Organomation N-EVAP Series Water-Bath Nitrogen Evaporator

Overview

The Organomation N-EVAP Series is a precision-engineered water-bath nitrogen evaporator designed for controlled, gentle concentration of volatile solvents in analytical sample preparation workflows. Utilizing the principle of inert gas-assisted surface evaporation—where dry, filtered nitrogen is directed tangentially across the liquid meniscus of heated samples—the system accelerates solvent removal while minimizing analyte degradation, oxidation, and cross-contamination. Unlike dry-block or infrared-based concentrators, the N-EVAP’s thermostatically regulated water bath ensures uniform, low-gradient heating (0–80 °C), critical for thermolabile compounds encountered in pharmaceutical QC, clinical toxicology, environmental residue analysis, and metabolomics. Its modular architecture supports both 12-position and 24-position configurations, enabling scalable throughput without compromising temperature stability or gas flow reproducibility.

Key Features

• Stainless-steel water bath with PID-controlled digital thermostat, delivering ±2 °C temperature uniformity across all sample wells
• Individually adjustable, stainless-steel gas delivery needles with integrated needle valves and calibrated flow meters (0–10 L/min total; ~330 mL/min per sample typical)
• Rotatable sample support arm for unobstructed front-access loading and real-time visual monitoring of evaporation progress
• Chemically inert construction: all wetted and structural components rated for continuous exposure to common organic solvents (e.g., acetonitrile, methanol, chloroform, ethyl acetate) and optional acid-resistant coating for HCl/HF-containing matrices
• Modular design accommodates tubes (up to 29 mm OD), centrifuge vials, conical flasks, and scintillation vials without adapter kits
• No external compressor required—operates efficiently with standard lab-grade nitrogen supply (≥99.5% purity, 30–60 psi inlet pressure)

Sample Compatibility & Compliance

The N-EVAP Series is validated for use with a broad spectrum of sample containers and matrices encountered in regulated environments. It supports direct integration into workflows compliant with USP , ICH Q2(R2), and ASTM D7097–18 for residual solvent analysis. The system’s consistent thermal profile and low gas consumption facilitate adherence to GLP and GMP documentation requirements—including traceable temperature logs and operator-intervention records. All models are CE-marked and meet IEC 61010-1 safety standards for laboratory electrical equipment. Optional data logging modules support 21 CFR Part 11–compliant audit trails when paired with validated LIMS or ELN platforms.

Software & Data Management

While the base N-EVAP operates via intuitive front-panel controls (digital setpoint display, overtemperature cutoff, auto-shutdown timer), optional accessories enable enhanced traceability. The N-EVAP Connect module provides RS-232/USB output for real-time temperature and gas flow telemetry, compatible with third-party SCADA systems or custom Python/Matlab acquisition scripts. For regulated labs, the Organomation DataBridge firmware enables CSV export of time-stamped temperature history, user ID tagging, and event logging (e.g., lid open/close, setpoint change)—all structured to align with ALCOA+ data integrity principles.

Applications

• Pre-concentration of extracts prior to GC-MS, LC-MS/MS, or HPLC analysis in environmental testing (e.g., EPA Methods 508.1, 8081B)
• High-throughput cleanup of plasma, urine, and tissue homogenates in clinical pharmacokinetic studies
• Final solvent exchange and volume adjustment in oligonucleotide and peptide synthesis workflows
• Residual solvent removal from active pharmaceutical ingredients (APIs) per ICH Q3C guidelines
• Standardized evaporation of calibration standards and QC reference materials in ISO/IEC 17025-accredited laboratories

FAQ

What is the maximum recommended operating temperature for the water bath?
The N-EVAP Series is rated for continuous operation up to 80 °C. Exceeding this limit may compromise seal integrity and accelerate solvent boil-off beyond controlled evaporation kinetics.
Can ambient air be used instead of nitrogen?
Yes—though nitrogen is strongly recommended for oxygen-sensitive analytes; compressed air requires inline hydrocarbon and moisture filtration to prevent contamination.
Is calibration certification included with shipment?
Each unit ships with a factory-verified temperature calibration report (NIST-traceable probe). Optional IQ/OQ documentation packages are available upon request for regulated installations.
How is solvent recovery achieved at ~98% efficiency?
Via integrated condensate reflux design: vaporized solvent contacts cooled upper chamber surfaces and recondenses into a collection trough, minimizing atmospheric release and enabling safe recovery.
Are replacement parts (e.g., needles, O-rings, bath liners) available separately?
Yes—Organomation maintains full spare parts inventory with documented shelf-life and compatibility specifications for all N-EVAP generations (v1–v4).