TS-NS Series Integrated Extraction and Concentration Unit
| Origin | Shanghai, China |
|---|---|
| Manufacturer Type | Authorized Distributor |
| Origin Category | Domestic (China) |
| Model | TS-NS |
| Pricing | Upon Request |
| Volumes | 5 L, 10 L, 20 L, 30 L, 50 L, 100 L |
| Heating Power | 5–20 kW |
| Jacket Pressure | 0.3–0.4 MPa |
| Internal Tank Pressure | 0.09 MPa |
| Extraction Temperature | 100 °C |
| Concentration Temperature Range | 40–80 °C |
| Stirring Motor Power | 0.09–0.40 kW |
| Condensing Area | 0.20–0.95 m² |
| Heating Surface Area | 0.20–0.95 m² |
| Vacuum Pump Power | 0.75–2.25 kW |
| Ultimate Vacuum | −0.05 to −0.08 MPa |
| Dimensions (L×W×H, mm) | 1500×1200×550 to 2200×1550×660 |
| Construction Material | SUS304 stainless steel, interior welds polished to 300-grit finish |
| Insulation | Triple-layer thermal insulation |
| CIP System | Integrated Clean-in-Place |
| Heating Method | Electric jacketed heating |
| Optional Ultrasound Frequencies | 15, 20, 28, 30, 35, 40, 50, 60 kHz |
| Compliance | Designed in accordance with GMP principles for pharmaceutical R&D environments |
Overview
The TS-NS Series Integrated Extraction and Concentration Unit is an engineered solution for laboratory-scale and pilot-scale solid–liquid extraction and subsequent solvent recovery or product concentration. Based on the principle of thermal reflux extraction—where heated solvent vapor condenses and returns continuously to the extraction vessel—the system enables high-efficiency mass transfer under controlled temperature and pressure conditions. When equipped with optional ultrasonic transducers, the unit leverages acoustic cavitation to disrupt plant cell walls, enhancing solute diffusion kinetics without thermal degradation. This dual-mode capability (conventional thermal reflux and ultrasound-assisted extraction) supports method development across natural product isolation, botanical standardization, and active pharmaceutical ingredient (API) purification. The modular architecture integrates extraction, concentration, condensation, and solvent recycling into a single compact footprint—reducing infrastructure demands while maintaining process traceability and repeatability required in regulated R&D settings.
Key Features
- Compact, open-frame design with triple-layer thermal insulation minimizes energy loss and ensures stable thermal profiles during prolonged operation.
- Centralized PLC-based control panel provides real-time monitoring and adjustment of extraction temperature (up to 100 °C), concentration temperature (40–80 °C), vacuum level (−0.05 to −0.08 MPa), and stirring speed.
- SUS304 stainless steel construction throughout—including 300-grit electropolished internal welds—ensures corrosion resistance, cleanability, and compliance with pharmaceutical-grade surface finish requirements.
- Integrated Clean-in-Place (CIP) system eliminates manual disassembly for routine sanitation; arc-shaped tank geometry prevents dead zones during both extraction and cleaning cycles.
- Optional ultrasonic module features frequency-selectable transducers (15–60 kHz) and frame-type agitator to ensure uniform acoustic energy distribution across large-volume batches (up to 100 L), significantly improving extraction yield and reproducibility for thermolabile compounds.
- Electrically heated jacket with precise pressure regulation (0.3–0.4 MPa) enables rapid, uniform heating without external steam infrastructure—only water and electrical supply are required.
Sample Compatibility & Compliance
The TS-NS unit accommodates diverse feedstock forms including dried herbs, powdered botanicals, granular extracts, and macerated biomass. It supports aqueous, hydroalcoholic, and organic solvent systems (e.g., ethanol, ethyl acetate, hexane) under atmospheric, pressurized, or vacuum-assisted conditions. Its design aligns with core elements of Good Manufacturing Practice (GMP) for pharmaceutical R&D laboratories, including material traceability, equipment qualification readiness, and process parameter logging. While not certified for commercial manufacturing, the system meets foundational criteria referenced in ISO 22000 (food safety), USP (extraction validation), and ICH Q5A (biotechnological product characterization). All models are compatible with GLP-compliant documentation workflows when paired with validated data acquisition software.
Software & Data Management
The embedded controller logs time-stamped records of temperature, pressure, vacuum level, stirring speed, and operating duration. Export functionality supports CSV output for integration into laboratory information management systems (LIMS) or electronic lab notebooks (ELN). For enhanced regulatory alignment, optional software add-ons provide 21 CFR Part 11-compliant audit trails, user access controls, and electronic signature capability—enabling full data integrity in preclinical and formulation development studies. Historical batch data can be correlated with downstream analytical results (e.g., HPLC, UV-Vis) to establish process–quality relationships.
Applications
- Phytochemical research: Isolation of flavonoids, alkaloids, saponins, and polysaccharides from medicinal plants under optimized thermal or ultrasound-assisted protocols.
- Functional food development: Extraction of anthocyanins, carotenoids, and polyphenols with minimal thermal exposure to preserve antioxidant activity.
- Essential oil production: Steam distillation-compatible configuration for aromatic compound recovery via hydrodistillation or steam infusion.
- API process screening: Solvent selection, residence time optimization, and yield modeling for early-phase extraction route development.
- Academic teaching labs: Demonstrating mass transfer fundamentals, phase equilibrium, and unit operation integration in chemical and pharmaceutical engineering curricula.
FAQ
What solvent systems are compatible with the TS-NS unit?
The system supports water, ethanol, methanol, acetone, ethyl acetate, and other low-to-medium boiling point solvents. Compatibility verification is recommended for chlorinated or highly corrosive solvents.
Can the unit operate under inert atmosphere?
Yes—optional nitrogen purge ports and pressure-rated seals allow operation under controlled N₂ blanket for oxygen-sensitive extractions.
Is validation support available for GMP-aligned installations?
IQ/OQ documentation templates and calibration certificates for critical sensors (PT100 temperature probes, pressure transducers) are provided upon request.
How is ultrasonic energy delivered uniformly across large volumes?
The frame-type agitator ensures continuous repositioning of solid matrix relative to fixed-position ultrasonic horns, while frequency selection optimizes cavitation intensity for specific particle size distributions.
What maintenance intervals are recommended for long-term reliability?
Vacuum pump oil replacement every 500 hours, gasket inspection quarterly, and ultrasonic transducer impedance testing annually—full service schedule included in operator manual.
