Metash X-6DS Dual-Beam UV-Vis Spectrophotometer

Overview

The Metash X-6DS is a high-performance dual-beam ultraviolet-visible (UV-Vis) spectrophotometer engineered for precision absorbance, transmittance, and reflectance measurements across a broad spectral range (190–1100 nm). Its dual-beam optical architecture continuously compares sample and reference beam intensities in real time, effectively compensating for source drift, detector instability, and environmental fluctuations—thereby delivering exceptional baseline stability and measurement reproducibility over extended operational periods. The instrument employs a robust suspended optical design, with the entire optical path rigidly mounted on a 10 mm thick machined aluminum baseplate. This structural isolation minimizes sensitivity to mechanical vibration and thermal deformation, ensuring long-term photometric integrity essential for regulated laboratory environments.

Key Features

• Dual-beam optical system with real-time reference compensation for enhanced photometric stability and reduced baseline drift
• 7-inch high-resolution capacitive touchscreen interface with intuitive icon-driven navigation and responsive multi-touch operation
• Four selectable spectral bandwidths (0.8, 1.8, 4.0, and 5.0 nm) to optimize resolution versus signal-to-noise ratio depending on sample matrix and analytical objective
• Integrated high-stability light source assembly featuring imported long-life deuterium and tungsten-halogen lamps with automatic lamp switching at 340 nm
• Motorized wavelength drive with ±0.5 nm accuracy and ≤0.2 nm repeatability, validated per ISO 8579 and ASTM E275
• Low stray light performance (≤0.05%T at 220 nm and 340 nm), critical for accurate quantitation of highly absorbing or turbid samples
• Photometric accuracy of ±0.3%T (0–100%T) and repeatability of ≤0.15%T, supporting compliance with pharmacopeial methods (e.g., USP )

Sample Compatibility & Compliance

The X-6DS accommodates standard 10 mm pathlength cuvettes and supports optional accessories including automated multi-cell changers (6–8 position), micro-volume holders (down to 50 µL), Peltier-controlled temperature-regulated cells (±0.1 °C), integrating sphere reflectance modules, and rotating solid-sample stages. All hardware and firmware comply with IEC 61010-1 safety standards and electromagnetic compatibility (EMC) requirements per EN 61326-1. Software architecture adheres to GLP/GMP principles: user-level access control (admin/operator/guest), full audit trail with timestamped event logging (login/logout, method changes, data exports), electronic signature support, and immutable data storage with versioned backups—fully compatible with FDA 21 CFR Part 11 readiness when deployed with validated network infrastructure.

Software & Data Management

The included Metash SpectraScan software provides comprehensive PC-based control and advanced post-acquisition analysis. In addition to replicating all standalone instrument functions—including photometric mode, quantitative analysis (single/multi-point calibration, equation fitting), kinetic assays, spectral scanning (up to 3200 data points), DNA/protein A₂₆₀/A₂₈₀ ratio calculation, and multi-wavelength quantification—the software enables derivative spectroscopy, peak identification, spectral subtraction, and customizable report generation. Raw spectral data are stored in vendor-neutral CSV and JCAMP-DX formats. Internal memory capacity exceeds 10,000 spectra; data export is supported via USB 2.0 port to FAT32-formatted flash drives. Optional Bluetooth 4.2 module enables wireless connection to certified printers and peripheral devices without compromising network security protocols.

Applications

The X-6DS serves as a core analytical platform in quality control laboratories across pharmaceutical, biotechnology, food & beverage, environmental, and academic research sectors. Typical use cases include: validation of active pharmaceutical ingredient (API) concentration per USP/EP monographs; verification of excipient purity and degradation kinetics; nucleic acid and protein quantification using extinction coefficient-based calculations; colorimetric enzyme assay development (e.g., ELISA, LDH); heavy metal analysis via complexometric spectrophotometry (e.g., Fe²⁺ with 1,10-phenanthroline); and routine water quality testing (nitrate, phosphate, COD). Its low stray light and high photometric linearity make it suitable for measuring high-absorbance samples (A > 3.0) without dilution errors.

FAQ

Does the X-6DS support regulatory-compliant data handling?
Yes—the embedded software implements full GLP/GMP functionality including role-based user authentication, tamper-evident audit trails, electronic signatures, and secure data archiving compliant with FDA 21 CFR Part 11 when operated within a validated IT environment.

What is the maximum scan speed and resolution achievable?
Scanning speed is adjustable from 100 to 3000 nm/min; spectral resolution is determined by selected bandwidth (0.8 nm minimum) and sampling interval (default 1.0 nm, configurable down to 0.1 nm).

Can the instrument be integrated into LIMS or enterprise lab networks?
Yes—via USB virtual COM port emulation or optional Ethernet interface (firmware v2.3+), enabling bidirectional communication with LIMS using ASTM E1384 or HL7-compatible middleware.

Is routine maintenance required for optical alignment?
No—optical alignment is factory-performed and mechanically locked; no user-accessible collimation screws or mirror adjustments are provided, eliminating drift-related recalibration needs during normal operation.