tasks or timed homogenization protocols.