Bioer New XP Series Thermal Cyclers (TC-XP-E / TC-XP-F / TC-XP-H)
| Brand | Bioer |
|---|---|
| Origin | Zhejiang, China |
| Manufacturer Type | Authorized Distributor |
| Instrument Type | Gradient PCR Thermal Cycler |
| Sample Capacity | 96-well (TC-XP-E), 48×2 dual-block (TC-XP-D), 384-well (TC-XP-F), or 4-slide in situ hybridization platform (TC-XP-H) |
| Heating Rate | ≥4 °C/s |
| Temperature Accuracy | ±0.3 °C |
| Well-to-Well Uniformity | ±0.4 °C |
| Gradient Range | 1–30 °C across 12 or 24 columns |
| Temperature Control Range | 4–99.9 °C |
| Dimensions (L×W×H) | 470 × 340 × 260 mm |
| Net Weight | 10 kg |
Overview
The Bioer New XP Series Thermal Cyclers (models TC-XP-E, TC-XP-F, and TC-XP-H) are precision-engineered gradient thermal cyclers designed for high-fidelity polymerase chain reaction (PCR) amplification in molecular biology laboratories. Based on Peltier-based thermoelectric heating and cooling architecture, these instruments deliver rapid thermal transitions and tightly controlled ramping profiles essential for demanding applications including high-resolution melt analysis (HRM), touchdown PCR, multiplex amplification, and fast-cycling protocols. The system employs real-time closed-loop temperature feedback via high-stability platinum resistance thermometers (Pt1000) embedded directly beneath each well position, ensuring traceable thermal accuracy and reproducibility across the full operational range of 4–99.9 °C. Designed to meet routine and advanced nucleic acid amplification requirements, the XP Series supports modular configuration—enabling seamless transition between standard 96-well, dual-format (48×0.2 mL + 30×0.5 mL), high-density 384-well, and in situ hybridization (ISH) workflows without hardware modification.
Key Features
- High-speed thermal cycling with ≥4 °C/s average heating rate and comparable cooling kinetics, reducing total run time by up to 35% versus conventional cyclers.
- Advanced gradient functionality: programmable linear temperature gradients across 12 or 24 columns (model-dependent), enabling empirical optimization of annealing conditions in a single run.
- Ultra-stable thermal uniformity: ±0.4 °C well-to-well variation across the entire block surface, validated per ISO 13485-compliant calibration procedures.
- Intelligent auto-detection of installed thermal block modules—no manual configuration required; firmware automatically loads optimal control parameters for each module type.
- Large-capacity, high-contrast 7-inch TFT LCD touchscreen with intuitive icon-driven navigation, supporting multi-language UI (English, Chinese, Spanish, French).
- Robust aluminum alloy heating block with gold-plated contact surfaces for enhanced thermal conductivity and long-term corrosion resistance.
- Integrated USB 2.0 port and optional Ethernet interface for secure data export and remote monitoring under networked lab environments.
Sample Compatibility & Compliance
The XP Series accommodates a broad spectrum of consumables: standard 0.2 mL skirted and semi-skirted PCR tubes, 96-well and 384-well plates (full-skirt, semi-skirt, and low-profile), and proprietary ISH slides for spatial nucleic acid detection. All models comply with IEC 61010-1:2010 safety standards for laboratory electrical equipment and electromagnetic compatibility (EMC) per IEC 61326-1:2020. Firmware supports audit trail generation and user-access logging aligned with GLP and GMP documentation practices. While not FDA 510(k)-cleared as an IVD device, the instrument is routinely deployed in CLIA-certified and CAP-accredited laboratories for research-use-only (RUO) and assay development applications.
Software & Data Management
The XP Control Software (v3.2+) provides comprehensive protocol management, including nested cycling steps, variable ramp rates, pause/resume functions, and real-time graphical visualization of temperature vs. time profiles during execution. Data files are saved in vendor-neutral CSV format with embedded metadata (user ID, timestamp, block ID, thermal profile checksum). Optional software modules support LIMS integration via HL7 or ASTM E1384 interfaces and enable electronic signature capture compliant with 21 CFR Part 11 when paired with validated identity verification systems. All software updates are digitally signed and delivered via encrypted HTTPS channels.
Applications
- Gene expression profiling via RT-qPCR using SYBR Green or probe-based chemistries.
- Pathogen detection and genotyping in clinical microbiology and public health surveillance.
- CRISPR guide RNA validation and off-target assessment through amplicon sequencing library preparation.
- Forensic STR amplification requiring stringent thermal fidelity and inter-run reproducibility.
- In situ PCR and hybridization chain reaction (HCR) workflows on fixed tissue sections using the TC-XP-H module.
- Quality control of synthetic DNA constructs and plasmid preparations in biomanufacturing settings.
FAQ
Does the XP Series support external triggering or synchronization with other instruments?
Yes—via TTL-compatible digital I/O port (optional accessory), enabling precise coordination with fluorescence imagers, liquid handlers, or robotic arms.
Can users import custom thermal profiles from third-party software?
Yes—CSV-formatted cycle definitions with time/temperature/ramp rate columns can be imported and validated prior to execution.
Is block calibration traceable to national metrology institutes?
Calibration certificates include NIST-traceable references for temperature sensors and are issued upon request with annual recalibration service options.
What maintenance is required to sustain thermal performance over time?
Annual verification of block uniformity and gradient linearity is recommended; no consumable parts require replacement under normal operating conditions.
How does the XP Series handle power interruptions during long runs?
Built-in non-volatile memory retains active program state and resumes from last completed cycle upon power restoration, provided backup battery remains functional.
