RWD R510-22-10 Isoflurane Inhalation Anesthetic for Veterinary and Preclinical Research

Overview

RWD R510-22-10 Isoflurane is a high-purity, USP-grade inhalation anesthetic formulated specifically for controlled anesthesia in laboratory animals during surgical, imaging, and physiological research procedures. As a halogenated ether compound, isoflurane acts via reversible depression of central nervous system activity through modulation of GABA_A and NMDA receptors. Its pharmacokinetic profile—characterized by low blood:gas partition coefficient (1.4), rapid onset, and predictable recovery—enables precise titration of anesthetic depth using calibrated vaporizers. This makes it the preferred agent for longitudinal studies requiring repeated anesthesia sessions, such as functional MRI, electrophysiology, and chronic implantation surgeries in rodents, rabbits, and non-human primates. The R510-22-10 formulation complies with veterinary pharmaceutical standards outlined in the Chinese Veterinary Pharmacopoeia and meets the purity specifications required for GLP-compliant preclinical research environments.

Key Features

• High chemical purity (>99.9% isoflurane, certified by GC analysis) ensuring consistent anesthetic potency and minimal metabolic byproduct formation
• Stable vapor pressure (240 mmHg at 20 °C) compatible with standard precision vaporizers (e.g., Matrx, SomnoSuite, VetEquip)
• Rapid induction and emergence: typical time to loss of righting reflex < 90 s; spontaneous recovery within 2–3 minutes after discontinuation
• Low incidence of cardiorespiratory depression compared to older agents (e.g., halothane), supporting stable hemodynamics during prolonged procedures
• Supplied in amber glass bottles (100 mL each) with tamper-evident seals and lot-specific COA (Certificate of Analysis)
• Batch-tested for residual solvent content, heavy metals, and microbial contamination per ISO 11737-1

Sample Compatibility & Compliance

RWD Isoflurane is validated for use across common laboratory species including C57BL/6 and BALB/c mice, Sprague-Dawley and Wistar rats, New Zealand White rabbits, and domestic swine. It is not indicated for use in food-producing animals or companion animals outside institutional IACUC-approved protocols. Each production lot undergoes full quality release testing aligned with Chinese Veterinary Drug Administration (CVDA) requirements and conforms to international reference standards (EP 10.0, USP-NF 42). The product carries Guangdong Provincial Veterinary Drug Advertising Approval No. Yue Shouyao Guangshen (2025) 44030005. Packaging and labeling comply with ICH Q5C stability guidelines and support 24-month shelf life when stored unopened at 15–30 °C, protected from light and moisture.

Software & Data Management

While isoflurane itself is a consumable pharmaceutical agent, its administration is integrated into digital anesthesia workflows via compatible vaporizer control systems and animal monitoring platforms (e.g., Kent Scientific PhysioSuite, Nonin Animal Vital Signs Monitor). RWD provides batch traceability documentation—including manufacturing date, expiration date, COA, and sterility validation reports—for integration into electronic lab notebooks (ELN) and LIMS systems. All documentation supports audit readiness for AAALAC International accreditation, NIH OLAW compliance, and FDA GLP inspections (21 CFR Part 58), including full retention of raw analytical data and environmental monitoring logs.

Applications

• Neuroscience: craniotomy, stereotaxic surgery, in vivo calcium imaging, and optogenetic stimulation under stable plane III anesthesia
• Oncology: tumor resection, orthotopic implantation, and longitudinal bioluminescence imaging with minimal inter-session variability
• Cardiovascular research: echocardiography, Doppler flow measurement, and telemetry-based hemodynamic monitoring
• Immunology: splenectomy, lymph node harvesting, and adoptive T-cell transfer protocols requiring rapid postoperative recovery
• Toxicology: repeat-dose safety studies where consistent anesthetic depth minimizes stress-induced confounders (e.g., corticosterone elevation)

FAQ

Is RWD Isoflurane suitable for use in GLP-regulated toxicology studies?

Yes—each batch is manufactured under a validated quality management system compliant with GB/T 19001–2016 (ISO 9001:2015) and accompanied by full regulatory documentation for GLP study reporting.

What vaporizer types are compatible with R510-22-10?

The formulation is fully compatible with all isoflurane-specific precision vaporizers meeting ISO 8535-1:2020 performance criteria, including variable-bypass and electronic concentration-controlled units.

Does this product require special storage conditions beyond standard lab refrigeration?

No refrigeration is required; store upright at room temperature (15–30 °C) in original packaging, away from direct sunlight and oxidizing agents.

Can RWD Isoflurane be used in non-human primate models?

Yes—dosing protocols follow established NHP anesthetic guidelines (e.g., NRC Guide for Care and Use of Laboratory Animals, Chapter 2), with titration based on end-tidal concentration monitoring.

Is there a Certificate of Analysis available for each case shipment?

Yes—digital COA with GC chromatograms, impurity profiles, and microbiological test results is provided with every order via secure download link.