Rainin AutoRep Adjustable Electronic and Manual Bottle Top Dispensers

Overview

The Rainin AutoRep series comprises two high-precision, ergonomically engineered bottle top dispensers—AutoRep E (electronic) and AutoRep S (manual)—designed for reliable, repeatable liquid handling across research, quality control, and routine laboratory workflows. Built on the proven piston-driven positive displacement principle, the AutoRep system eliminates air-cushion variability inherent in air-displacement pipettes, ensuring consistent accuracy regardless of liquid viscosity, volatility, or temperature. Each dispenser mounts directly onto standard GL45 or GL32 reagent bottles and operates via a calibrated, externally mounted piston mechanism that delivers defined aliquots with minimal operator effort. The AutoRep E integrates a microprocessor-controlled drive system that reads the installed syringe tip’s nominal volume—eliminating manual range misconfiguration—and executes programmed dispense steps with sub-microliter resolution. The AutoRep S employs a precision-machined mechanical gear train and tactile volume dial, enabling intuitive, tool-free adjustment across its full 2 µL–5 mL range. Both models comply with ISO 8655-3 for repeater pipettes, supporting traceable calibration and performance verification under GLP/GMP conditions.

Key Features

• Positive displacement architecture ensures high reproducibility for aqueous, viscous, volatile, and dense liquids—including DMSO, glycerol, ethanol, and cell culture media.
• Ergonomic design reduces repetitive strain: low actuation force (<0.8 N for AutoRep S; near-zero for AutoRep E), balanced weight distribution, and non-slip grip surfaces.
• AutoRep E automatically detects syringe tip volume via embedded encoding—no user input required—minimizing setup errors and supporting audit-ready documentation.
• Up to 49 consecutive dispenses without refilling (dependent on syringe tip capacity and set volume), significantly improving throughput in serial dilution or plate-filling protocols.
• Modular syringe tip system: 10 pre-calibrated, factory-assembled piston tips (0.1 mL to 50 mL), available sterile or non-sterile, each individually packaged with integrity seals.
• AutoRep E includes rechargeable NiMH battery pack, charging base, and universal AC adapter; AutoRep S includes dual-sided volume setting card and wall-mountable shelf bracket.

Sample Compatibility & Compliance

The AutoRep platform is validated for use with Class I and II liquids per ISO 8655-3, including organic solvents, acids, bases, and biological buffers. Its chemically resistant PTFE, FEP, and ETFE wetted materials ensure compatibility with aggressive reagents (e.g., concentrated HCl, NaOH, acetone). All syringe tips undergo functional testing at multiple volume points and are supplied with individual calibration certificates traceable to NIST standards. The system supports compliance with FDA 21 CFR Part 11 when integrated with Rainin’s certified software platforms (e.g., Liquidator Control Suite), enabling electronic signatures, audit trails, and secure user access controls. Routine verification follows ASTM E2758 and ISO/IEC 17025 guidelines for volumetric equipment.

Software & Data Management

AutoRep E interfaces via USB-C with Rainin’s Liquidator Control Suite (v3.2+), a validated desktop application supporting method storage, dispense protocol sequencing, real-time status monitoring, and export of CSV-formatted dispense logs. Each dispense event is timestamped and logged with tip ID, volume, step count, and battery level—enabling full traceability for regulatory submissions. The software enforces role-based access (Administrator, Technician, Viewer) and generates PDF reports compliant with ALCOA+ principles. For standalone operation, AutoRep E stores up to 20 user-defined methods internally and retains configuration data during power loss.

Applications

• High-throughput assay setup: serial dilutions, ELISA plate filling, PCR master mix preparation.
• QC/QA laboratories: standardized reagent addition in pharmacopeial tests (USP , EP 2.6.12).
• Cell culture facilities: precise dispensing of growth factors, antibiotics, and trypsin solutions without aerosol generation.
• Chemistry labs: controlled delivery of catalysts, titrants, or hazardous reagents from stock bottles.
• Biomanufacturing: buffer and media preparation under cGMP conditions using sterile syringe tips and validated methods.

FAQ

What is the difference between AutoRep E and AutoRep S?
AutoRep E is an electronically controlled dispenser with microprocessor-driven precision, automatic tip recognition, and programmable multi-step dispensing. AutoRep S is a manually operated, mechanically calibrated repeater pipette optimized for simplicity, portability, and rapid volume adjustment.
Are sterile syringe tips certified for use in ISO Class 5 environments?
Yes—sterile syringe tips are gamma-irradiated (25 kGy), supplied in individually wrapped, ISO 11607-compliant packaging, and certified to meet ISO 13485 manufacturing requirements.
Can AutoRep E be used with non-Rainin bottles?
AutoRep E requires standard GL45 or GL32 threaded necks; adapters (e.g., ENC-10ADP) are available for compatibility with select non-standard containers.
How often should calibration be performed?
Per ISO 8655-3, initial calibration is recommended upon installation; subsequent verification should occur at least quarterly—or after 10,000 dispense cycles—using gravimetric or photometric methods.
Is firmware update support available for AutoRep E?
Yes—firmware updates are distributed through Rainin’s Secure Update Portal and require authenticated login; all updates maintain backward compatibility with existing methods and tip configurations.