Hitachi Chromaster High-Performance Liquid Chromatography System
| Brand | Hitachi |
|---|---|
| Origin | Canada |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | Chromaster |
| Price Range | USD 13,500 – 40,500 (FOB) |
| Product Category | Chromatography |
| Operational Age | 4–5 Years |
| Warranty | 6 Months Limited |
Overview
The Hitachi Chromaster High-Performance Liquid Chromatography (HPLC) System is a modular, research-grade analytical platform engineered for precision, robustness, and long-term operational stability. Designed around Hitachi’s proprietary dual-piston parallel-flow pump architecture, the system delivers exceptional gradient accuracy (<0.1% RSD), low pulsation, and high-pressure tolerance up to 60 MPa (8700 psi). Its core measurement principle relies on liquid-phase separation under controlled mobile phase composition, flow rate, temperature, and detection wavelength—enabling quantitative and qualitative analysis of small molecules, pharmaceutical actives, natural products, and synthetic intermediates. As a pre-owned but fully refurbished instrument, each unit undergoes comprehensive functional validation—including baseline noise assessment, retention time reproducibility (RSD < 0.15%), peak area precision (RSD < 0.5%), and detector linearity across UV-VIS range (190–800 nm)—in accordance with ISO/IEC 17025-aligned internal protocols.
Key Features
- Modular configuration including CM-5110 quaternary solvent delivery system with integrated degasser and real-time pressure monitoring
- CM-5210 autosampler featuring 100-position vial capacity, programmable injection volume (0.1–100 µL), and needle wash station with dual solvent capability
- CM-5310 column oven supporting temperature control from ambient +5°C to 85°C (±0.1°C stability) with dual-column switching capability
- CM-5420 UV-VIS photodiode array detector offering 1024-pixel linear array, spectral acquisition at 100 Hz, and simultaneous multi-wavelength quantitation
- Integrated GUI controller with intuitive touch interface, method storage for ≥500 methods, and built-in audit trail logging
- All modules are factory-calibrated and verified for compliance with ASTM E2621 (Standard Guide for HPLC System Suitability) and USP <621> chromatographic system suitability requirements
Sample Compatibility & Compliance
The Chromaster platform supports reversed-phase, normal-phase, ion-exchange, and size-exclusion chromatography using standard 2.1–4.6 mm ID columns (up to 250 mm length). It accommodates aqueous, organic, and mixed mobile phases—including TFA, formic acid, ammonium acetate, and phosphate buffers—within pH 1.5–12.0 range. Each refurbished system includes full documentation of calibration certificates, preventive maintenance logs, and post-refurbishment performance qualification (PQ) reports. The instrument meets essential regulatory expectations for GLP and GMP environments: electronic records comply with FDA 21 CFR Part 11 principles (user authentication, electronic signatures, and immutable audit trails), while data integrity controls align with ALCOA+ (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available).
Software & Data Management
Operated via Hitachi’s native Chromaster Navigator software (v2.5 or later), the system supports method development, sequence scheduling, real-time chromatogram visualization, peak integration using multiple algorithms (tangent skim, valley-to-valley, exponential skim), and automated system suitability testing. Raw data files (.chm) are stored in vendor-neutral format compatible with third-party CDS platforms (e.g., OpenLab CDS, Chromeleon). All units include licensed software media, activation keys, and installation support. Data backup and export functions support CSV, PDF, and XML formats—ensuring seamless integration into LIMS and ELN workflows. Audit trail review functionality allows timestamped tracking of all user actions, parameter changes, and report generations.
Applications
- Pharmaceutical QC/QA: Assay, related substances, dissolution testing per ICH Q2(R2) guidelines
- Academic research: Metabolite profiling, polymer characterization, chiral separations using dedicated columns
- Food & beverage safety: Pesticide residue screening, mycotoxin quantification, vitamin analysis
- Environmental testing: PAHs, phenols, and endocrine disruptors in water and soil extracts
- Chemical manufacturing: Reaction monitoring, purity assessment, and stability-indicating method validation
FAQ
Is this a factory-refurbished unit or dealer-refurbished?
All Hitachi Chromaster systems supplied by SpectraLab Scientific are professionally refurbished by certified Hitachi service partners in North America, including full mechanical inspection, fluidic path replacement, optical alignment verification, and firmware update to latest stable release.
What documentation accompanies the instrument?
Each shipment includes a Certificate of Refurbishment, PQ report, calibration summary, maintenance history, software license certificate, and a signed warranty agreement.
Can the system be configured for GMP-compliant operation?
Yes—optional 21 CFR Part 11 compliance package available upon request, including role-based access control setup, electronic signature configuration, and IQ/OQ protocol templates.
Do you provide installation and on-site training?
Remote commissioning is included; on-site installation and operator training are available as billable services with global coverage through our network of certified field engineers.
Are spare parts and consumables available post-purchase?
SpectraLab maintains an inventory of critical spares (pump seals, lamp assemblies, flow cells) and negotiates bulk pricing for columns, filters, and solvents through authorized Hitachi distribution channels.
