Unchained Labs
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| Brand | Unchained Labs |
|---|---|
| Origin | USA |
| Model | Big Kahuna |
| Reaction Pressure Range | 0–400 PSI |
| Reaction Temperature Range | −15 to 150 °C |
| Catalyst Bed Volume | 5–25 mL |
| Liquid Handling | Automated reagent dispensing for solids, liquids, slurries, and viscous materials |
| pH Monitoring & Control | Real-time in-line pH sensing with automated titrant addition |
| Platform Integration | Simultaneous heating, cooling, stirring, suspension, precipitation, evaporation, and gas handling |
| Brand | Unchained Labs |
|---|---|
| Origin | USA |
| Model | Junior |
| Heating Stage Temp Range | RT–180 °C |
| Cooling Stage Temp Range | –20–120 °C |
| Magnetic Stirring Speed | 0–750 rpm |
| Heated Filtration Unit Temp Range | RT–120 °C |
| Filter Pore Size | 0.7 µm glass microfiber (binder-free) |
| Brand | Unchained Labs |
|---|---|
| Origin | USA |
| Model | Junior-PVDS |
| Temperature Range | -20–120 °C |
| Dissolved Oxygen Range | 0–5 mg/L |
| pH Range | 1–14 |
| Vial Compatibility | 8–60 mm diameter |
| Max Tray Weight | 1000 g (including enclosure) |
| Hopper Capacity | Powdernium™: 10–100 mL |
| SV Dispenser | 4 mL |
| Dispense Volume | 10–10,000 µL |
| Viscosity Range (for viscous liquids) | 1–1000 cP |
| Balance Capacity | 220 g |
| Balance Sensitivity | 0.01 mg |
| Brand | Unchained Labs |
|---|---|
| Origin | USA |
| Model | Leprechaun |
| Application | Single-particle immuno-structural analysis of lentiviral vectors and extracellular vesicles (e.g., exosomes) |
| Detection Principle | Fluorescence-based single-particle imaging coupled with antibody- and probe-mediated orthogonal labeling |
| Sensitivity | ≥1 × 10⁷ particles/mL |
| Particle Sizing Range | ~30–200 nm (diameter) |
| Capture Flexibility | Compatible with anti-VSV-G, anti-gp70, or user-provided custom capture antibodies |
| Nucleic Acid Detection | RNA-specific fluorescent probes (e.g., Quasar 670-labeled oligos) |
| Structural Discrimination | Simultaneous detection of capsid protein (e.g., p24), envelope glycoprotein (e.g., VSV-G), and genomic RNA |
| Aggregation Assessment | Quantitative resolution of monodisperse virions vs. dimers, trimers, and higher-order aggregates |
| Regulatory Alignment | Designed to support process development under ICH Q5A(R2), USP <1043>, and FDA CMC guidance for gene therapy products |
| Brand | Unchained Labs |
|---|---|
| Origin | Belgium |
| Manufacturer Type | Original Equipment Manufacturer (OEM) |
| Import Status | Imported |
| Model | Lunatic |
| Detection Time | 10 min per 96-well plate |
| Wavelength Accuracy | ±1 nm at ≤400 nm |
| BSA Detection Range | 0.02–275 mg/mL |
| DNA Detection Range | 1.5–13,750 ng/μL |
| Sample Types | Proteins, DNA, RNA, ssDNA, dsDNA, oligonucleotides |
| Sample Volume | 2 µL per well |
| Cuvette-Free Microfluidic Sample Handling | Yes |
| Plate Format | SBS-compliant 96-well microplate |
| Instrument Category | UV-Vis Microvolume Spectrophotometer for Biomolecular Quantification |
| Brand | Unchained Labs |
|---|---|
| Origin | USA |
| Model | MIPS |
| Temperature Range | −20 °C to 180 °C |
| Temperature Control Accuracy | ±1 °C |
| Reaction Units | 24 / 48 / 96 wells |
| Reaction Volume Capacity | 0–125 mL |
| Liquid Dispensing | 4-channel variable-pitch pipettor (9 / 13 / 30 mm) |
| Viscosity Handling | 1–1000 cP |
| Solid Dispensing | Powderium™ hopper (10–100 mL), SV vial (4 mL) |
| Balance Range | 0.0001–1200 g |
| Imaging Resolution | 1032 × 779 pixels |
| Stirring Speed | up to 750 rpm |
| Vibration Frequency | 50/60 Hz |
| Cap Sealing Range | vials 2–250 mL, height 32–86 mm |
| Brand | Unchained Labs |
|---|---|
| Origin | USA |
| Model | OSR (Optimization Sampling Reactor) |
| Reactor Type | High-Throughput Parallel Flow Reactor |
| Vessel Material | 316 Stainless Steel |
| Operating Pressure Range | Ambient to 400 PSI |
| Temperature Range | 20 °C to 200 °C |
| Individual Vessel Volume | 7–25 mL |
| Number of Parallel Stations | 8 |
| Vacuum Capability | Up to 400 PSI (gauge, positive pressure mode) |
| Control Architecture | Integrated LEA Software Platform |
| Compliance | Designed for GLP-compliant workflows with audit-trail-enabled data capture |
| Brand | Unchained Labs |
|---|---|
| Origin | USA |
| Model | Screening Pressure Reactor (SPR) |
| Reactor Type | High-Throughput Parallel Pressure Reactor |
| Vessel Capacity | 1–6 mL per chamber |
| Maximum Operating Pressure | 200 bar |
| Temperature Range | Ambient to 400 °C |
| Chamber Configurations | 24-, 48-, or 96-position modular array |
| Gas/Liquid Flow Control | 0–1 L/min |
| Construction Material | Electropolished Stainless Steel (316L) |
| Sealing Architecture | Single-point clamshell high-pressure seal |
| Vacuum Capability | ≤ 1 mbar (base vacuum), compatible with inert gas purging and pressurization up to 200 bar |
| Brand | Unchained Labs |
|---|---|
| Origin | Belgium |
| Manufacturer Type | Original Equipment Manufacturer (OEM) |
| Product Origin | Imported |
| Model | Sunscreen |
| Carrier Type | Lipid Nanoparticle (LNP) |
| Flow Rate Range | 0.1–30 mL/min |
| Maximum Flow Ratio | 5:1 |
| Sample Volume per Well | 400 µL – 2 mL |
| Brand | Unchained Labs |
|---|---|
| Origin | Belgium |
| Manufacturer Type | Manufacturer |
| Origin Category | Imported |
| Model | Uncle |
| Instrument Principle | Differential Scanning Fluorescence (DSF) |
| Measured Parameters | Tm, Tagg, Tonset, Isothermal Stability, Viral Capsid Stability, Viral Genome Release Temperature, Dye-based Tm (DSF), Hydrodynamic Size & Polydispersity Index (PDI), Tsize, Tagg660, Thermal Refolding Assay, Viscosity, kD, B22, G22, ΔG |
| Sample Volume | 9 µL |
| Protein Concentration Range | 0.05–300 mg/mL |
| Temperature Control Range | 15–95 °C |
| Sample Capacity | 48 samples |
| Sample Introduction Method | Quartz Capillaries |
| 21 CFR Part 11 Compliance | Yes |
| Dimensions | 54 cm × 50 cm × 58 cm |