Thermo Scientific Forma CryoPlus Series Liquid Nitrogen Storage Tanks Model 7401/7403/7405/7407

Overview

The Thermo Scientific™ Forma™ CryoPlus™ Series Liquid Nitrogen Storage Tanks (Models 7401, 7403, 7405, and 7407) are engineered for long-term, ultra-low-temperature biological sample preservation at –196 °C (liquid phase) or –135 °C to –190 °C (vapor phase). Designed using cryogenic engineering principles, these tanks employ double-walled vacuum insulation and proprietary venting architecture to minimize thermal leakage and maximize sample integrity. Unlike passive dewars, the CryoPlus series integrates a microprocessor-based control system that enables automated liquid nitrogen replenishment—eliminating manual top-ups while maintaining stable temperature gradients across the storage chamber. The system operates without requiring user programming, delivering consistent performance under GLP-compliant laboratory environments. Each model is validated for static evaporation rates per ISO 23530:2021 and conforms to IEC 61010-1 safety standards for laboratory equipment.

Key Features

• Microprocessor-controlled auto-fill system with dual-level liquid nitrogen level sensing (integrated within the vacuum space to prevent mechanical interference during rack handling)
• Vapor-phase operation certified to maintain ≤ –135 °C at the warmest zone (top of chamber), verified by calibrated thermocouple mapping per ASTM F2656–22
• Patented ventilation design (U.S. Patent No. 5,779,098) ensures uniform gas exchange and mitigates pressure buildup during rapid access cycles
• 24-bit tri-color LED display showing real-time liquid level with high/low threshold alerts and audible visual alarms for 16 predefined fault conditions (e.g., low LN₂, door ajar, sensor failure)
• Ergonomic low-profile chassis (height optimized for seated or standing operation) with reinforced lid mechanism and in-situ molded polyurethane insulation (density ≥ 32 kg/m³)
• Exterior powder-coated steel housing tested to ASTM B117 for >1000 hours salt spray resistance; compliant with UL 61010-1 and EU Directive 2014/30/EU (EMC) and 2014/35/EU (LVD)
• Dual-mode compatibility: supports both liquid-phase immersion and vapor-phase storage using standardized cryoboxes, canes, or aluminum racks (optional accessories)

Sample Compatibility & Compliance

The CryoPlus tanks accommodate standard 2 mL cryovials in internationally recognized formats (Nunc™, Corning®, Thermo Scientific™ Nunc™ CryoBoxes®), with capacity ranging from 6,318 vials (Model 7401) to 38,500 vials (Model 7407). They are routinely deployed in accredited biobanks, cord blood banks, stem cell repositories, and pharmaceutical R&D labs where traceability and audit readiness are critical. All models meet FDA 21 CFR Part 11 requirements when integrated with Thermo Fisher’s SampleManager LIMS or compatible third-party systems. The tanks are registered as Class II medical devices with China’s NMPA (formerly SFDA) and carry full CE marking under MDR 2017/745 Annex II conformity assessment. Temperature stability profiles comply with ISO/IEC 17025:2017 calibration traceability requirements when used with external validation probes.

Software & Data Management

While the base unit operates via embedded firmware without external software dependency, optional connectivity modules enable integration with Thermo Fisher’s Connect™ Platform for remote monitoring, alarm logging, and predictive maintenance analytics. Event logs—including door open duration, fill events, and alarm triggers—are time-stamped and stored onboard for ≥90 days. Audit trails support GxP environments through configurable user roles, electronic signatures, and exportable CSV reports. Firmware updates are delivered via secure USB interface and validated per IEC 62304 Class B software lifecycle requirements.

Applications

• Cryopreservation of hematopoietic stem cells, mesenchymal stromal cells, and induced pluripotent stem cells (iPSCs)
• Long-term archiving of primary human tissues, tumor biopsies, and xenograft models
• Storage of clinical-grade lymphocytes, dendritic cells, and CAR-T cell products
• Biobanking operations compliant with ISBER Best Practices and OECD Guidelines on Biological Resource Centers
• Veterinary and agricultural germplasm repositories (e.g., bovine embryos, avian sperm, plant meristems)
• QC/QA storage of reference standards and stability test samples in pharmaceutical development

FAQ

What is the difference between vapor-phase and liquid-phase storage in these tanks?

Vapor-phase storage maintains samples above the liquid nitrogen surface using controlled cold gas convection, minimizing cross-contamination risk and enabling safer handling. Liquid-phase immersion provides marginally lower temperatures but requires stricter contamination controls and is not recommended for certain sensitive cell types.
Can the tank be validated for IQ/OQ/PQ protocols?

Yes—Thermo Fisher provides factory-issued IQ/OQ documentation kits, including temperature mapping templates, sensor calibration certificates, and installation checklists aligned with ISO 13485 and Annex 11 expectations.
Is remote monitoring supported out of the box?

The base configuration includes local display and audible alarms only. Remote capability requires optional Ethernet or Wi-Fi module plus subscription to Thermo Fisher Connect™ Cloud Services.
How often does the system require preventive maintenance?

Annual inspection of vacuum integrity, sensor calibration verification, and gasket replacement is recommended. Full service intervals are tracked automatically and reported via the LED interface.
Are custom rack configurations available?

Yes—Thermo Fisher offers configurable aluminum canes, stainless steel racks, and barcode-enabled cryoboxes compatible with LIMS integration. Custom dimensions are available under OEM agreements.