Millipore Elix 20 Water Purification System
| Brand | Millipore |
|---|---|
| Origin | France |
| Model | Elix 20 |
| Pure Water Grade | ASTM Type II (Analytical Grade) |
| Resistivity | >5 MΩ·cm @ 25°C |
| Heavy Metals & Soluble Silica | <0.1 ppb |
| Total Organic Carbon (TOC) | <30 ppb |
| Microbial Contamination | <0.001 CFU/mL |
| Endotoxins | <0.001 EU/mL |
| Particles (>0.1 µm) | <1 particle/mL |
| Maximum Daily Output | 4,000 L |
Overview
The Millipore Elix 20 Water Purification System is an engineered solution for the continuous production of high-purity Type II analytical-grade water from municipal tap feedwater. Utilizing a multi-stage purification architecture—comprising pre-filtration, activated carbon adsorption, reverse osmosis (RO), and patented Electrodeionization (EDI) with continuous current regeneration—the Elix 20 delivers consistent, reliable output meeting or exceeding international standards including ASTM D1193 Type II, ISO 3696 Grade 2, BS 3979, USP Purified Water monograph, and EP 2.2.43. Designed for laboratory environments requiring stable, low-maintenance water supply at scale, the system operates without chemical regeneration, minimizing operational downtime and consumable handling. Its modular construction supports integration into centralized distribution networks, enabling simultaneous delivery to multiple points-of-use while maintaining full parameter traceability and real-time monitoring.
Key Features
- Patented Elix EDI module with continuous current regeneration—eliminates need for periodic resin replacement or chemical regeneration cycles
- Integrated dual-parameter monitoring: real-time resistivity measurement (>5 MΩ·cm at 25°C) and on-line TOC detection (<30 ppb)
- UV lamp (185/254 nm) integrated in recirculation loop to suppress microbial proliferation and photolyze low-molecular-weight organics
- Pre-treatment cartridges tailored to local feedwater quality—easily swappable and configurable for variable hardness, chlorine, or organic load
- No external softening required for most municipal supplies—reducing footprint, installation complexity, and lifecycle cost
- Full system control via intuitive touchscreen interface with password-protected user levels and audit-trail-capable event logging
- Modular design supports seamless integration into building-wide purified water distribution loops—including pump modules, secondary UV units, ASM (Air Sterile Membrane) vent filters, and loop-resident TOC/resistivity sensors
Sample Compatibility & Compliance
The Elix 20 is validated for compatibility with a broad range of feedwater sources across Europe and North America, including chlorinated and chloraminated municipal supplies. Its performance is certified under ISO 9001 and CE-marked per Directive 2014/30/EU (EMC) and 2014/35/EU (LVD). All critical water quality parameters comply with regulatory frameworks governing pharmaceutical and clinical laboratory operations: USP , EP 2.2.43, FDA 21 CFR Part 11 (when paired with compatible data management software), and GLP/GMP-aligned documentation packages. The system’s built-in calibration traceability, alarm thresholds, and automatic log generation support routine internal audits and third-party inspections.
Software & Data Management
While the Elix 20 operates autonomously via its embedded controller, optional connectivity modules enable integration with Millipore’s LabManager™ or third-party LIMS platforms via Ethernet or RS-485. All system events—including cartridge saturation alerts, pressure deviations, TOC excursions, and resistivity drift—are timestamped and stored locally for ≥12 months. Exportable CSV logs include operator ID, action type, parameter values, and environmental conditions (ambient temperature, inlet pressure). When configured with secure authentication and encrypted communication protocols, the system satisfies data integrity requirements outlined in Annex 11 (EU GMP) and ALCOA+ principles.
Applications
- Preparation of microbiological growth media and cell culture buffers
- Formulation of HPLC mobile phases and sample diluents
- Feedwater for Milli-Q® and Super-Q™ ultrapure water systems
- Routine laboratory equipment supply (autoclaves, glassware washers, clinical analyzers)
- Pharmaceutical manufacturing support—Purified Water grade per USP/EP
- Hydroponic and plant tissue culture applications requiring low ionic and organic background
- Synthesis of reagents and standards where trace metal contamination must remain below 0.1 ppb
FAQ
What feedwater specifications are recommended for optimal Elix 20 performance?
Municipal tap water with total dissolved solids (TDS) ≤ 500 ppm, free chlorine ≤ 3 ppm, and turbidity ≤ 1 NTU is suitable. Pre-treatment customization is available for higher-chlorine or hard-water sources.
Can the Elix 20 be connected to an existing building-wide distribution loop?
Yes—the system includes dedicated loop interface ports and supports pressure-controlled recirculation with integrated pump and ASM vent filtration.
Is TOC monitoring mandatory, or can it be disabled?
TOC monitoring is enabled by default and cannot be disabled; it is integral to system validation and compliance with USP and EP 2.2.44.
How often do pre-treatment cartridges require replacement?
Replacement frequency depends on feedwater quality and daily usage volume; typical service intervals range from 6–12 months, with real-time monitoring providing predictive alerts.
Does the Elix 20 meet FDA 21 CFR Part 11 requirements?
Out-of-the-box, the system provides electronic records and audit trails; full Part 11 compliance requires configuration with validated software, role-based access controls, and digital signature capability—available via optional LabManager™ integration.
