Peak Scientific Infinity 1045 Nitrogen Generator for Bruker EVOQ Triple Quadrupole Mass Spectrometers

Overview

The Peak Scientific Infinity 1045 Nitrogen Generator is an engineered, purpose-built gas supply system designed specifically to meet the stringent carrier gas requirements of the Bruker EVOQ Triple Quadrupole mass spectrometer. Utilizing proprietary hollow-fiber membrane separation technology, the Infinity 1045 continuously extracts high-purity nitrogen from compressed ambient air by selectively permeating oxygen, water vapor, and other trace gases—leaving behind a stable, consistent stream of nitrogen with purity up to 99.5% and a dew point of -40°C. This performance envelope aligns precisely with the operational specifications defined by Bruker for EVOQ LC-MS/MS systems, including required flow stability, pressure regulation, and particulate/gas-phase contaminant limits. Unlike cryogenic or PSA-based alternatives, membrane separation offers inherently low maintenance, zero consumables (beyond standard filter elements), and silent operation—making it ideal for integration into noise-sensitive analytical laboratories where uninterrupted 7×24 operation is routine.

Key Features

• Application-specific engineering for Bruker EVOQ Triple Quadrupole MS systems, validated against instrument OEM gas interface specifications
• Dual-output architecture: dedicated 32 L/min nitrogen stream for LC-MS carrier gas + independent 50 L/min dry air output for instrument pneumatic functions (e.g., nebulizer gas, curtain gas, or auxiliary instrumentation)
• Integrated multi-stage filtration: coalescing pre-filter, activated carbon adsorber, and ultra-low particulate final filter (≤0.01 µm) compliant with ISO 8573-1 Class 2:2:1 for solid particles, water, and oil aerosols
• Passive thermal management and brushless DC motor-driven air compressor eliminate mechanical vibration and acoustic emission (<45 dBA at 1 m)
• Modular design with front-access service points enables rapid field replacement of filters and membrane modules without tools or system depressurization
• Onboard pressure-regulated output with real-time digital monitoring of nitrogen flow, outlet pressure, and dew point via integrated sensors

Sample Compatibility & Compliance

The Infinity 1045 delivers nitrogen that meets or exceeds the gas quality criteria specified in Bruker’s EVOQ System Installation and Operation Manuals for LC-MS applications. Its output is compatible with all electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) source configurations used on the EVOQ platform. The system conforms to ISO 8573-1:2010 for compressed air quality and supports laboratory adherence to GLP and GMP environments through documented maintenance logs and traceable filter change records. While not directly regulated under FDA 21 CFR Part 11, its stable, auditable gas delivery contributes to data integrity in regulated bioanalytical workflows—particularly in pharmaceutical QC/QA labs performing method validation per ICH M10 and USP .

Software & Data Management

The Infinity 1045 operates as a standalone, microprocessor-controlled unit with no external software dependency. All operational parameters—including runtime hours, filter service intervals, and sensor health status—are stored in non-volatile memory and accessible via the front-panel LCD interface. Optional RS-232 or analog 4–20 mA outputs enable integration into building management systems (BMS) or centralized lab infrastructure monitoring platforms. For laboratories implementing electronic record retention, Peak provides calibration certificates, factory test reports, and installation qualification (IQ) documentation aligned with ASTM E2500 and ISO/IEC 17025 requirements. No proprietary drivers or cloud connectivity are required, ensuring compatibility with air-gapped or IT-restricted analytical networks.

Applications

• Carrier gas supply for Bruker EVOQ Triple Quadrupole LC-MS/MS systems in quantitative bioanalysis (e.g., PK/PD studies, therapeutic drug monitoring)
• Dry air source for pneumatic components in LC autosamplers, column ovens, and detector cooling systems
• Backup or primary nitrogen source in regulated pharmaceutical labs conducting GLP-compliant small-molecule assays
• Gas supply for multiple parallel instruments when deployed with passive manifold distribution (with appropriate pressure drop calculation)
• Replacement for liquid nitrogen dewars in high-throughput environmental testing labs seeking reduced logistics overhead and improved safety compliance

FAQ

Is the Infinity 1045 certified for use with Bruker EVOQ instruments?
Yes—the Infinity 1045 is a Bruker-validated accessory and listed in Bruker’s official Gas Supply Compatibility Matrix for the EVOQ series.
What inlet air quality is required?
Compressed air must be oil-free, with inlet pressure between 120–145 psi and dew point ≤3°C; a refrigerated dryer and coalescing filter upstream are strongly recommended.
Can the nitrogen and dry air outputs be used simultaneously?
Yes—both streams operate independently and concurrently, each with dedicated pressure regulation and flow stabilization.
Does the system require annual recalibration?
No—membrane separation performance is inherently stable; only scheduled filter replacements (every 6–12 months depending on ambient conditions) are required.
Is remote monitoring supported?
Basic status signals (ready/fault) are available via dry-contact relay; full telemetry requires optional analog or serial interface modules.