Masterflex® L/S® High-Pressure Peristaltic Pump System

Overview

The Masterflex® L/S® High-Pressure Peristaltic Pump System (Model 77914-10) is an engineered solution for precise, contamination-free fluid handling in demanding laboratory and pilot-scale applications. Based on the well-established peristaltic principle—where rollers compress a flexible tubing to generate positive displacement—the system delivers consistent, pulse-minimized flow without exposing fluids to valves, gears, seals, or diaphragms. This design ensures complete fluid isolation within the tubing, eliminating cross-contamination risks and simplifying cleaning validation. Engineered for sustained operation at up to 150 psi (10.2 bar), the L/S® platform exceeds standard peristaltic performance thresholds, making it suitable for high-backpressure scenarios such as inline filtration, chemical dosing into pressurized reactors, and sterile media transfer across bioprocessing workflows.

Key Features

• High-pressure capability: Continuous operation at up to 150 psi (10.2 bar), enabled by reinforced L/S®-series pump tubing and optimized roller geometry.
• Precision speed control: Digital keypad interface with 3-digit LED display; adjustable speed range from 1 to 100 rpm with ±0.25% accuracy (±1 rpm) under load.
• Reversible DC motor: Integrated soft-start and back-EMF compensation ensure smooth acceleration/deceleration and extended motor service life.
• Modular architecture: Single-head configuration supports interchangeable L/S® pump heads (e.g., L/S® 73, L/S® 74) for rapid adaptation to different tubing sizes and flow requirements.
• Robust enclosure: Flame-retardant ABS housing rated IP33—protecting against vertically falling drips and solid objects ≥2.5 mm—suitable for general lab environments.
• Universal power compatibility: Auto-ranging 90–260 VAC, 50/60 Hz input with IEC 320 C13 inlet; includes 1.8 m power cord with CEE 7/7 (Schuko) plug.
• Stackable design: Compact footprint (25.4 × 21.6 × 21.6 cm) enables vertical stacking for space-constrained installations without thermal or mechanical interference.

Sample Compatibility & Compliance

The system is compatible with all Masterflex L/S®-rated tubing materials—including PharMed® BPT, Norprene®, and Viton®—each validated for chemical resistance, low extractables, and USP Class VI compliance. Fluid contact is limited exclusively to the tubing interior, enabling seamless use in GMP-regulated environments where material traceability and leachables control are critical. The pump meets CE marking requirements and carries UL recognition for electrical safety (UL 61010-1). While not inherently 21 CFR Part 11 compliant, its analog control architecture supports integration into validated systems when paired with external audit-trail-capable SCADA or LIMS platforms. It conforms to ISO 8573-1 for compressed air–free operation and ASTM D4169 for packaging integrity testing protocols requiring controlled liquid delivery.

Software & Data Management

This standalone analog-driven system does not include embedded firmware, network connectivity, or proprietary software. All operational parameters—including direction, speed setpoint, and runtime—are configured locally via the front-panel keypad. For automated process integration, optional analog (0–10 VDC or 4–20 mA) and digital (TTL-level start/stop) I/O interfaces are available through accessory modules (sold separately). When deployed in regulated settings, users typically log operating conditions manually or via external data acquisition systems. The absence of internal memory or user-accessible configuration storage simplifies IQ/OQ documentation and eliminates electronic record retention obligations under FDA 21 CFR Part 11—making qualification straightforward for QC labs and GLP-compliant facilities.

Applications

• Chemical injection into high-pressure reactors or chromatography systems
• Sterile filtration feed for tangential flow (TFF) and depth filtration units
• Accurate metering of reagents, buffers, or cell culture media in biomanufacturing
• Continuous sampling in environmental monitoring stations with elevated line pressure
• Pharmaceutical formulation development requiring solvent-resistant, non-metallic fluid paths
• Academic research involving corrosive, viscous, or shear-sensitive fluids where pump longevity and repeatability are essential

FAQ

What tubing sizes are supported by the 77914-10 driver?
The Model 77914-10 accommodates any single L/S®-series pump head, including those designed for tubing inner diameters from 0.13 mm to 3.2 mm (e.g., L/S® 73 for 0.13–1.6 mm; L/S® 74 for 0.76–3.2 mm).
Can this pump be used in a cleanroom environment?
Yes—provided appropriate USP Class VI–certified tubing (e.g., PharMed® BPT) is installed and the unit remains outside the ISO Class 5–8 envelope while feeding through pass-through ports.
Is the pump suitable for abrasive slurries?
Not recommended for undiluted abrasives; however, it performs reliably with low-solids suspensions (<5% w/v) when using reinforced Norprene® or silicone-reinforced tubing.
Does the system support timed dispensing or volume-based dispensing?
No built-in volumetric control; however, volume can be calculated and verified using calibrated tubing and confirmed rotational speed, then executed via external timer or PLC signal.
What maintenance is required?
Routine inspection of tubing wear and periodic replacement (typically every 100–500 hours depending on speed, pressure, and fluid); no lubrication or calibration is required for the motor or drive mechanism.