Mindray WATO EX-65 Pro Vet Veterinary Anesthesia Workstation
| Brand | Mindray |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | Authorized Distributor |
| Country of Origin | China |
| Model | WATO EX-65 Pro Vet |
| Instrument Type | Integrated Veterinary Anesthesia & Ventilation System |
| Regulatory Classification | Class II Medical Device (CN), CE-marked for Veterinary Use |
Overview
The Mindray WATO EX-65 Pro Vet is a CE-certified, integrated veterinary anesthesia workstation engineered for precision, safety, and adaptability across small to large animal species in research laboratories, academic veterinary hospitals, and GLP-compliant preclinical facilities. It combines real-time anesthetic gas delivery control with advanced pressure- and volume-targeted ventilation—grounded in fundamental respiratory physiology principles including pressure-controlled ventilation (PCV), volume-guaranteed synchronization (VG), and time-cycled pressure-limited breath delivery. Unlike general-purpose human ventilators, the WATO EX-65 Pro Vet incorporates species-specific default settings, adjustable inspiratory/expiratory time ratios (I:E), and low-flow anesthetic vaporizer integration pathways—enabling stable maintenance of surgical planes while minimizing physiological stress during prolonged procedures. Its architecture supports closed-loop monitoring integration (e.g., capnography, SpO₂, ECG, NIBP) via standardized analog/digital I/O ports compliant with ISO 80601-2-12 and IEC 60601-1-6 usability requirements.
Key Features
- Multi-modal ventilation engine supporting SIMV-VG (Synchronized Intermittent Mandatory Ventilation with Volume Guarantee), CPAP/PS (Continuous Positive Airway Pressure / Pressure Support), and APRV (Airway Pressure Release Ventilation)—all configurable with species-adjustable parameters (e.g., respiratory rate: 5–120 bpm; tidal volume range: 20–2000 mL; inspiratory time: 0.2–4.0 s)
- Dual-pressure sensor architecture with dynamic flow compensation ensures ±3% tidal volume accuracy under variable airway resistance and compliance conditions typical in rodent, canine, feline, porcine, and non-human primate models
- Integrated vaporizer interface compatible with sevoflurane, isoflurane, and desflurane delivery systems; supports dual-agent administration with independent concentration control and real-time agent concentration feedback
- Real-time waveform display (flow-time, pressure-time, volume-time) with customizable scaling and freeze/zoom functionality for intraoperative assessment of respiratory mechanics
- Alarm system compliant with ISO 80601-2-12 Annex A—featuring priority-level alerts (high/medium/low), configurable thresholds, and event logging with timestamped audit trail for regulatory documentation
Sample Compatibility & Compliance
The WATO EX-65 Pro Vet is validated for use with endotracheal tubes ranging from 1.5 mm ID (neonatal rodents) to 12 mm ID (large swine or equine models), and accommodates both rebreathing and non-rebreathing circuits (e.g., Bain, Ayres T-piece, circle systems). All ventilation modes operate within defined limits per ASTM F2923-21 (Standard Specification for Veterinary Anesthesia Machines) and meet essential requirements of EN 13718-1:2021 (Anaesthetic and respiratory equipment — Anaesthesia workstations — Part 1: Anaesthesia workstations for veterinary use). Device firmware includes built-in self-test routines and calibration verification protocols traceable to NIST-equivalent reference standards. For GLP/GCP environments, the system supports optional 21 CFR Part 11-compliant electronic signature modules and audit-trail-enabled data export (CSV, PDF, XML).
Software & Data Management
The embedded operating system features a touchscreen HMI with multi-language support (English, German, French, Spanish, Japanese) and intuitive workflow navigation. Ventilation parameters, gas concentrations, and vital sign overlays are stored locally with ≥72 hours of continuous waveform history and ≥10,000 event logs. Data export is supported via USB 2.0 and Ethernet (TCP/IP), enabling seamless integration into institutional LIMS or electronic health record (EHR) platforms. Optional Mindray eGateway software provides remote device status monitoring, centralized fleet management, and automated report generation aligned with ISO/IEC 17025 documentation frameworks.
Applications
- Preclinical pharmacology studies requiring stable anesthetic depth during PK/PD assessments in murine, rabbit, and NHP models
- Surgical neuroscience experiments involving craniotomy, intracranial electrode implantation, or functional MRI where precise CO₂ control and hemodynamic stability are critical
- Veterinary teaching laboratories performing hands-on instruction in anesthetic pharmacokinetics, respiratory mechanics, and intraoperative crisis management
- Toxicology inhalation studies utilizing controlled gas mixtures and synchronized ventilation to maintain target alveolar partial pressures
- Cardiovascular research models (e.g., myocardial infarction, heart failure) requiring APRV to mitigate atelectasis and improve oxygenation index without increasing peak inspiratory pressure
FAQ
Is the WATO EX-65 Pro Vet approved for use in FDA-regulated GLP studies?
Yes—when deployed with configured audit trail, user access controls, and electronic signature modules, it meets data integrity requirements outlined in OECD Principles on GLP and 21 CFR Part 11.
Can the device be integrated with third-party physiological monitors (e.g., ADInstruments PowerLab, Biopac MP160)?
Yes—via analog output (0–5 V DC) and TTL-compatible trigger signals, enabling synchronized acquisition of ventilator waveforms with electrophysiological or hemodynamic data streams.
Does the system support pediatric or neonatal rodent ventilation protocols?
Yes—through custom parameter presets, ultra-low tidal volume mode (down to 20 mL), and high-frequency capability (up to 120 bpm), validated for mice, rats, and guinea pigs under IACUC-approved protocols.
What calibration standards are used for flow and pressure sensors?
Flow sensors are calibrated against primary-standard dry-calibrated rotameters traceable to NIM (China National Institute of Metrology); pressure transducers are verified using deadweight testers certified to ISO/IEC 17025.
Is remote software update capability available?
Firmware updates are performed via secure USB media only—no internet-connected update mechanism is implemented to ensure air-gapped security compliance in regulated laboratory environments.
