METTLER TOLEDO ME104E Analytical Balance
| Brand | METTLER TOLEDO |
|---|---|
| Origin | Shanghai, China |
| Model | ME104E |
| Instrument Type | Analytical Balance |
| Maximum Capacity | 120 g |
| Readability | 0.1 mg |
| Repeatability | 0.08 mg |
| Linearity | ±0.2 mg |
| Calibration Method | External (with optional calibration weights) |
| Pan Size | 90 mm diameter |
| Draft Shield Height | 220 mm |
| Dimensions (W×D×H) | 210 × 344 × 344 mm |
| Construction | Robust metal chassis with high-grade polymer housing |
Overview
The METTLER TOLEDO ME104E Analytical Balance is an entry-level precision instrument engineered for routine laboratory weighing tasks requiring high reproducibility and long-term stability. Based on electromagnetic force compensation (EMFC) technology, it delivers traceable mass measurements in accordance with international metrological principles defined in OIML R76 and ISO/IEC 17025. With a readability of 0.1 mg and a maximum capacity of 120 g, the ME104E operates within the standard analytical range required for quantitative sample preparation, reagent dispensing, formulation verification, and quality control testing in pharmaceutical, chemical, academic, and food laboratories. Its design integrates core METTLER TOLEDO engineering principles—including temperature-compensated load cell architecture, optimized damping algorithms, and low-drift electronics—to ensure consistent performance across ambient fluctuations typical in non-climate-controlled lab environments.
Key Features
- Electromagnetic force compensation (EMFC) sensor system delivering stable, drift-minimized readings under variable thermal conditions
- Ergonomic front-access design with intuitive single-button operation for tare, unit change, and zero functions
- Integrated level indicator and adjustable front leveling feet for rapid mechanical alignment—critical for accuracy at sub-milligram resolution
- Durable metal chassis reinforced with impact-resistant polymer housing, supporting daily use in high-throughput QC labs
- Removable draft shield with 220 mm effective height, enabling stable weighing of volatile or hygroscopic samples without turbulence interference
- 90 mm stainless steel weighing pan optimized for compatibility with standard labware including weighing boats, crucibles, and volumetric flasks
- External calibration capability using certified Class M1 or better weights—fully compliant with ISO 9001 internal audit requirements
Sample Compatibility & Compliance
The ME104E accommodates a broad spectrum of solid and granular samples, including powders, tablets, reference standards, and small-volume liquid containers. Its open-front geometry and low-profile base facilitate seamless integration with pipettes, dispensers, and automated sample handlers. From a regulatory standpoint, the balance supports GLP and GMP workflows through documented calibration procedures and user-accessible calibration logs. While the ME104E does not include built-in 21 CFR Part 11 compliance features (e.g., electronic signatures or audit trails), its external calibration protocol aligns with FDA expectations for manual record-keeping in non-critical applications. It meets ASTM E898–22 for general-purpose analytical balance verification and conforms to ISO 17025 clause 6.4.3 regarding equipment suitability and verification.
Software & Data Management
The ME104E operates as a standalone instrument with no embedded software or connectivity options. All data output is limited to real-time display on the integrated LCD screen. For traceable documentation, users must manually record results or connect via RS232 interface (optional cable required) to third-party lab information systems (LIMS) or spreadsheet applications. The balance supports standard ASCII transmission protocols compatible with common serial-to-USB adapters. No proprietary drivers or firmware updates are provided; calibration parameters remain fixed post-factory configuration. This architecture prioritizes operational simplicity and reduces validation overhead in regulated environments where software qualification is resource-intensive.
Applications
- Preparation of standard solutions and calibration standards in analytical chemistry labs
- Weighing of active pharmaceutical ingredients (APIs) during formulation development and batch release testing
- Moisture content determination via gravimetric loss-on-drying (LOD) protocols
- Quality assurance of raw materials, excipients, and finished dosage forms per USP & Ph. Eur. monographs
- Teaching laboratories requiring robust, serviceable instruments for student training in metrology fundamentals
- Environmental testing labs performing filter weighing for particulate matter (PM10/PM2.5) analysis
FAQ
What is the recommended calibration frequency for the ME104E in a regulated environment?
Calibration should be performed before each critical weighing session and after any relocation or environmental disturbance—per ISO/IEC 17025 Clause 6.4.3 and USP General Chapter <1251>. Daily verification using a check weight is strongly advised.
Can the ME104E be used for dynamic or moving-load applications?
No. This balance is designed exclusively for static mass measurement. It lacks vibration compensation or motion-tolerance algorithms required for conveyor-based or robotic integration.
Is the draft shield removable for cleaning?
Yes—the acrylic draft shield is fully detachable and autoclavable up to 60 °C, supporting routine decontamination in microbiology or cleanroom settings.
Does the ME104E support internal calibration?
No. Internal calibration is not available on this model; only external calibration using traceable weights is supported.
What environmental conditions affect measurement stability?
Ambient temperature gradients exceeding ±1 °C/hour, air currents >0.2 m/s, and electrostatic charge accumulation on samples may introduce deviations beyond stated repeatability specifications.
