Drick DRK-Z810P Automated Micro Polarimeter with Switchable Modes for Specific Rotation, Concentration & Saccharimetric Scale
| Brand | Drick |
|---|---|
| Origin | Shandong, China |
| Manufacturer Type | OEM/ODM Manufacturer |
| Country of Origin | China |
| Model | DRK-Z810P |
| Product Category | Automatic Polarimeter |
| Temperature Control | Integrated Peltier-based Thermostatic Cell Holder (±0.1 °C stability) |
| Digital Display | High-Resolution LCD with Real-Time Parameter Readout |
| Light Source | 589.3 nm LED (Sodium D-Line Equivalent) |
| Measurement Range | Optical Rotation ±90° |
| Accuracy | ±0.004° (at 20 °C, standard quartz control plate verification) |
Overview
The Drick DRK-Z810P Automated Micro Polarimeter is a precision optical instrument engineered for high-reproducibility measurement of optical rotation in optically active substances—principally carbohydrates, amino acids, pharmaceutical intermediates, and chiral compounds. Based on the fundamental principle of polarimetry—detection of angular deviation of plane-polarized light after transmission through a chiral medium—the DRK-Z810P employs a stabilized 589.3 nm LED light source calibrated to sodium D-line spectral equivalence, ensuring compliance with pharmacopeial requirements (USP , EP 2.2.7, ChP IV). Its micro-volume cell design (minimum sample volume: 0.5 mL) supports efficient use of high-value or limited-availability samples, while integrated Peltier temperature regulation maintains the measurement cell at user-selectable setpoints from 10 °C to 40 °C (±0.1 °C), critical for thermally sensitive assays and standardized method execution.
Key Features
- Triple-mode operational interface: seamless switching between specific rotation ([α]), concentration (g/100 mL), and saccharimetric scale (°Z) without recalibration or manual formula input
- Automated zero-point compensation and real-time drift correction via dual-detector optical architecture
- High-accuracy angular detection system with resolution of 0.001° and certified accuracy of ±0.004° under ISO 13682:2017 verification conditions
- Thermostatically controlled sample cell holder with programmable ramping and hold functions, compliant with GLP temperature documentation requirements
- Modular 100 mm and 200 mm pathlength cell compatibility (standard quartz cells, optional stainless-steel jacketed variants for aggressive solvents)
- RS-232 and USB-B interfaces supporting bidirectional communication with LIMS and validated laboratory software platforms
Sample Compatibility & Compliance
The DRK-Z810P accommodates aqueous solutions, ethanol/water mixtures, glycerol-based matrices, and low-viscosity organic solvents (e.g., chloroform, ethyl acetate) within defined refractive index limits (1.33–1.52). It supports routine analysis of sucrose, glucose, fructose, lactose, and invert sugar per ICUMSA Method GS2/3-12 and AOAC Official Method 952.04. Instrument validation follows IQ/OQ protocols aligned with ASTM E2919-20 and ISO/IEC 17025:2017 calibration traceability to NIM (National Institute of Metrology, China) and NIST-traceable quartz control plates. Full audit trail capability—including operator ID, timestamp, temperature log, and raw detector voltage data—is retained for FDA 21 CFR Part 11-compliant environments when paired with validated Drick PolarSoft v3.2.
Software & Data Management
Drick PolarSoft v3.2 (Windows 10/11 compatible) provides method-driven workflow management, including customizable report templates (PDF/CSV/XLSX export), multi-user permission levels, electronic signature support, and automatic generation of USP/EP-compliant certificates of analysis. Raw angular data is stored with metadata tags (cell ID, temperature, wavelength, date/time, operator), enabling retrospective reprocessing and statistical process control (SPC) charting. The software includes built-in uncertainty calculation per GUM (JCGM 100:2008) and supports integration with enterprise-level LIMS via HL7 or ASTM E1384 interfaces.
Applications
- Pharmaceutical QC: identity testing and assay of chiral APIs (e.g., levodopa, ibuprofen, chloramphenicol) per USP monographs
- Food & Beverage: Brix-equivalent sugar content verification in syrups, juices, honey, and confectionery raw materials
- Biotechnology: monitoring enzymatic hydrolysis kinetics of polysaccharides (e.g., starch → dextrose conversion)
- Academic Research: determination of enantiomeric excess (ee%) in asymmetric synthesis reactions
- Chemical Manufacturing: batch release testing of optically pure intermediates in fine chemical production
- Regulatory Compliance: submission-ready data packages for CFDA, PMDA, Health Canada, and EMA dossier filings
FAQ
Does the DRK-Z810P meet pharmacopeial requirements for polarimetric assay?
Yes—it conforms to USP , European Pharmacopoeia 2.2.7, and Chinese Pharmacopoeia IV general chapter for polarimeters, including wavelength tolerance, temperature control, and accuracy specifications.
Can the instrument be validated under GMP/GLP conditions?
Yes—full IQ/OQ documentation packages are available, and the system supports 21 CFR Part 11-compliant electronic records when used with validated PolarSoft v3.2 and controlled access protocols.
What is the minimum required sample volume?
0.5 mL for standard 100 mm pathlength quartz cells; optional micro-cells (25 mm) reduce requirement to 0.15 mL.
Is temperature calibration traceable to national standards?
Yes—integrated Pt100 sensor is factory-calibrated against NIM-certified reference thermometers, with certificate included.
How is measurement repeatability verified?
Via daily verification using NIST-traceable quartz control plates (±0.01° nominal value), with automated pass/fail reporting in PolarSoft.
