Rainin Pos-D External Piston Manual Pipette MR-10

Overview

The Rainin Pos-D External Piston Manual Pipette MR-10 is a precision-engineered single-channel liquid handling instrument designed for accurate, repeatable dispensing of challenging fluids—including high-density, viscous, volatile, or temperature-sensitive samples. Unlike air-cushion pipettes, the Pos-D operates on a positive displacement principle: a disposable, integrated piston moves within a sealed capillary tip, making direct contact with the sample. This eliminates the compressible air gap, thereby removing vapor pressure effects, bubble formation, and aspiration/dispense variability caused by fluid compressibility or surface tension. The MR-10 model is calibrated for a nominal volume range of 0.5–10 µL, with resolution to 0.1 µL and mechanical volume adjustment confirmed by a large, unambiguous digital display visible from multiple angles. Its design adheres to ISO 8655-2 (2022) requirements for positive displacement pipettes, ensuring metrological integrity across laboratory environments—from QC microbiology to analytical chemistry and pharmaceutical formulation development.

Key Features

• External piston architecture with fully disposable, pre-assembled capillary tips—no internal lubrication, no maintenance, no recalibration required between tip changes
• Magnetic-assisted manual actuation delivers consistent plunger force and reduced hand fatigue during repetitive operations
• Ergonomic finger-hook grip and low center-of-gravity balance minimize wrist torque and support extended use under ISO 7250-1 anthropometric guidelines
• Volumetric setting is mechanically locked and optically verified via high-contrast digital display—no parallax error, no accidental drift
• Tip compatibility with Gilson Microman®-format external piston tips enables seamless integration into existing workflows and inventory systems
• No internal seals or O-rings exposed to aggressive solvents—ideal for DMSO, glycerol, ethanol, acetonitrile, and other low-surface-tension or corrosive media

Sample Compatibility & Compliance

The Pos-D MR-10 excels where conventional air-displacement pipettes fail: with liquids exhibiting viscosities >100 mPa·s (e.g., molten polymers, cell lysates, RNA extraction buffers), saturated vapors (e.g., chloroform, ether), or high densities (>1.5 g/cm³). Its positive displacement mechanism ensures volumetric fidelity independent of ambient temperature, humidity, or operator technique—critical for USP analytical instrument qualification and ASTM E2758-21 method validation. All components comply with RoHS 2011/65/EU and REACH SVHC regulations. Calibration documentation supports traceability to NIST-traceable standards, and routine verification meets ISO/IEC 17025 requirements for accredited testing laboratories.

Software & Data Management

While the MR-10 is a standalone manual device, its design integrates seamlessly into digital lab ecosystems. Volume settings are physically immutable during operation—eliminating software-dependent configuration errors. Each pre-assembled tip carries a lot-specific certificate of conformance, enabling full audit trail linkage in LIMS or ELN platforms (e.g., LabWare, Benchling, Veeva Vault). For labs operating under FDA 21 CFR Part 11, the absence of embedded firmware or electronic memory removes validation burden—only mechanical calibration records and tip lot traceability require archiving. Rainin provides downloadable ISO 8655-compliant test protocols and uncertainty budgets for internal verification.

Applications

• Precise dispensing of nanoliter-scale reagents in qPCR master mix preparation and digital PCR partitioning
• Accurate transfer of viscous enzyme solutions (e.g., Taq polymerase in glycerol suspension) without under-delivery
• Handling volatile organic solvents in HPLC mobile phase preparation and residual solvent analysis
• Cell culture applications involving serum-rich or phenol-containing media where aerosol containment is critical
• Microfluidic device loading, inkjet calibration standards, and thin-film deposition workflows requiring sub-microliter repeatability

FAQ

How does the Pos-D differ from standard air-displacement pipettes?
It uses direct piston-to-liquid contact inside a disposable capillary tip—no air cushion—making it insensitive to vapor pressure, viscosity, and temperature fluctuations.
Can I use third-party external piston tips?
Yes—MR-10 is compatible with all Gilson Microman®-format external piston tips meeting ISO 8655-3 dimensional tolerances.
Is calibration required before first use?
No—each unit ships with factory calibration verified per ISO 8655-2; however, user verification using gravimetric methods is recommended prior to critical applications.
What maintenance does the MR-10 require?
None beyond routine visual inspection and cleaning of the exterior with 70% ethanol; no internal parts require servicing or replacement.
Does the MR-10 support GLP-compliant documentation?
Yes—Rainin supplies calibration certificates, tip lot traceability data, and ISO-aligned verification templates suitable for audit readiness.