Thermo Fisher TSQ Quantis Plus Triple Quadrupole Liquid Chromatography Mass Spectrometer (Domestically Manufactured in Shanghai)

Overview

The Thermo Fisher TSQ Quantis Plus Triple Quadrupole Liquid Chromatography Mass Spectrometer (LC-MS/MS) is a high-performance, domestically manufactured mass spectrometry platform engineered for precision targeted quantitation in regulated and research laboratories. Built upon the proven triple quadrupole architecture, it employs collision-induced dissociation (CID) in the central q2 collision cell to generate structurally informative product ions from selected precursor ions in Q1, enabling highly selective and sensitive multiple reaction monitoring (MRM) detection. This instrument is specifically optimized for quantitative bioanalysis, environmental contaminant screening, food safety testing, clinical toxicology, and pharmaceutical impurity profiling—applications demanding robustness, reproducibility, and compliance with international regulatory expectations.

Key Features

• High-speed MRM acquisition capability supporting >10,000 transitions per second, enabling comprehensive multi-analyte quantitation within narrow chromatographic peaks and facilitating large-scale, high-throughput screening workflows.
• Enhanced instrument robustness through thermally stable ion optics, vacuum system redundancy, and intelligent source diagnostics—designed to maximize uptime and minimize maintenance interventions in 24/7 laboratory environments.
• Six-decade linear dynamic range (1–10⁶) validated across diverse compound classes, ensuring accurate quantitation of low-abundance analytes in complex matrices without signal saturation or dilution requirements.
• Intuitive, workflow-driven software interface with guided method setup, real-time spectral feedback, and automated calibration verification—reducing operator dependency and supporting consistent data quality across junior and senior analysts.
• Backward-compatible method transfer from existing TSQ Quantis systems, preserving historical method libraries and accelerating instrument adoption without revalidation overhead.

Sample Compatibility & Compliance

The TSQ Quantis Plus interfaces seamlessly with standard UHPLC, HPLC, and HPIC systems via industry-standard ESI and APCI sources, accommodating a broad polarity range—from small polar metabolites to moderately lipophilic pharmaceuticals. It supports both positive and negative ionization modes with rapid polarity switching (<20 ms), critical for untargeted screening applications. The system meets essential design and operational criteria aligned with ISO/IEC 17025:2017 for testing laboratories and supports audit-ready configurations compliant with FDA 21 CFR Part 11, including electronic signatures, secure user access control, and full audit trail logging for all method, acquisition, and processing events. Routine performance verification follows Thermo Fisher’s standardized QC protocols, referencing NIST-traceable standards and internal lock-mass correction where applicable.

Software & Data Management

Controlled by Thermo Scientific TraceFinder™ Software (v5.2 or later), the TSQ Quantis Plus delivers integrated acquisition, processing, and reporting capabilities tailored for regulated quantitative workflows. TraceFinder includes built-in compliance features such as customizable report templates, automatic peak integration validation, batch-level QC flagging, and raw data integrity assurance via SHA-256 checksum generation. All processed results are stored in a relational database structure supporting SQL-based querying, version-controlled method archiving, and export to LIMS-compatible formats (e.g., CSV, XML, AnIML). Audit trails record timestamped actions—including parameter modifications, calibration updates, and result approvals—with immutable storage and role-based viewing permissions.

Applications

• Bioanalytical quantitation of drugs and metabolites in plasma, serum, and tissue homogenates per FDA Bioanalytical Method Validation Guidance.
• Residue analysis of pesticides, veterinary drugs, and mycotoxins in food commodities according to EU SANTE/2023/2023 and AOAC Official Methods®.
• Environmental monitoring of PFAS, pharmaceuticals, and endocrine disruptors in wastewater and surface water per EPA Method 1694 and ISO 21675:2019.
• Clinical toxicology screening for opioids, benzodiazepines, and stimulants in urine and blood using accredited MRM panels.
• Impurity identification and quantitation in drug substance and product per ICH Q3B(R3), supported by optional add-on libraries and spectral matching tools.

FAQ

Is the TSQ Quantis Plus manufactured entirely in Shanghai?
Yes—the instrument assembly, final system integration, and factory acceptance testing are performed at Thermo Fisher’s Shanghai manufacturing facility, under the same quality management system (ISO 9001-certified) applied to global production sites.
Does it support GLP/GMP-compliant data handling?
Yes—when configured with TraceFinder in compliance mode and deployed on validated IT infrastructure, the system satisfies core GLP (OECD Principles) and GMP (ICH Q5E, Annex 11) data integrity requirements, including ALCOA+ principles.
Can it be upgraded to support high-resolution MS/MS functions?
No—the TSQ Quantis Plus is a dedicated triple quadrupole platform; high-resolution capabilities require migration to the Orbitrap-based Fusion Lumos or Exploris series.
What level of technical support is available outside North America?
Local application scientists and certified field service engineers are stationed across Greater China, with 24/7 remote diagnostics and on-site response SLAs defined per service contract tier.
Is method validation documentation provided?
Thermo Fisher supplies instrument qualification protocols (IQ/OQ/PQ), system suitability test procedures, and traceable calibration reports—customizable to align with individual laboratory SOPs and regulatory submission needs.