HPM MZR-4622 Low-Pressure Micro-Dosing Peristaltic Pump

Overview

The HPM MZR-4622 Low-Pressure Micro-Dosing Peristaltic Pump is a precision-engineered fluid handling solution designed for integration into analytical instrumentation, laboratory automation platforms, and diagnostic systems requiring highly reproducible, low-shear, pulse-minimized micro-volume delivery. Unlike conventional peristaltic pumps relying on elastomeric tubing compression, the MZR-4622 employs a patented rotary micro annular gear displacement principle—enabling true positive displacement with minimal flow pulsation (<1% CV), negligible shear stress on sensitive samples (e.g., proteins, cells, or nanoparticles), and exceptional volumetric accuracy across its full operational range. Its compact cylindrical form factor (Ø16 mm × 88 mm) facilitates OEM integration into space-constrained instruments such as HPLC autosamplers, fuel cell test rigs, microfluidic assay workstations, and in vitro diagnostic (IVD) analyzers. The pump operates within a differential pressure window of 0–5 bar and supports inlet pressures up to 1 bar—making it ideal for low-backpressure applications involving aqueous buffers, organic solvents (methanol, acetonitrile), oils, lubricants, and low-viscosity calibration standards (0.3–100 mPa·s, extendable to 1,000 mPa·s under optimized conditions).

Key Features

• Micro-Annular Gear Displacement Mechanism: Delivers deterministic, non-pulsating flow without reliance on flexible tubing—eliminating tube fatigue, swelling, or chemical incompatibility issues common in traditional peristaltic designs.
• Ultra-High Dosing Precision: Achieves coefficient of variation (CV) <1% across the entire flow range (1.2–72 mL/min), with minimum controllable dose volume of 2 µL and resolution down to 0.012 mL/min (dependent on controller configuration).
• Chemically Resistant Wetted Path: Fluid-contact components include AISI 316L stainless steel, technical ceramic (Al₂O₃ or ZrO₂), tungsten carbide, nickel-based alloys, and epoxy-coated surfaces—ensuring compatibility with aggressive solvents, mild acids/bases, and biocompatible media.
• Low-Shear & Biocompatible Operation: Shear rates remain below 10⁴ s⁻¹ even at maximum speed, preserving integrity of labile biomolecules, liposomes, and cellular suspensions during transfer.
• Compact & Lightweight Design: Cylindrical geometry (Ø16 mm × 88 mm) and mass of ~100 g enable seamless integration into portable analyzers, point-of-care devices, and multi-axis robotic liquid handlers.
• Digital Position Feedback: Integrated Hall-effect magnetic encoder (32 pulses per revolution) enables closed-loop speed control, real-time RPM monitoring, and traceable dosing event logging—critical for GLP/GMP-compliant workflows.

Sample Compatibility & Compliance

The MZR-4622 is validated for use with low-to-moderate viscosity liquids (0.3–100 mPa·s nominal; up to 1,000 mPa·s with reduced speed and pressure margins), including deionized water, saline solutions, methanol, ethanol, isopropanol, hexane, silicone oils, and synthetic lubricants. Its wetted material set complies with USP Class VI and ISO 10993-5 cytotoxicity requirements when configured with FPM (FKM) or FFPM seals. While not intrinsically rated for hazardous area use, the pump meets EN 61000-6-3 (EMC emission) and EN 61000-6-2 (immunity) standards. It supports audit-ready operation in regulated environments when paired with a compliant motion controller enabling 21 CFR Part 11–compliant electronic records and signatures (e.g., via timestamped encoder data logs and user-access-controlled parameter sets).

Software & Data Management

The MZR-4622 interfaces via a standardized 10-pin connector supporting analog voltage (0–10 V) speed control, digital direction input, and encoder feedback output. For advanced integration, optional RS-485 or CANopen communication modules enable bidirectional command/response protocols—including real-time RPM reporting, fault status flags (overcurrent, stall, thermal limit), and programmable ramp profiles. When deployed in automated systems, its encoder data can be synchronized with chromatographic detectors or spectrophotometers to correlate dispense timing with analytical readouts. Data export formats (CSV, HDF5) support traceability in LIMS and ELN platforms, fulfilling ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available).

Applications

• Automated sample introduction in HPLC, IC, and CE systems requiring stable baseline flow and minimal carryover.
• Fuel cell stack testing—precise metering of humidified reactant gases or electrolyte solutions under controlled stoichiometry.
• Microfluidic organ-on-chip platforms demanding sub-microliter bolus delivery with temporal fidelity.
• In vitro diagnostic reagent dispensing in clinical chemistry and immunoassay analyzers—meeting IVD Regulation (EU 2017/746) fluid path consistency requirements.
• Calibration standard preparation in metrology labs where gravimetric verification of delivered volume is required (traceable to NIST SRMs).
• Environmental monitoring systems for continuous low-flow sampling of groundwater or surface water matrices.

FAQ

Is the MZR-4622 suitable for sterile or single-use applications?
No—the pump is designed for reusable, cleanable fluid paths. Sterile operation requires external sterilization of the fluid path (e.g., autoclaving compatible manifolds) or integration with disposable cartridge-based modules.
Can it handle viscous polymer solutions above 100 mPa·s?
Yes—with derated speed (≤3000 rpm) and reduced differential pressure (<2 bar), viscosities up to 1,000 mPa·s are feasible; however, precision may degrade beyond ±2% CV without recalibration.
What controller options are available for closed-loop dosing?
HPM offers the MC-4622 digital motion controller with PID tuning, encoder-based position tracking, and USB/RS-485 connectivity—fully programmable via LabVIEW, Python, or Modbus TCP.
Does the pump require periodic maintenance?
The ceramic gear train and graphite-reinforced PTFE shaft seal are engineered for >10,000 hours MTBF under continuous operation; no scheduled lubrication or wear-part replacement is required within specification limits.
Is explosion-proof certification available?
Not natively—but ATEX/IECEx-certified enclosures and barrier-rated signal conditioning modules can be supplied by authorized system integrators upon request.