Aliben UHPLC-TQMS G1 Triple Quadrupole Liquid Chromatography Mass Spectrometer

Overview

The Aliben UHPLC-TQMS G1 is a fully integrated triple quadrupole liquid chromatography mass spectrometry system engineered for high-sensitivity, quantitative trace analysis in regulated and research-intensive environments. Built upon electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) source technologies, the instrument employs a robust tandem mass spectrometry architecture—comprising Q1 (mass-selective first quadrupole), Q2 (segmented collision cell operating in RF-only mode), and Q3 (mass-analyzing third quadrupole)—to deliver selective reaction monitoring (SRM) and multiple reaction monitoring (MRM) capabilities with high duty cycle efficiency. Its design emphasizes analytical reproducibility, long-term signal stability, and resistance to matrix-induced suppression—critical for multi-residue analysis in complex biological, environmental, and food matrices. All core subassemblies—including the ion source, multi-stage ion optics, pre-quadrupole lens assembly, segmented RF-only collision cell, off-axis high-gain electron multiplier detector, and precision quadrupole RF/DC power supply—are developed and manufactured in-house by Aliben, ensuring full supply chain control and compliance-ready traceability.

Key Features

• Fully国产ized (domestically engineered and produced) triple quadrupole platform meeting ISO/IEC 17025-aligned manufacturing controls
• High-stability dual-mode ion source supporting ESI+/ESI− and APCI+/APCI− with active desolvation gas optimization and temperature-controlled interface
• Multi-stage ion transmission optics minimizing ion loss across wide m/z ranges and enhancing signal-to-noise ratio in low-abundance analyte detection
• Segmented collision cell enabling efficient fragmentation at variable collision energies with minimal cross-talk and improved MRM peak shape fidelity
• Off-axis electron multiplier detector providing extended dynamic range (>6 orders) and reduced noise floor for sub-pg/mL quantification limits
• Modular UHPLC subsystem featuring 1300 bar maximum backpressure, <5 µL system dwell volume, and <0.2% RSD gradient precision

Sample Compatibility & Compliance

The UHPLC-TQMS G1 supports direct injection of extracts from diverse sample types—including plasma, urine, tissue homogenates, soil leachates, wastewater, plant extracts, and food digests—without requiring extensive pre-purification when coupled with appropriate solid-phase extraction (SPE) or QuEChERS workflows. Its hardware and firmware architecture comply with fundamental requirements for GLP and GMP environments: audit trail-enabled software logging, user role-based access control, electronic signature support per FDA 21 CFR Part 11, and method versioning with timestamped metadata. Instrument qualification documentation—including IQ/OQ protocols aligned with ASTM E2656 and USP <1058>—is provided to facilitate laboratory validation under ISO/IEC 17025 or CLIA frameworks.

Software & Data Management

Aliben’s proprietary LC-MS workstation integrates instrument control, data acquisition, processing, and reporting into a single unified environment. The interface follows ICH M10-compliant data handling principles, supporting raw data archiving in open-format mzML alongside proprietary binary formats. Key modules include: AutoTune for automated mass calibration and resolution optimization; AutoMethodBuilder for intelligent SRM transition selection based on compound database libraries; QuantStudio for batch-processed calibration curve fitting (linear, quadratic, weighted), outlier detection, and QC flagging per ISO 11843-7; and AuditLog Manager for immutable recording of all parameter changes, sequence edits, and report generation events. All software components undergo annual cybersecurity patching and are validated for Windows 10/11 LTSB editions in network-isolated lab environments.

Applications

The system is routinely deployed in laboratories performing targeted quantitative assays across six principal domains: (1) Food safety—pesticide residue screening (e.g., EU SANTE/11312/2021), veterinary drug monitoring (β-agonists, sulfonamides), and mycotoxin quantification (aflatoxins, ochratoxin A); (2) Environmental analysis—persistent organic pollutants (POPs), pharmaceuticals and personal care products (PPCPs), and per- and polyfluoroalkyl substances (PFAS) in water and sediment; (3) Clinical toxicology—therapeutic drug monitoring (TDM), neonatal screening metabolites, and forensic toxicant identification; (4) Public security—illicit drug profiling (fentanyl analogues, synthetic cannabinoids), explosives residue confirmation, and chemical warfare agent degradation product detection; (5) Biopharmaceutical development—peptide mapping, ADC payload quantification, and host-cell protein impurity assessment; (6) Academic and government research—metabolomics pathway validation, exposome biomarker discovery, and method transfer studies between legacy and next-generation platforms.

FAQ

Is the UHPLC-TQMS G1 compliant with FDA 21 CFR Part 11?
Yes—the workstation includes full electronic signature functionality, audit trail generation, and secure user authentication as defined in Part 11 Subpart B.
What ionization modes does the system support?
Dual ESI and APCI sources are standard, each configurable for positive/negative polarity switching within a single run.
Can the system be integrated into existing LIMS environments?
Yes—via standardized ASTM E1384-compliant ASCII output and optional OPC UA server module for real-time instrument status telemetry.
Does Aliben provide application notes and method packages?
Yes—validated methods for >200 analytes across food, clinical, and environmental categories are available upon request, including SOPs, calibration standards, and QC acceptance criteria.
What service and support options are offered outside mainland China?
Aliben partners with certified regional service providers in Southeast Asia, the Middle East, and Latin America; remote diagnostics and annual preventive maintenance contracts are available globally.