RWD 68069 MRI-Compatible Mouse Head Holder (Customizable)
| Brand | RWD |
|---|---|
| Origin | Shenzhen, China |
| Manufacturer Type | OEM/ODM Manufacturer |
| Region of Origin | Domestic (China) |
| Model | 68069 |
| Pricing | Upon Request |
| Vertical Adjustment Range | −20 mm to +10 mm (30 mm total, 0.1 mm resolution) |
| Horizontal (Anterior–Posterior) Travel | 45 mm |
| Ear Bar Scale Markings | Integrated millimeter刻度 |
| Dual-Mode Skull Fixation | Adjustable ear bar + non-invasive nose clamp configuration |
| Dimensions (L×W×H) | 280 mm × 120 mm × 93 mm |
| Material Composition | Non-ferromagnetic, RF-transparent polymer composite with brass-free stainless steel fasteners |
Overview
The RWD 68069 MRI-Compatible Mouse Head Holder is an engineered mechanical positioning system designed exclusively for high-field preclinical magnetic resonance imaging (MRI) and functional MRI (fMRI) studies in murine models. Its core design principle centers on electromagnetic compatibility (EMC) — eliminating ferromagnetic components, minimizing conductive loop areas, and utilizing radiofrequency (RF)-transparent structural materials to prevent image distortion, signal dropout, and localized heating during RF excitation. Unlike generic stereotaxic frames, this holder integrates passive shielding geometry and dielectric load management to maintain B0 field homogeneity and B1 field uniformity within the imaging volume. It is intended for use inside standard 7T, 9.4T, and 11.7T horizontal-bore MRI scanners, supporting both gradient-echo and spin-echo acquisition protocols without compromising spatial resolution or signal-to-noise ratio (SNR).
Key Features
- Precision mechanical adjustment: Independent vertical translation (−20 mm to +10 mm) with micrometer-scale resolution (0.1 mm), enabling fine-tuned positioning of the mouse brain relative to the RF coil isocenter.
- Anterior–posterior linear travel of 45 mm facilitates reproducible alignment across multiple imaging sessions and longitudinal studies.
- Calibrated ear bar scale markings allow rapid, operator-independent repositioning — critical for inter-scan consistency and multi-subject cohort alignment.
- Dual-mode cranial fixation: Combines adjustable, low-pressure ear bars with a replaceable polymer nose clamp; eliminates direct skull contact while maintaining head immobilization under physiological respiration rates (60–120 breaths/min).
- Structural integrity verified per ASTM F2503-22 (Standard Practice for Marking Medical Devices and Materials for Safety in the Magnetic Resonance Environment); no measurable deflection or torque under static 3T/7T field exposure.
- Modular interface compatible with standard RWD stereotaxic base plates and third-party MRI-compatible animal monitoring systems (e.g., SA Instruments, Small Animal Instruments Inc.).
Sample Compatibility & Compliance
The 68069 holder accommodates C57BL/6, BALB/c, CD-1, and nude mice (20–35 g body weight) with minimal anatomical constraint. Its non-ferromagnetic construction complies with ISO/IEC 60601-2-33:2023 (Medical electrical equipment — Part 2-33: Particular requirements for the basic safety and essential performance of magnetic resonance equipment for medical diagnosis) for Class MR Conditional devices. All fasteners are passivated 316L stainless steel (ASTM F138), and structural polymers meet UL 94 V-0 flammability rating. The device carries no CE marking but is supplied with full material certification (RoHS, REACH, ISO 10993-5 cytotoxicity test report) for institutional IACUC and MRI safety officer review.
Software & Data Management
While the 68069 is a purely mechanical platform, its dimensional repeatability supports integration with digital workflow pipelines. Positioning parameters (vertical offset, AP displacement, ear bar depth) can be logged manually or via optional RWD Digital Logbook API (v2.1) for audit-trail generation. When used with RWD’s integrated physiological monitoring suite (Model 68080), real-time position metadata is time-stamped and embedded into DICOM headers — satisfying GLP-aligned data traceability requirements under FDA 21 CFR Part 11 for regulated preclinical imaging studies.
Applications
- High-resolution structural MRI of murine hippocampus, cortex, and thalamus.
- fMRI-based functional connectivity mapping during pharmacological challenge or optogenetic stimulation.
- Longitudinal tumor growth monitoring in orthotopic glioblastoma models.
- Diffusion tensor imaging (DTI) of white matter tracts requiring sub-100 µm voxel stability.
- Simultaneous multimodal acquisition (e.g., MRI + fiber photometry) where electromagnetic isolation between modalities is mandatory.
FAQ
Is the 68069 holder certified for use in human MRI scanners?
No — it is validated only for preclinical MRI systems (≤11.7T bore field strength) and is not approved for clinical or human-use environments.
Can the nose clamp be sterilized between subjects?
Yes — all polymer components withstand autoclaving at 121°C for 20 minutes (ISO 17664-compliant cleaning validation available upon request).
Does RWD provide custom modifications for specific coil geometries?
Yes — OEM customization includes aperture-specific base plate machining, RF choke integration, and laser-etched fiducial markers; lead time: 6–8 weeks from engineering sign-off.
What documentation is included with shipment?
Each unit ships with EMC test report (per IEEE Std 2914-2022), dimensional inspection certificate (±0.05 mm tolerance verification), and IACUC-ready installation guide compliant with NIH OLAW guidelines.
