Organomation N-EVAP-12 Nitrogen Evaporator

Overview

The Organomation N-EVAP-12 Nitrogen Evaporator is a precision-engineered, water-bath-based sample concentration system designed for reproducible, oxygen-free solvent removal in analytical and preparative laboratories. It operates on the principle of controlled nitrogen gas displacement over heated liquid surfaces—accelerating solvent evaporation while minimizing thermal degradation, oxidation, or analyte loss. Unlike vacuum-based concentrators, the N-EVAP-12 maintains ambient pressure and provides gentle, uniform heating via a digitally regulated water bath, making it especially suitable for thermally labile compounds encountered in pharmaceutical QC, environmental residue analysis, and clinical biochemistry workflows. Its modular architecture supports method standardization across GLP- and GMP-regulated environments, and its design complies with fundamental safety and performance expectations outlined in ASTM D7622 (Standard Practice for Solvent Removal Using Nitrogen Evaporation) and ISO/IEC 17025–2017 clause 6.4.2 regarding equipment suitability for intended use.

Key Features

• Twelve-position stainless-steel sample block mounted on a stable, corrosion-resistant aluminum base with integrated water reservoir and digital PID temperature controller
• Water bath heating system delivering precise temperature control from ambient to 99 °C with ±1 °C uniformity across all positions
• Individual adjustable stainless-steel gas delivery needles with integrated needle valves—enabling independent flow regulation (0–10 L/min total, ~330 mL/min per channel) and real-time visual monitoring
• Front-access rotating sample holder allowing ergonomic, unobstructed access to all tubes without repositioning the instrument
• Gas pressure regulation system featuring dual-stage regulators: input range 30–150 psig, output range 0–30 psig—compatible with standard lab nitrogen supply lines
• Lab-grade construction: all wetted components—including gas manifolds, needle guides, and bath housing—are chemically resistant to common organic solvents (e.g., acetonitrile, methanol, chloroform, ethyl acetate)
• Optional dry-block heater module available for applications requiring rapid thermal ramping or solvent compatibility issues with water immersion

Sample Compatibility & Compliance

The N-EVAP-12 accommodates a broad range of standard laboratory vessels—including round-bottom test tubes (10–30 mm OD), conical centrifuge tubes, culture tubes, and small-volume glass vials—without adapter modification. Its open-platform geometry permits simultaneous processing of heterogeneous tube sizes within a single run. The system meets essential electrical safety requirements per UL 61010-1 and IEC 61010-1. While not certified as “21 CFR Part 11 compliant” out-of-the-box, its analog controls and mechanical gas regulation support full auditability when paired with external electronic loggers and SOP-controlled operation—making it suitable for FDA-registered facilities conducting method validation under USP Analytical Instrument Qualification protocols.

Software & Data Management

The N-EVAP-12 is a standalone, hardware-controlled instrument with no embedded microprocessor or software interface. Temperature setpoint and gas flow are adjusted manually via calibrated dials and analog gauges—ensuring operational simplicity, long-term reliability, and immunity to firmware obsolescence. For laboratories requiring traceable parameter recording, integration with external data acquisition systems (e.g., LabVIEW, Delta-T Loggers, or custom PLC interfaces) is supported through optional analog voltage outputs (0–5 VDC) for bath temperature and pressure transducer signals. All configuration settings, calibration records, and maintenance logs must be maintained per institutional GLP documentation standards.

Applications

• Pesticide residue analysis in food matrices (AOAC 2007.01, EN 15662)
• Pharmaceutical impurity profiling and stability-indicating assays (ICH Q2(R2))
• Environmental contaminant extraction workflows—including PAHs, PCBs, dioxins, and PFAS in water and soil extracts
• Clinical toxicology sample prep: steroid hormone quantification in serum/plasma (LC-MS/MS), urinary drug screening
• Natural product isolation: terpene, alkaloid, and flavonoid enrichment from plant extracts
• Forensic toxicology: blood alcohol and volatile compound concentration prior to GC-FID/GC-MS analysis

FAQ

Can the N-EVAP-12 be used with flammable solvents such as ether or hexane?

Yes—provided appropriate engineering controls (e.g., fume hood ventilation, explosion-proof nitrogen supply, grounded instrumentation) are in place. All gas pathways and structural materials are compatible with hydrocarbon solvents.
Is calibration certification included with shipment?

No factory-issued calibration certificate is provided; however, the unit ships with a NIST-traceable temperature verification report for the water bath sensor. Users are responsible for periodic verification per ISO/IEC 17025 Section 6.5.
What maintenance is required for long-term reliability?

Monthly descaling of the water bath (using 10% citric acid solution), biannual inspection of O-rings and needle valve seats, and annual replacement of the bath water level float switch are recommended.
Does Organomation offer IQ/OQ documentation packages?

Yes—customizable Installation Qualification (IQ) and Operational Qualification (OQ) protocol templates are available upon request for GxP-regulated laboratories.
Can I upgrade from water bath to dry block heating post-purchase?

Yes—the N-EVAP platform supports field retrofitting with the Organomation Dry-Block Heater Kit (Part #DBH-12), requiring only mechanical mounting and electrical connection.