MKX-E1B Makewave Microwave Solvent-Free Extraction System
| Brand | Makewave |
|---|---|
| Origin | Shandong, China |
| Manufacturer Type | Original Equipment Manufacturer (OEM) |
| Country of Origin | China |
| Model | MKX-E1B |
| Microwave Power | 800 W (continuous, non-pulsed) |
| Microwave Frequency | 2450 MHz |
| Temperature Control Range | 0–300 °C |
| Temperature Accuracy | ±1 °C |
| Cavity Material | 304 Stainless Steel with Multi-Layer PTFE Coating |
| Cavity Volume | ~20 L |
| Maximum Vessel Capacity | 2000 mL |
| Microwave Leakage | <5 mW/cm² |
| Power Supply | 220 V AC / 50 Hz |
| Total Power Consumption | 2000 W |
| Dimensions (W×H×D) | 350 × 1350 × 360 mm |
| Weight | 65 kg |
| Certification | ISO 9001 Certified |
Overview
The MKX-E1B Makewave Microwave Solvent-Free Extraction System is an open-atmosphere, continuous-wave microwave platform engineered for thermal-assisted, solvent-free extraction of thermolabile and volatile bioactive compounds from botanical and zoological matrices. Unlike conventional Soxhlet or ultrasonic-assisted methods requiring organic solvents, this system leverages selective dielectric heating at 2450 MHz to rapidly elevate intracellular moisture and interstitial water into superheated steam—generating in situ pressure differentials that rupture cell walls and facilitate volatilization and condensation-driven separation. Its design adheres to the principles of green analytical chemistry (ISO/IEC 17025:2017 Annex A.3), minimizing environmental footprint while maintaining compatibility with GLP-compliant workflows in regulatory laboratories.
Key Features
- Open-vessel architecture operating at ambient pressure—eliminates high-pressure vessel safety certification requirements and enables real-time visual monitoring via dual observation pathways: a borosilicate glass viewport with integrated LED illumination and a high-resolution color video surveillance system.
- 2000 mL capacity extraction vessel fabricated from heat-resistant borosilicate glass with PTFE-sealed joints; compatible with gravity-driven condensate reflux and phase separation, supporting both hydrodistillation and steam distillation protocols per ASTM D7464-21 and ISO 9235:2013.
- Non-pulsed, continuously adjustable 800 W microwave output with closed-loop power modulation—ensuring stable energy delivery across variable sample dielectric loads without thermal runaway.
- Infrared temperature sensing mounted circumferentially around the extraction vessel sidewall, enabling direct surface temperature measurement independent of cavity air conditions—critical for reproducible kinetic control in essential oil yield optimization.
- PLC-based control architecture with 7-inch resistive touchscreen HMI; stores up to 99 user-defined method programs with timestamped parameter logging (time, temperature, power, video frame index).
- Integrated negative-pressure exhaust fan with activated carbon filtration—removes volatile organic compounds and acidic vapors generated during prolonged extractions of resinous or alkaloid-rich tissues.
Sample Compatibility & Compliance
The MKX-E1B accommodates heterogeneous solid samples including dried herbs, crushed seeds, fungal mycelia, marine biomass, and minced animal tissues—provided particle size remains ≤5 mm to ensure uniform microwave coupling. It complies with IEC 61000-4-3 (radiated immunity) and GB 4706.21-2008 (microwave appliance safety). The PTFE-coated 304 stainless steel cavity meets USP material compatibility requirements for pharmaceutical extractables testing. All firmware operations generate audit-trail logs compliant with FDA 21 CFR Part 11 (electronic records and signatures) when paired with validated network storage.
Software & Data Management
Data acquisition occurs at 1 Hz resolution and is stored locally on industrial-grade SD card (included). Export formats include CSV (for Excel and MATLAB analysis) and PNG screenshots of real-time curves. Optional Ethernet/Wi-Fi module enables remote monitoring via web browser interface and integration into LIMS environments using RESTful API endpoints. Firmware supports time-stamped video metadata embedding—each frame tagged with synchronized temperature/power values for forensic traceability during method validation.
Applications
- Natural product research: Isolation of monoterpenes, sesquiterpenes, and phenylpropanoids from Citrus, Lavandula, and Origanum spp. with >92% recovery vs. hydrodistillation (validated per AOAC 985.22).
- Residue analysis: Rapid screening of organophosphate pesticide residues in leafy vegetables prior to GC-MS/MS quantification—reducing sample prep time by 65% compared to QuEChERS.
- Phytochemical standardization: Batch-to-batch consistency assessment of Ginkgo biloba terpene lactone content under USP monograph guidelines.
- Academic teaching labs: Demonstrating microwave-specific thermal gradients and mass transfer kinetics in undergraduate physical chemistry curricula.
FAQ
Does the MKX-E1B require external cooling water?
Yes—integrated condenser operation requires a recirculating chiller or tap-water supply delivering ≥1.5 L/min at ≤15 °C.
Can the system perform sequential multi-step extractions in one run?
Yes—programmable multi-stage protocols allow ramp-hold-cool cycles with automatic power modulation between stages.
Is third-party calibration support available?
Makewave provides NIST-traceable IR sensor calibration certificates; field verification services are offered globally through ISO/IEC 17025-accredited partners.
What maintenance intervals are recommended?
PTFE cavity coating inspection every 500 operational hours; door gasket replacement every 12 months or after 2000 door cycles.
How is method transfer validated between instruments?
Built-in “Method Replication Mode” exports full parameter sets—including video timestamps and thermal profiles—for cross-platform verification per ICH Q5C guidelines.
