DLAB DG1616RE High-Capacity High-Speed Refrigerated Centrifuge

Overview

The DLAB DG1616RE is a high-capacity, high-speed refrigerated benchtop centrifuge engineered for precision separation in demanding laboratory environments. Utilizing brushless DC motor technology and advanced active refrigeration, it delivers stable rotational performance across its full speed range (300–16,000 rpm), achieving a maximum relative centrifugal force (RCF) of 28,621 × g. Its thermally optimized chamber maintains temperature setpoints from −20 °C to +40 °C with ±1 °C accuracy over the full operating range, enabling reproducible pelleting of temperature-sensitive biomolecules—including nucleic acids, membrane vesicles, organelles, and viral particles. The unit’s robust mechanical architecture—featuring a rigid cast-aluminum chassis, dynamically balanced rotor assembly, and vibration-dampening feet—ensures operational stability even at maximum load and speed. Designed for compliance with ISO 13485 manufacturing standards and aligned with general laboratory safety requirements per IEC 61010-1, the DG1616RE supports routine use in GLP- and GMP-aligned workflows where traceability and process control are critical.

Key Features

• 7-inch capacitive LCD touchscreen interface with intuitive icon-based navigation and multilingual support (English, Spanish, French, German, Chinese)
• Programmable storage for up to 100 user-defined protocols—including speed, RCF, time, temperature, acceleration/deceleration ramp profiles, and auto-lid lock settings
• Dynamic imbalance detection system that monitors rotor vibration in real time and halts operation with visual and audible alerts upon deviation exceeding ISO 19438-compliant thresholds
• Magnetic door latch mechanism enabling secure, single-hand closure without mechanical wear or alignment drift over repeated cycles
• High-efficiency compressor-based cooling system capable of reaching +4 °C from ambient (23 °C) in under 7 minutes, with condensate management via internal evaporation ducts
• Autoclavable high-strength anodized aluminum rotors rated for full-cycle sterilization at 121 °C, 2 bar, 30 minutes—validated per ISO 17665-1 for reuse in sterile applications
• Nine-step programmable acceleration and deceleration ramps—including soft-brake mode—to minimize sample resuspension and improve pellet integrity for delicate particulates

Sample Compatibility & Compliance

The DG1616RE accommodates a wide range of tube formats including 15 mL and 50 mL conical tubes, 400 mL bottles, PCR strips, and custom adapters for microtiter plates. Its 4 × 400 mL capacity configuration supports high-throughput processing for bioprocessing intermediates, environmental sediment concentrates, and clinical plasma volume reduction. All rotors comply with ISO 21501-4 for particle size distribution validation when used with standardized reference materials. The instrument meets electromagnetic compatibility (EMC) requirements per EN 61326-1 and electrical safety standards per EN 61010-1. It supports audit-ready operation under FDA 21 CFR Part 11 when paired with optional DLAB CentriControl Pro software featuring electronic signatures, change logs, and user-access-level permissions.

Software & Data Management

CentriControl Pro (optional) provides PC-based remote monitoring, method transfer, and data export in CSV, PDF, and XML formats compliant with LIMS integration standards. The software records timestamped event logs—including run start/stop, parameter changes, door openings, error codes, and temperature deviations—with immutable hashing for integrity verification. Exported reports include RCF/time profiles, thermal history plots, and rotor usage counters synchronized with manufacturer-maintained calibration certificates. Data retention policies align with ISO/IEC 17025:2017 Clause 7.5.2 for record preservation duration and accessibility.

Applications

• Life sciences: Isolation of exosomes, mitochondria, and ribosomal subunits; density gradient ultracentrifugation prep (e.g., sucrose/Percoll)
• Pharmaceutical development: Clarification of monoclonal antibody harvests, removal of host cell proteins, and formulation stability testing
• Environmental analysis: Sedimentation of suspended solids from wastewater, soil leachates, and airborne particulate filters
• Clinical diagnostics: Rapid plasma separation for coagulation assays, serum harvesting for immunoassays, and PBMC isolation
• Food & agriculture: Fat extraction from dairy emulsions, starch granule purification, and mycotoxin cleanup prior to LC-MS/MS
• Industrial chemistry: Catalyst recovery, polymer fractionation, and nanoparticle size classification by differential settling velocity

FAQ

What is the maximum allowable imbalance tolerance before automatic shutdown?
The system triggers immediate stoppage when radial force asymmetry exceeds 25 g·cm, corresponding to ≤1.5 g mass difference between opposing buckets at 16,000 rpm.
Can the DG1616RE operate continuously for >24 hours?
Yes—continuous runtime mode is supported with active thermal regulation and motor duty-cycle monitoring to prevent overheating.
Is rotor calibration required annually?
DLAB recommends annual verification using NIST-traceable tachometer and thermometer; factory calibration certificates include uncertainty budgets per ISO/IEC 17025.
Does the centrifuge support external communication protocols?
RS-232 and Ethernet (TCP/IP) ports enable SCADA integration and remote command execution via ASCII protocol defined in DLAB Communication Protocol v3.2.
How is condensate managed during low-temperature operation?
Condensate is routed to an internal evaporator chamber heated to 45 °C during idle periods, eliminating manual drainage requirements.