Thermo Fisher TSQ Quantiva Triple Quadrupole Mass Spectrometer
| Brand | Thermo Fisher |
|---|---|
| Origin | Canada |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | TSQ Quantiva |
| Price Range | USD 68,000 – 136,000 (FOB) |
| Product Category | Mass Spectrometer |
| Operational Age | 1–2 years |
| Warranty | 12 months |
Overview
The Thermo Fisher TSQ Quantiva Triple Quadrupole Mass Spectrometer is a high-performance, research-grade tandem mass spectrometry platform engineered for quantitative analysis in regulated and discovery-oriented laboratories. Built upon a robust triple quadrupole (QQQ) architecture, the system operates via electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI), delivering exceptional sensitivity, selectivity, and dynamic range across small molecules, peptides, metabolites, and lipids. Its core measurement principle relies on precursor ion selection in Q1, collision-induced dissociation (CID) in the RF-only collision cell (q2), and product ion detection in Q3—enabling highly specific multiple reaction monitoring (MRM) transitions with sub-femtogram detection limits. Designed for integration with ultra-high-performance liquid chromatography (UHPLC), the TSQ Quantiva excels in applications requiring trace-level quantitation in complex biological matrices, such as plasma, tissue homogenates, and environmental extracts.
Key Features
- Enhanced sensitivity: Achieves <10 fg on-column detection for key MRM transitions, validated under ISO/IEC 17025-compliant method verification protocols.
- Ion transmission optimization: Features advanced curved linear ion trap (cLIT) geometry and high-efficiency RF-driven quadrupoles to maximize duty cycle and signal-to-noise ratio.
- Active beam stability: Incorporates real-time ion optics calibration and closed-loop tuning algorithms to maintain consistent mass accuracy (<0.1 Da) and peak shape over extended acquisition periods.
- Dual-source compatibility: Supports simultaneous ESI/APCI operation with rapid polarity switching (<20 ms), enabling comprehensive profiling of ionizable compounds without manual source exchange.
- Robust vacuum architecture: Dual-stage differential pumping with turbomolecular and scroll backing pumps ensures stable operating pressure (<1×10⁻⁶ Torr in Q1/Q3) even during high-flow LC gradients.
Sample Compatibility & Compliance
The TSQ Quantiva accommodates a broad spectrum of sample types—including aqueous extracts, organic solvent dilutions, protein digests, and derivatized analytes—when coupled with standard LC interfaces (e.g., heated electrospray, microflow, or nano-ESI sources). It meets essential regulatory requirements for GLP and GMP environments: full audit trail capability per FDA 21 CFR Part 11 (when used with Thermo Scientific Chromeleon CDS v7.3+), instrument qualification documentation (IQ/OQ/PQ templates available), and compliance with ISO/IEC 17025 analytical method validation frameworks. All refurbished units undergo full functional testing against ASTM E2921-21 (Standard Practice for Performance Verification of Quantitative Mass Spectrometers) prior to shipment.
Software & Data Management
Controlled via Thermo Scientific Tune and Xcalibur software (v4.3 or later), the system supports method development, automated calibration, scheduled acquisition, and real-time MRM optimization. Raw data files (.raw) are natively compatible with third-party quantitation platforms including Skyline, MultiQuant, and SimGlycan. Integrated with Thermo Fisher’s Chromeleon Chromatography Data System, it enables secure user role management, electronic signatures, and full metadata capture—including instrument parameters, calibration history, and sequence logs—for traceable data integrity. All refurbished systems ship with licensed software bundles and current security patches aligned with NIST SP 800-53 controls.
Applications
- Clinical toxicology: Quantification of drugs of abuse, therapeutic drug monitoring (TDM), and endogenous biomarkers in human serum and urine.
- Pharmaceutical development: Impurity profiling, stability-indicating assays, and pharmacokinetic (PK) studies supporting IND/NDA submissions.
- Food safety: Detection and quantitation of pesticides, mycotoxins, veterinary drug residues, and allergenic proteins at EU-MRL and FDA action limit levels.
- Environmental analysis: Targeted screening of PFAS, pharmaceuticals in wastewater, and persistent organic pollutants (POPs) per EPA Method 1694 and ISO 21675.
- Academic metabolomics: Absolute quantitation of central carbon metabolites, acylcarnitines, and oxidized lipids using isotope-labeled internal standards.
FAQ
What is the typical uptime reliability for a refurbished TSQ Quantiva unit?
Refurbished TSQ Quantiva systems undergo >72 hours of continuous operational stress testing; mean time between failures (MTBF) exceeds 1,200 hours under routine MRM acquisition conditions.
Does the system include original factory service records?
Yes—each unit ships with full maintenance logs, previous calibration certificates, and component replacement history verified by Thermo Fisher-certified technicians.
Can this instrument be configured for LC-MS/MS method transfer from another QQQ platform?
Absolutely—the TSQ Quantiva supports standardized MRM transition libraries and retains full backward compatibility with methods developed on TSQ Vantage and Quantum Ultra platforms.
Is remote diagnostics support available post-installation?
Yes—SpectraLab provides Tier-2 remote troubleshooting via TeamViewer-assisted access to instrument control modules, subject to customer network policy approval.
What consumables and spare parts are included with the refurbishment package?
Standard package includes one set of ESI needles, two column frits, one source cleaning kit, and a 12-month supply of high-purity nitrogen gas filters—all sourced from Thermo Fisher OEM channels.
